The UC Davis Alzheimer’s Disease Center announced three recipients of the 2018-19 research pilot grants. Each researcher will receive $32,000 funded by National Institute on Aging (NIA) Alzheimer’s Disease Center program to pursue pilot projects related to Alzheimer’s disease and other dementias with the goal of generating data to support future research applications.
This year’s recipients include:
· “Naturalistic Memory and Neurocognitive Aging”
Charan Ranganath, professor in the UC Davis Department of Psychology, and his team will use innovative combinations of novel memory measures and computational analysis of brain imaging data to identify subtle changes in memory that may predict Alzheimer’s disease risk.
· “Lipidomic Characterization of Brain Repair Pathways in Alzheimer’s Disease Brains”
Ameer Taha, assistant professor in the UC Davis Department of Food Science and Technology, and his team will test the hypothesis that repair lipid mediators are reduced in post-mortem Alzheimer’s disease brains because they are trapped by larger, more complex lipid structures within the brain. By demonstrating that Alzheimer’s disease pathology involves the abnormal trapping of repair lipid mediators, researchers can target hidden pathways as a way to stimulate brain repair.
· “Influence of Glycosylation on HDL Function in Alzheimer’s Disease”
Angela Zivkovic, assistant professor in the UC Davis Department of Nutrition, and her team will use newly developed glycomic and glycoproteomic methods to comprehensively characterize the glycans attached to proteins and lipids in the brain and in plasma lipoproteins. The ultimate goal of the project is to develop biomarkers for screening and the early detection of Alzheimer’s disease and targets for the prevention and treatment of inflammation of Alzheimer’s disease.
For 27 years, the NIA has provided funding to the Alzheimer’s Disease Center as an Alzheimer’s Disease Core Center. Since 2000, nearly $1 million has been invested in pilot awards from the UC Davis Alzheimer’s Disease Center grant.
The UC Davis Alzheimer's Disease Center is one of only 32 Alzheimer’s research centers designated by the National Institutes of Health's National Institute on Aging as a center of excellence. The center's goal is to translate research advances into improved diagnosis and treatment for patients while focusing on the long-term goal of finding a way to prevent or cure Alzheimer's disease.