Welcome to the Goncharova Lab, part of UC Davis Health's Department of Internal Medicine and Division of Pulmonary, Critical Care and Sleep Medicine. Our research interests have focused on the molecular and cellular mechanisms of pulmonary hypertension. Our goals are:

- to dissect new signaling hubs driving hyper-proliferation of resident pulmonary vascular cells, pulmonary vascular remodeling and PAH;

- to identify and pre-clinically validate novel molecular target pathways for therapeutic intervention;

- to develop in vitro human-based models for molecular and pre-clinical studies.

Goncharova Lab Research Example

  1. The role of mTOR signaling network and growth suppressor TSC2 in pulmonary vascular cell reprograming, PA remodeling and right ventricular dysfunction in pulmonary arterial hypertension.
  2. The role of HIPPO signaling cassette in pulmonary vascular cell hyper-proliferation, development and progression of pulmonary hypertension.
  3. GATA6 transcriptional factor as a regulator of pulmonary vascular cell-cell communications, BMP signaling and inflammation in pulmonary hypertension.
  4. Lipid metabolism as a regulator of pulmonary vascular remodeling and pulmonary hypertension.

Elena Goncharova head shot

Elena Goncharova, Ph.D.

Professor

Director, Pulmonary Vascular Disease Program,  UC Davis Lung Center

Tatiana Kudryash headshot

Tatiana Kudryashova, Ph.D.

Assistant Adjunct Professor

Dmitry Goncharov, M.S.

Staff Research Associate III

Lab Manager

Yuanjun (Steven) Shen, Ph.D.

Postdoctoral Researcher

Lifeng Jiang, Ph.D.

Postdoctoral Researcher

Iryna Zhyvylo

Iryna Zhyvyo, M.D., Ph.D.

Postdoctoral Researcher

Leyla Teos, Ph.D.

Staff Research Associate II

Derek Lin, B.S.

Lab Assistant

Aisha Saiyed

Undergraduate Researcher

 

Click here to see a complete list of published work.

Selected Publications:

  • Culley MK, Zhao J, Tai YY, Tang Y, Perk D, Negi V, Yu Q, Woodcock J, Handen A, Speyer G, Kim S, Lai YC, Satoh T, Watson A, Aaraj YA, Sembrat J, Rojas M, Goncharov D, Goncharova EA, Khan OF, Anderson DG, Dahlman JE, Gurkar A, Lafyatis R, Fayyaz A, Redfield M, Gladwin MT, Rabinovitch M, Gu M, Bertero T, Chan SY. Frataxin deficiency promotes endothelial senescence in pulmonary hypertension. Journal of Clinical Investigation, 131(11):e136459, 2021.

Reviews & Editorials

 

  • December 2022: Our paper "Cross-talk between TSC2 and the extracellular matrix controls pulmonary vascular proliferation and pulmonary hypertension" was published in the Science Signaling and we are on the cover of the magazine too! Congratulations to Steve Shen, Dmitry Goncharov, and the team! Learn more at https://www.science.org/stoken/author-tokens/ST-891/full

       

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  • May 2022: Congratulations to Dr Jiang (first author) and Dr Kudryashova (senior author) on the Abstract Scholarship Award from the Pulmonary Circulation Assembly of the American Thoracic Society 2022 International Conference in San Franscisco. Well done and well deserved!

      Tatiana Kudryashova, Assistant Adjunct Professor and Lifeng Jiang, Postdoctoral Scholar

  • March 2022: Congratulations to Dr. Jiang on his Rapid Talk Presentation Award from the 7th Annual Postdoctoral Research Symposium of UC Davis.

  • March 2022: Congratulations to Dr. Shen on the President's Award from the California Thoracic Society 2022 Annual Educational Conference!

        Yuanjun Shen, Postdoctoral Scholar

  • March 2022: Congratulations to Dr. Shen on the UC Davis PSA Travel Award! 

  • February 2022: Please read our recent paper in the Circulation Research on the novel role of MST1/2 in pulmonary hypertension! The study led by Drs. Kudryashova, Dabral & colleagues report that MST1 act as pro-proliferative and pro-survival molecules via BUB3 and FOXO in PAH pulmonary vasculature. Learn more at http://ow.ly/S5Co30sc7hw

  • November 2021: Dr. Goncharova was recognized as an Expertscape Expert in in Pulmonary Arterial Hypertenion.

  • August 2021: Congratulations to Dr. Shen on the American Heart Association Postdoctoral Award and the Jane Morse Award from the American Thoracic Society Pulmonary Circulation Assembly! Well done, Steve!