The Goncharova Lab
Welcome to the Goncharova Lab, part of UC Davis Health's Department of Internal Medicine and Division of Pulmonary, Critical Care and Sleep Medicine. Our research interests have focused on the molecular and cellular mechanisms of pulmonary hypertension. Our goals are:
- to dissect new signaling hubs driving hyper-proliferation of resident pulmonary vascular cells, pulmonary vascular remodeling and PAH;
- to identify and pre-clinically validate novel molecular target pathways for therapeutic intervention;
- to develop in vitro human-based models for molecular and pre-clinical studies.
- The role of mTOR signaling network and growth suppressor TSC2 in pulmonary vascular cell reprograming, PA remodeling and right ventricular dysfunction in pulmonary arterial hypertension.
- The role of HIPPO signaling cassette in pulmonary vascular cell hyper-proliferation, development and progression of pulmonary hypertension.
- GATA6 transcriptional factor as a regulator of pulmonary vascular cell-cell communications, BMP signaling and inflammation in pulmonary hypertension.
- Lipid metabolism as a regulator of pulmonary vascular remodeling and pulmonary hypertension.
Director, Pulmonary Vascular Disease Program, UC Davis Lung Center
Assistant Adjunct Professor
Staff Research Associate III
Staff Research Associate II
Click here to see a complete list of published work.
Shen Y, Goncharov DA, Pena A, Baust J, Chavez Barragan A, Ray A, Rode A, Bachman TN, Chang B, Jiang L, Dieffenbach P, Fredenburgh LE, Rojas M, DeLisser H, Mora AL, Kudryashova TV, Goncharova EA. Cross-talk between TSC2 and the extracellular matrix controls pulmonary vascular proliferation and pulmonary hypertension. Science Signaling, 2022 Dec 6;15(763):eabn2743. doi: 10.1126/scisignal.abn2743. Epub 2022 Dec 6. PubMed PMID: 36473049. (https://www.science.org/stoken/author-tokens/ST-891/full)
- Jiang L, Goncharov DA, Shen Y, Lin D, Chang B, Pena A, DeLisser H, Goncharova EA*, Kudryashova TV*. Akt-Dependent Glycolysis-Driven Lipogenesis Supports Proliferation and Survival of Human Pulmonary Arterial Smooth Muscle Cells in Pulmonary Hypertension. Frontiers in Medicine, 2022, 9: 886868.
- Kudryashova TV#, Dabral S#, Nayakanti S, Ray A, Goncharov DA, Avolio T, Shen Y, Rode A, Pena A, Jiang L, Lin D, Baust J, Bachman TN, Graumann J, Ruppert C, Guenther A, Schmoranzer M, Grobs Y, Eve Lemay S, Tremblay E, Breuils-Bonnet S, Boucherat O, Mora AL, DeLisser H, Zhao J, Zhao Y, Bonnet S, Seeger W, Pullamsetti SS*, Goncharova EA*. Noncanonical HIPPO/MST Signaling via BUB3 and FOXO Drives Pulmonary Vascular Cell Growth and Survival. Circulation Research, 2022, 130(5):760-778.
- Satoh T, Wang L, Levine A, Hahn S, Baust J, Wyman S, Salamacha N, Wu Y, Espinosa-Diez C, Reynolds M, Shiva S, St Hilaire C, Gomez D, Goncharov DA, Goncharova EA, Straub A, Lai YC, McTiernan CF, Gladwin MT. Metabolic syndrome mediates ROS-miR-193b-NFYA-dependent down regulation of sGC activity and contributes to exercise-induced pulmonary hypertension in HFpEF. Circulation, 2021, 144(8):615-637.
- Culley MK, Zhao J, Tai YY, Tang Y, Perk D, Negi V, Yu Q, Woodcock J, Handen A, Speyer G, Kim S, Lai YC, Satoh T, Watson A, Aaraj YA, Sembrat J, Rojas M, Goncharov D, Goncharova EA, Khan OF, Anderson DG, Dahlman JE, Gurkar A, Lafyatis R, Fayyaz A, Redfield M, Gladwin MT, Rabinovitch M, Gu M, Bertero T, Chan SY. Frataxin deficiency promotes endothelial senescence in pulmonary hypertension. Journal of Clinical Investigation, 131(11):e136459, 2021.
