Fragile X

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Updates in Research in Neurodevelopmental Disabilities

Updates in Research in Neurodevelopmental Disabilities

Updates in Research in Neurodevelopmental Disabilities

Presenters: Leonard Abbeduto, Ph.D., Randi J. Hagerman, M.D.,

Julie B. Schweitzer, Ph.D., and Christine Wu Nordahl, Ph.D.

Affiliation: UC Davis MIND Institute

Date: July 28, 2017

Length: 1:18:16

Summary: Keynote Address from 2017 Summer Institute. This panel of experts provided an update on some of the most current research in neurodevelopmental disabilities taking place at the UC Davis MIND Institute, including: using technology and parent partnerships to deliver language therapies into the homes of individuals affected by neurodevelopmental disorders, targeted treatments for neurodevelopmental disorders using fragile X syndrome as a model, developmental changes associated with ADHD and relevance to treatment and comorbid issues, as well as sex differences in the neurobiology of autism spectrum disorder.


Fragile X-associated Disorders and Targeted Treatments

Fragile X-associated Disorders and Targeted Treatments

Fragile X-associated Disorders and Targeted Treatments

Presenter: Randi J. Hagerman, M.D.

Affiliation: UC Davis MIND Institute

Date: May 1, 2016

Length: 40:20


MIND Institute faculty present their current research and its potential applications

MIND Institute faculty present their current research and its potential applications

MIND Institute faculty present their current research and its potential applications

Presenters: Randi Hagerman, M.D., Robin Hansen, M.D., Julie Schweitzer, Ph.D., and Tony Simon, Ph.D..

Affiliation: UC Davis MIND Institute

Date: November 17, 2011

Length: 1:19:53

Synopsis: Faculty will present research updates on autism, fragile X syndrome, Chromosome 22Q11.2 Deletion Syndrome, and Attention Deficit/Hyperactivity Disorder. Included in the discussion will be information about potential applications in preventing and treating these disorders.


Full and Premutations in Fragile X Syndrome: Translating New Science to Targeted Treatments in Autism and Neurodegenerative Disorders

Full and Premutations in Fragile X Syndrome: Translating New Science to Targeted Treatments in Autism and Neurodegenerative Disorders

Full and Premutations in Fragile X Syndrome: Translating New Science to Targeted Treatments in Autism and Neurodegenerative Disorders

Presenters: Randi Hagerman, M.D., Paul Hagerman, Ph.D., David Hessl, Ph.D. & Susan Rivera, Ph.D.

Affiliation: UC Davis MIND Institute

Date: November 18, 2010

Length: 1:25:24

Synopsis: The Fragile X Team discusses clinical involvement in patients with both the premutation and the full mutation including autism spectrum disorders, ADHD, anxiety, and premature ovarian failure. FXTAS (Fragile X Associated Tremor Ataxia Syndrome) and new targeted treatments for Fragile X Syndrome are also discussed.

A New Age of Treatment for Fragile X Syndrome

A New Age of Treatment for Fragile X Syndrome

A New Age of Treatment for Fragile X Syndrome

Presenter: Randi Hagerman, M.D.

Affiliation: UC Davis MIND Institute

Date: August 7, 2009

Length: 58:05

Summary: Neurobiological abnormalities in Fragile X Syndrome, review of targeted treatments available and the mechanisms by which they work, with preliminary data regarding minocycline, fenobam, and R-baclofen.


Fragile X: A Family Affair

Fragile X: A Family Affair

Fragile X: A Family Affair

Presenters: Paul Hagerman, M.D.,Ph.D. & Randi Hagerman, M.D.

Affiliation: UC Davis MIND Institute

Date: January 17, 2008

Length: 1:41:28

Synopsis: It's hard to imagine, but defects in a single gene can cause mental impairment in children, premature ovarian failure in women and dementia in older adults. That gene -- the fragile X gene -- is the research focus of two MIND Institute investigators who are leading the way in discovering the molecular foundations of and new treatments for the broad spectrum of fragile X-related disorders. Hear more about what their work has revealed about the causes and outcomes of fragile X syndrome, their plans for new treatment trials and the benefits of their discoveries for understanding neurodevelopmental and neurodegenerative disorders.


Three Disorders, One Explanation?

Three Disorders, One Explanation?

Three Disorders, One Explanation? The Case of Cognitive Impairments in Fragile X Syndrome, Turner and Chromosome 22q11.2 Deletion Syndrome

Presenter: Tony Simon, Ph.D.

Affiliation: UC Davis MIND Institute

Date: Oct 16, 2008

Length: 1:07:28

Synopsis: Chromosome 22q11.2 deletion, Turner, and fragile X syndromes are different genetic disorders producing weakness in visuospatial, visuomotor and numerical cognition. 7 to 14 year old children with these disorders were studied to see if a common mechanism might be at work. Dr. Simon will present results from experimental cognitive and brain imaging studies that explain how children with these disorders think about space, time and number and suggest designs for therapeutic interventions.


What We Learn About Autism from Studying Fragile X Syndrome

What We Learn About Autism from Studying Fragile X Syndrome

What We Learn About Autism from Studying Fragile X Syndrome

Presenters: David Hessl, Ph.D., Lisa Cordeiro

Affiliation: UC Davis MIND Institute

Date: Jan 22, 2009

Length: 54:22

Synopsis: Individuals with autism and fragile X syndrome share many symptoms and there may be common neurobiological abnormalities underlying these symptoms. Dr. Hessl will share recent findings from his laboratory and others focusing on this topic and discuss implications that the overlapping features may have for the treatment of both conditions.