A risk factor is anything that increases a person’s chance of developing a disease. Although risk factors often influence the development of a disease, most do not directly cause the disease itself. Some people with several risk factors may never develop amyloidosis, while others with no known risk factors do.
Although the root cause of amyloidosis is unknown, there are several risk factors for cardiac amyloidosis, including: Age, Gender, Family History/Race

TTR mutations more commonly affects black populations in the US. 3.4% of African Americans have Val122Ile mutation which usually results in isolated cardiomyopathy. In Europe and Asia, mutations of TTR may lead to both cardiac involvement and familial amyloid polyneuropathy most often caused by Val30Met mutation.

What are the risk factors?


AL

PRECURSOR PROTEIN
Light Chains

Risk factors included heart and hepatic involvement, hypotension and impairment of renal function. High serum creatinine level and hypotension at diagnosis are associated with poor renal outcome

ATTRwt

PRECURSOR PROTEIN
Wild-type

Not known to be heritable


ATTRm

PRECURSOR PROTEIN
Mutant Transthyretin

V122I has African-American / Caribbean origin. In V122I, the usual age of onset is 60-65 years.

AA (Secondary)

PRECURSOR PROTEIN
Serum Amyloid A

May occur with severe inflammatory disease

Risk Factors

Symptoms