Mary Jacena S. Leigh, M.D.


Pediatric Child Development & Behavior




  • Associate Physician Diplomate
  • Assistant Clinical Professor
To see if Mary Jacena S. Leigh is accepting new patients, or for assistance finding a UC Davis doctor, please call 800-2-UCDAVIS (800-282-3284).

UC Davis MIND Institute

2825 50th St.
Sacramento, CA 95817
Driving Directions

Primary Phone:

Additional Phone Numbers

Phone: 916-703-0300
Clinic Fax: 916-703-0243
Department Referral Phone: 800-482-3284

Clinical Interests

Dr. Leigh is interested in general child development, both typical and atypical, as well as in neurodevelopmental disorders including autism spectrum disorder and attention deficit hyperactivity disorder.  

She is also interested in developmental evaluations for infants and toddlers who are at high risk for developmental delays.

Research/Academic Interests

Dr. Leigh is involved in research aimed at developing targeted treatments for genetic and neurodevelopmental disorders.  She is currently a clinician in clinical trials and research studies for fragile X syndrome and autism spectrum disorder.


Child Development and Behavior

Center/Program Affiliation

UC Davis MIND Institute
UC Davis Children's Hospital


M.D., Geffen School of Medicine-UCLA, Los Angeles CA 2006

B.A., UC Berkeley, Berkeley CA 2011

Pediatrics, UC Davis Medical Center, Sacramento CA 2006-2007


Pediatrics, UC Davis Medical Center, Sacramento CA 2007-2009


Developmental and Behavioral Pediatrics, UC Davis MIND Institute, Sacramento CA 2009-2012

Board Certifications

American Board of Pediatrics, Developmental and Behavioral,

American Board of Pediatrics, General Pediatrics,

Professional Memberships

International Society for Autism Research

Phi Beta Kappa Honor Society

Society for Developmental and Behavioral Pediatrics

Society for the Scientific Study of Behavioral Phenotypes

Western Society for Pediatric Research

Honors and Awards

Conquer Fragile X Young Investigator Award, National Fragile X Foundation, 2012

Annual Meeting Travel Award, Pediatric Academic Society, 2012

Research and Abbott Nutrition, 2012

Jeanne Spurlock Clinical Fellowship, American Academy of Child and Adolescent, 2003

I.L. Chaikoff Memorial Award for Outstanding Achievement and Excellence in Molecular & Cell Biology/ Cell & Developmental Biology, University of California Berkeley, 2001

Select Recent Publications

Schneider A, Leigh MJ, Adams P, Nanakul R, Chechi T, Olichney J, Hagerman RJ, Hessl D. Electrocortical Changes Associated with Minocycline Treatment in Fragile X Syndrome. J Psychopharmacol. 2013 Oct;27(10):956-63. Epub 2013 Aug 27.

Dziembowska M, Pretto DI, Janusz A, Kaczmarek L, Leigh MJ, Gabriel N, Durbin-Johnson B, Hagerman RJ, Tassone F. High MMP-9 activity levels in fragile X syndrome are lowered by minocycline. Am J Med Genet A. 2013 Aug;161A(8):1897-903. Epub 2013 Jul 3.

Leigh MJ, Nguyen DV, Mu Y, Winarni TI, Schneider A, Chechi T, Polussa J, Doucet P, Tassone F, Rivera SM, Hessl D, Hagerman RJ. A randomized double-blind, placebo-controlled trial of minocycline in children and adolescents with fragile x syndrome. J Dev Behav Pediatr. 2013 Apr;34(3):147-55. 

Gianoukakis AG, Leigh MJ, Richards P, Christenson PD, Hakimian A, Fu P, Niihara Y, Smith TJ. Characterization of the anemia associated with Graves' disease. Clinical Endocrinology. 2009 May;70(5):781-7.

Machen TE, Leigh MJ, Taylor C, Kimura T, Asano S, Moore HP.  pH of TGN and recycling endosomes of H+/K+-ATPase-transfected HEK-293 cells: implications for pH regulation in the secretory pathway. Am J of Physiology- Cell Physiology. 2003 Jul;285 (1):C205-14. 

Leigh MJ, Partington L, Weeber E. Angelman Syndrome In Treatment of Neurodevelopmental Disorders- Targeting Neurobiological Mechanisms, eds. B Moghaddam, R Hagerman, and R Hendren, Oxford: Elsevier. 2014.

Leigh MJ, Hagerman RJ, Hessl, DR. Fragile X.  In Clinical Manual of Neurodevelopmental Disorders, eds. S. Rogers and R. Hansen, Arlington: American Psychiatric Publishing. 2012.

Hendrickson DJ, Knisely AS, Coulter K, Telander DG, Quan R, Ruebner BH, Leigh MJ. An inborn error of bile salt transport with features mimicking abusive head trauma. Child Abuse & Neglect. 2010 Jun 1.