- Sharifi-Sanjani M, Berman M, Goncharov D, Alhamaydeh M, Avolio TG, Baust J, Chang B, Kobir A, Ross M, St. Croix C, McTiernan C, Moravec CS, Goncharova EA*, Al Ghouleh I* (*equal senior author contribution): Yes-associated Protein (Yap) is Up-Regulated in Heart Failure and Promotes Cardiac Fibroblast Proliferation. International Journal of Molecular Sciences, 22(11):6164, 2021.
- Daneva Z, Marziano C, Ottolini M, Chen YL, Hong K, Cope EL, Baker TM, Zhang A, Ta H, Mihalek AD, Minshall RD, Kasetti RB, Shen Y, Zode GS, Goncharova EA, Laubach VE, Sonkusare SK. Caveolar peroxynitrite formation impairs endothelial TRPV4 channels and elevates pulmonary arterial pressure in pulmonary hypertension. Proceedings of the National Academy of Science, 118(17):e2023130118, 2021.
- Shen Y, Goncharov DA, Avolio T, Ray A, Okorie E, Mora AL, Vanderpool R, Kudryashova TV, Goncharova EA. Differential effects of integrin-linked kinase inhibitor Cpd22 on severe pulmonary hypertension in male and female rats. Pulmonary Circulation, 10(1): 2045894019898593, 2020.
- Farkas D, Thompson AAR, Bhagwani AR, Hultman S, Ji H, Kotha N, Farr G, Arnold ND, Braithwaite A, Casbolt H, Sabroe CGEI, Monaco C, Cool CD, Goncharova EA, Lawrie A, Farkas L. Toll-like receptor 3 is a therapeutic target for Pulmonary Hypertension. American Journal of Respiratory and Critical Care Medicine, 199(2):199-210, 2019.
- Kudryashova TV#, Shen Y#, Pena A, Cronin E, Okorie E, Goncharov DA, Goncharova EA. Inhibitory antibodies against Activin A and TGF-β reduce self-supported, but not soluble factors-induced growth of human pulmonary arterial vascular smooth muscle cells in pulmonary arterial hypertension. International Journal of Molecular Sciences, 19(10), 2957, 2018.
- Goncharov DA, Goncharova EA, Tofovic SP, Hu J, Baust JJ, Pena AZ, Ray A, Rode A, Vanderpool RR, Mora AL, Gladwin MT, Lai YC. Metformin Therapy for Pulmonary Hypertension Associated with Heart Failure with Preserved Ejection Fraction versus Pulmonary Arterial Hypertension. American Journal of Respiratory and Critical Care Medicine, 198(5):681-684, 2018.
- Pena A#, Kobir A#, Goncharov D, Goda A, Vanderpool R, Baust J, Chang B, Mora AL, Gorcsan J III, Goncharova EA. Pharmacological inhibition of mTOR kinase reverses right ventricle remodeling and improves right ventricle structure and function in rats. American Journal of Respiratory Cell and Molecular Biology, 57(5):615-625, 2017.
- Kudryashova TV#, Goncharov DA#, Pena A, Kelly N, Vanderpool R, Baust J, Kobir A, Shufesky W, Mora AL, Morelli AE, Zhao J, Ihida-Stansbury K, Chang B, DeLisser H, Tuder RM, Kawut SM, Silljé HHW, Shapiro S, Zhao Y, Goncharova EA. HIPPO-integrin linked kinase crosstalk controls self-sustaining proliferation and survival in pulmonary hypertension. American Journal of Respiratory and Critical Care Medicine, 194(7):866-877, 2016.
- Goncharov DA, Kudryashova TV, Ziai H, Ihida-Stansbury K, DeLisser H, Krymskaya VP, Tuder RM, Kawut SM, Goncharova EA. mTORC2 coordinates pulmonary artery smooth muscle cell metabolism, proliferation and survival in pulmonary arterial hypertension. Circulation, 129(8):864-74, 2014.
Reviews & Editorials
- Kudryashova TV, Goncharova EA. MonOrail to Cure? Targeting Orai1 to Reverse Pulmonary Arterial Hypertension. Circulation Research, 2022 Oct 14;131(9):728-730. doi: 10.1161/CIRCRESAHA.122.321924. Epub 2022 Oct 13. PubMed PMID: 36252052; PubMed Central PMCID: PMC9586488.
- Goncharova EA, Farkas L. Stem Cell-derived Nanovesicles for the Treatment of Pulmonary Hypertension: Are We There Yet?. American Journal of Respiratory Cell and Molecular Biology, 2022 Jul;67(1):3-5. doi: 10.1165/rcmb.2022-0078ED. PubMed PMID: 35522729; PubMed Central PMCID: PMC9273228.
