Ian McHardy, Ph.D.
3140 Tupper Hall
Dr. McHardy is Assistant Professor of Medicine at the University of California, Davis, School of Medicine in the Department of Medical Microbiology and Immunology. With expertise in basic and translational research involving multi-omic data integration, bioinformatic development, and clinical microbiology, his ongoing research program involves I) Development and optimization of new clinical microbiology diagnostics; II) Investigation of mechanisms of microbial virulence and host-microbe interactions in human diseases; and III) Study of antimicrobials and antimicrobial resistance.
Dr. McHardy is co-director of the UC Davis Coccidioidomycosis Serology Laboratory, which serves as the gold standard reference laboratory for serologic diagnosis of Valley Fever and receives both human and veterinary specimens from across the world. The serology laboratory plays key public health roles in detecting and reporting of cases of Coccidioidomycosis.
Dr. McHardy is also co-director of the UC Davis Center for Valley Fever, a consortium of 10 faculty whose mission is to improve patient care, diagnosis, and treatment of patients. Key activities of the Center for Valley Fever include educational outreach to improve public awareness and influence public policy.
Shaun Yang, Ian H. McHardy, Peera Hemarajata, Max Wu, Omai B. Garner. 2016. Microbial Recovery from Clot Activating Vacutainers®. Diagnostic Microbiology and Infectious Disease. 85: 4.
Tong M, Jacobs JP, McHardy IH, Braun J. 2014 Sampling of Intestinal Microbiota and Targeted Amplification of Bacterial 16S rRNA Genes for Microbial Ecologic Analysis. Curr Protoc Immunol. 107:7
Deak E, Charlton CL, Bobenchik AM, Miller SA, Pollett S, McHardy IH, Wu M, Garner OB. 2014. Comparison of the Vitek MS and Bruker Microflex LT MALDI-TOF MS Platforms for Routine Identification of Commonly Isolated Bacteria and Yeast in the Clinical Microbiology Laboratory. Diagnostic Microbiology and Infectious Disease. ISSN 0732-8893.
Tong M, McHardy I, Ruegger P, Goudarzi M, Kashyap PC, Haritunians T, Li X, Graeber TG, Schwager E, Huttenhower C, Fornace AJ, Sonnenburg JL, McGovern DPB, Borneman J, Braun J. 2014. Reprograming of gut microbiome energy metabolism by the FUT2 Crohn's disease risk polymorphism. ISME J.
Kaplan A, Kaplan CW, He X, McHardy I, Shi W, et al. (2014) Characterization of aid1, a Novel Gene Involved in Fusobacterium nucleatum Interspecies Interactions. Microbial Ecology: 1-9.
Sarkar J*, McHardy IH*, Simanian EJ, Shi W, Lux R (2014) Transcriptional Responses of Treponema denticola to Other Oral Bacterial Species. PloS one 9: e88361.
McHardy IH, Wu M, Shimizu-Cohen R, Couturier MR, Humphries RM (2014) Detection of Intestinal Protozoa in the Clinical Laboratory. Journal of Clinical Microbiology 52: 712-720.
McHardy IH, Li X, Tong M, Ruegger P, Jacobs J, et al. (2013) HIV Infection is associated with compositional and functional shifts in the rectal mucosal microbiota. Microbiome 1: 26.
McHardy IH, Goudarzi M, Tong M, Ruegger PM, Schwager E, et al. (2013) Integrative analysis of the microbiome and metabolome of the human intestinal mucosal surface reveals exquisite inter-relationships. Microbiome 1: 17.
Hu W, Li L, Sharma S, Wang J, McHardy I, et al. (2012) DNA builds and strengthens the extracellular matrix in Myxococcus xanthus biofilms by interacting with exopolysaccharides. PloS one 7: e51905.
Hu W, Wang J, McHardy I, Lux R, Yang Z, et al. (2012) Effects of exopolysaccharide production on liquid vegetative growth, stress survival, and stationary phase recovery in Myxococcus xanthus. The Journal of Microbiology 50: 241-248.
McHardy I, Keegan C, Sim J-H, Shi W, Lux R (2010) Transcriptional profiles of Treponema denticola in response to environmental conditions. PloS one 5: e13655.
Jia Q, Freeman ML, Yager EJ, McHardy I, Tong L, et al. (2010) Induction of protective immunity against murine gammaherpesvirus 68 infection in the absence of viral latency. Journal of virology 84: 2453-2465.
Eckert R, Mchardy I, Yarbrough DK, He J, Qi F, et al. (2007) Stability and Activity in Sputum of G10KHc, a Potent Anti‐Pseudomonas Antimicrobial Peptide. Chemical biology & drug design 70: 456-460.
Eckert R, Brady KM, Greenberg EP, Qi F, Yarbrough DK, He J, McHardy I, Anderson MH, Shi W. (2006) Enhancement of antimicrobial activity against Pseudomonas aeruginosa by coadministration of G10KHc and tobramycin. Antimicrobial agents and chemotherapy 50: 3833-3838.
Aguilar HC, Matreyek KA, Filone CM, Hashimi ST, Levroney EL, Negrete OA, Bertolotti-Ciarlet A, Choi DY, McHardy I, Fulcher JA, Lee B (2006) N-glycans on Nipah virus fusion protein protect against neutralization but reduce membrane fusion and viral entry. Journal of virology 80: 4878-4889.
Jia Q, Chernishof V, Bortz E, Mchardy I, Wu T-T, et al. (2005) Murine gammaherpesvirus 68 open reading frame 45 plays an essential role during the immediate-early phase of viral replication. Journal of virology 79: 5129-5141