Welcome to the Goncharova Lab, part of UC Davis Health's Department of Internal Medicine and Division of Pulmonary, Critical Care and Sleep Medicine. Our research interests have focused on the molecular and cellular mechanisms of pulmonary hypertension. Our goals are:

- to dissect new signaling hubs driving hyper-proliferation of resident pulmonary vascular cells, pulmonary vascular remodeling and PAH;

- to identify and pre-clinically validate novel molecular target pathways for therapeutic intervention;

- to develop in vitro human-based models for molecular and pre-clinical studies.

Lab members group

Goncharova Lab Research Example

  1. The role of mTOR signaling network and growth suppressor TSC2 in pulmonary vascular cell reprograming, PA remodeling and right ventricular dysfunction in pulmonary arterial hypertension.
  2. The role of HIPPO signaling cassette in pulmonary vascular cell hyper-proliferation, development and progression of pulmonary hypertension.
  3. GATA6 transcriptional factor as a regulator of pulmonary vascular cell-cell communications, BMP signaling and inflammation in pulmonary hypertension.
  4. Lipid metabolism as a regulator of pulmonary vascular remodeling and pulmonary hypertension.

Elena Goncharova head shot

Elena Goncharova, Ph.D.

Professor

Director, Pulmonary Vascular Disease Program,  UC Davis Lung Center

Tatiana Kudryash headshot

Tatiana Kudryashova, Ph.D.

Assistant Adjunct Professor

Dmitry Goncharov headshot

Dmitry Goncharov, M.S.

Staff Research Associate III

Lab Manager

Lifeng Jiang headshot

Lifeng Jiang, Ph.D.

Assistant Project Scientist

Iryna Zhyvylo headshot

Iryna Zhyvyo, M.D., Ph.D.

Postdoctoral Researcher

Derek Lin headshot

Derek Lin, B.S.

Lab Assistant

Aisha Saiyed headshot

Aisha Saiyed

Undergraduate Researcher

sanjana

Sanjana Neeli

Undergraduate Researcher

Alumni

Yuanjun (Steven) Shen, Ph.D.

Postdoctoral Researcher

Leyla Teos, Ph.D.

Staff Research Associate II

Click here to see a complete list of published work.

Selected Publications:

 

 

 

 

 

 

 

  • Culley MK, Zhao J, Tai YY, Tang Y, Perk D, Negi V, Yu Q, Woodcock J, Handen A, Speyer G, Kim S, Lai YC, Satoh T, Watson A, Aaraj YA, Sembrat J, Rojas M, Goncharov D, Goncharova EA, Khan OF, Anderson DG, Dahlman JE, Gurkar A, Lafyatis R, Fayyaz A, Redfield M, Gladwin MT, Rabinovitch M, Gu M, Bertero T, Chan SY. "Frataxin deficiency promotes endothelial senescence in pulmonary hypertension". Journal of Clinical Investigation, 131(11):e136459, 2021.

 

 

 

 

 

 

 

 

 

 

Reviews and Editorials

 

 

 

 

 

 

 

 

 

 

 

  • November 2023,  Big congratulations to Dr. Jiang on receiving the Cardiopulmonary, Critical Care, Perioperative, and Resuscitation (3CPR) Junior Investigator Travel Grants for the American Heart Association 2023 Scientific Sessions in Philadelphia. The abstract submitted by Dr. Jiang was ranked among the top 3 scoring PAH Biology Abstracts for 3CPR and was selected as one of six participants at the 2023 "Swimming with the Sharks" Early Career event. Well done, Lifeng!

        aha2023

  • November 2023, Congratulations to Dr Goncharova being named associate editor for the American Journal of Respiratory and Critical Care Medicine! Meet the New AJRCMB Editors: https://www.atsjournals.org/page/ajrcmb/meet_the_editors

  • May 2023: Big congratulations to Dr. Jiang on the Abstract Scholarship Award from the Pulmonary Circulation Assembly of the American Thoracic Society 2023 International Conference in Washington DC. This is a second Abstract Scholarship Award received by Dr. Jiang from the ATS PC Assembly! Well done, Lifeng!

        ats2023dc

  • April 2023: Our paper "GATA6 coordinates cross-talk between BMP10 and oxidative stress axis in pulmonary arterial hypertension" was published in the Scientific Reports! Congratulations to the first author Dr. Tatiana Kudryashova and team! Learn more about this study here: https://www.nature.com/articles/s41598-023-33779-8 

     gata6

  • April 2023: Congratulations to Dr. Yuanjun (Steven) Shen on the receiving NIH/NHLBI K99/R00 award to study the role of VPS34 in pulmonary arterial hypertension!

  • February 2023: Congratulations to Dr. Tatiana Kudryashova on the receiving NIH/NHLBI R01 award to study the role of HIPK2 signaling in pulmonary arterial hypertension!

  • December 2022: Our paper "Cross-talk between TSC2 and the extracellular matrix controls pulmonary vascular proliferation and pulmonary hypertension" was published in the Science Signaling and we are on the cover of the magazine too! Congratulations to Steve Shen, Dmitry Goncharov, and the team! Learn more at https://www.science.org/stoken/author-tokens/ST-891/full

        Science signaling magazine cover page

 

     signaling scheme

 

  • May 2022: Congratulations to Dr Jiang (first author) and Dr Kudryashova (senior author) on the Abstract Scholarship Award from the Pulmonary Circulation Assembly of the American Thoracic Society 2022 International Conference in San Franscisco. Well done and well deserved!

      ATS abstract award for Lifeng Jiang

 

  • March 2022: Congratulations to Dr. Jiang on his Rapid Talk Presentation Award from the 7th Annual Postdoctoral Research Symposium of UC Davis.

 

  • March 2022: Congratulations to Dr. Shen on the President's Award from the California Thoracic Society 2022 Annual Educational Conference!

        Yuanjun Shen poster presentation

 

  • March 2022: Congratulations to Dr. Shen on the UC Davis PSA Travel Award! 

 

  • February 2022: Please read our recent paper in the Circulation Research on the novel role of MST1/2 in pulmonary hypertension! The study led by Drs. Kudryashova, Dabral and colleagues report that MST1 act as pro-proliferative and pro-survival molecules via BUB3 and FOXO in PAH pulmonary vasculature. Learn more at http://ow.ly/S5Co30sc7hw

Circulation Research paper

 

  • November 2021: Dr. Goncharova was recognized as an Expertscape Expert in in Pulmonary Arterial Hypertenion.

 

  • August 2021: Congratulations to Dr. Shen on the American Heart Association Postdoctoral Award and the Jane Morse Award from the American Thoracic Society Pulmonary Circulation Assembly! Well done, Steve!