- Goncharova EA, Chan SY, Ventetuolo SE, Weissmann N, Schermuly RT, Mullin CJ, Gladwin MT. Update in pulmonary vascular diseases and right ventricular dysfunction in 2019. American Journal of Respiratory and Critical Care Medicine, 202(1):22-28, 2020.
- Goncharova EA, Simon MA, Yuan JXJ. mTORC1 in Pulmonary Arterial Hypertension: at the crossroads between vasoconstriction and vascular remodeling? American Journal of Respiratory and Critical Care Medicine, 201(10):1177-1179, 2020.
- Spiekerkoetter E, Goncharova EA, Guignabert C, Stenmark K, Kwapiszewska G, Rabinovitch M, Voelkel N, Bogaard HJ, Graham B, Pullamsetti SS, Kuebler WM. Hot topics in Pulmonary Arterial Hypertension Disease Mechanisms: Cancer-like pathobiology, the role of the adventitia, systemic involvement, and right ventricular failure. Pulmonary Hypertension, 9(4):2045894019889775, 2019.
- Lai YC, Provencher S., Goncharova EA. TAKling GDF-15 and Skeletal Muscle Atrophy in Pulmonary Hypertension: Are We There Yet? Thorax, 74(2):103-105, 2019.
- Shen Y and Goncharova EA. TWISTed HIF: Re-visiting Smooth Muscle HIF-1α Signaling in Pulmonary Hypertension. American Journal of Physiology:Lung Cellular and Molecular Physiology, 315(3):L387-L389, 2018.
- Pullamsetti SS, Savai R, Seeger W, Goncharova EA. Translational Advances in the field of Pulmonary Hypertension. From cancer biology to new PAH therapeutics: Targeting cell growth and proliferation signaling hubs. American Journal of Respiratory and Critical Care Medicine, 195(4):425-437, 2017.
- Goncharova EA, Gladwin MT, Kawut SM. Update in Pulmonary Vascular Diseases 2014. American Journal of Respiratory and Critical Care Medicine, 192(5): 544-550, 2015.
- Goncharova EA. mTOR and vascular remodeling in lung diseases: current challenges and therapeutic prospects. The FASEB Journal, 27(5): 1796-1807, 2013.
- December 2022: Our paper "Cross-talk between TSC2 and the extracellular matrix controls pulmonary vascular proliferation and pulmonary hypertension" was published in the Science Signaling and we are on the cover of the magazine too! Congratulations to Steve Shen, Dmitry Goncharov, and the team! Learn more at https://www.science.org/stoken/author-tokens/ST-891/full
June 2022: Please read our recent paper in the Frontiers in Medicine titled Akt-Dependent Glycolysis-Driven Lipogenesis Supports Proliferation and Survival of Human Pulmonary Arterial Smooth Muscle Cells in Pulmonary Hypertension. Learn more at https://www.frontiersin.org/articles/10.3389/fmed.2022.886868/full
- May 2022: Congratulations to Dr Jiang (first author) and Dr Kudryashova (senior author) on the Abstract Scholarship Award from the Pulmonary Circulation Assembly of the American Thoracic Society 2022 International Conference in San Franscisco. Well done and well deserved!
- March 2022: Congratulations to Dr. Jiang on his Rapid Talk Presentation Award from the 7th Annual Postdoctoral Research Symposium of UC Davis.
- March 2022: Congratulations to Dr. Shen on the President's Award from the California Thoracic Society 2022 Annual Educational Conference!
- March 2022: Congratulations to Dr. Shen on the UC Davis PSA Travel Award!
February 2022: Please read our recent paper in the Circulation Research on the novel role of MST1/2 in pulmonary hypertension! The study led by Drs. Kudryashova, Dabral & colleagues report that MST1 act as pro-proliferative and pro-survival molecules via BUB3 and FOXO in PAH pulmonary vasculature. Learn more at http://ow.ly/S5Co30sc7hw
- November 2021: Dr. Goncharova was recognized as an Expertscape Expert in in Pulmonary Arterial Hypertenion.
- August 2021: Congratulations to Dr. Shen on the American Heart Association Postdoctoral Award and the Jane Morse Award from the American Thoracic Society Pulmonary Circulation Assembly! Well done, Steve!