Bronte Epilepsy Research Laboratories

These Laboratories focus on studying the neurobiological mechanisms underlying epilepsies and conditions related to seizure disorders. The rationale behind this research effort is that a better understanding of basic mechanisms of seizure disorders will lead to the development of better and more effective therapies, and cures. These Laboratories seek to establish collaborations with other UC Davis faculty whose interests and expertise significantly enhance the epilepsy-related research efforts. In addition, the Laboratories serve as a training ground for students and fellows interested in pursuing research and/or clinical careers in the neurobiology/neurology of seizures and related neurological disorders.

Principal Investigators

Philip A. Schwartzkroin, Ph.D.
H. Jurgen Wenzel, M.D., D.Sc.
Robert F. Berman, Ph.D.
Bruce G. Lyeth, Ph.D.

Funding Sources

National Institutes of Health
American Epilepsy Society
Epilepsy Foundation
Citizens United for Research in Epilepsy
UC Davis M.I.N.D Institute
UC Davis Health Systems Research Awards Program
UC Neurotrauma Initiative (Brain Injury Research Center)

Ongoing Research Projects

  • Exploration of structure – function relationships in animal models of cortical dysplasia and epilepsy
  • Development and characterization of a rat model of tuberous sclerosis
  • Development and characterization of a rodent model of post-traumatic epilepsy
  • Application of gene transfection methods to “repairing” lost neuronal function due to gene mutation in an animal model of genetic epilepsy
  • Development and characterization of an in vitro model of excitotoxicity
  • Investigations in an in vitro system to study the processes and consequences of aberrant neuronal migration and resulting cortical disorganization
  • Development of a rat model of autism to investigate potential bases for seizure susceptibility in autism