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Division of Research
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Aijun Wang Ph.D.

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Aijun Wang, M.D.

Dr. Wang is an assistant professor of surgery. He is Co-Director of the Surgical Bioengineering Laboratory at UC Davis School of Medicine. Dr. Wang was trained in biology at Tsinghua University, China, and had undergone postdoctoral training at UC Berkeley Department of Bioengineering and Berkeley Stem Cell Center with a postdoctoral fellowship from California Institute for Regenerative Medicine (CIRM). He is a faculty member of UC Davis since 2012. Dr. Wang's research goal is to develop novel technologies that combine stem cell engineering and biomaterial engineering to promote tissue regeneration. One line of research is the study of stem cell contribution to vascular disease development (atherosclerosis etc.) and wound healing process (foreign body reaction and scar formation). Another line of research is the combination of stem cell engineering (stem cell identification, directed differentiation and delivery mechanisms) and biomaterial technology (nanomaterials, surface modification, biomolecule immobilization and drug delivery) for tissue regeneration.

Title: Assistant Professor
Co-Director, Surgical Bioengineering Laboratory
Specialty: Stem cell and bioengineering research
Center/Program Affiliation: Surgical Bioengineering Laboratory
Address: UC Davis Medical Center
4625 2nd Ave., Research II, Room 3005
Sacramento, CA 95817

Tsinghua University
Beijing, China
Ph.D. 2007

Shandong University
Jinan China
M.S. 2003

Shandong Medical University
Jinan China
B.S. 2000

Postdoctoral Training:

UC Berkeley
Berkeley, California, US

Berkeley Stem Cell Center
California Institute for Regenerative Medicine (CIRM)
Berkeley, California, US
Stem Cell Engineering

Professional Memberships: American Heart Association (AHA)
Materials Research Society (MRS)
Biomedical Engineering Society (BMES)
International Society for Stem Cell Research (ISSCR)
Honors and Awards: Finalist of Deloitte QB3 Award for Innovation, 2012
Winner Berkeley Venture Lab Competition, 2011
Tsinghua – Hengshanliangci Excellent Thesis Award, 2010
Select Recent Publications: Jian Yu*, Aijun Wang*, Zhenyu Tang, Yiqian Zhu, Jeffrey Henry, Fengping Huang, Song Li. The effect of stromal cell-derived factor-1α/heparin coating of biodegradable vascular grafts on the recruitment of both endothelial and smooth muscle progenitor cells for accelerated regeneration. Biomaterials. 2012 Nov; 33(32):8062-74. *Contributed equally.

Zhenyu Tang*, Aijun Wang*, Zhiqiang Yan, Bo Liu, Julia Chu, Jill Helms, Song Li. Differentiation of Multipotent Vascular Stem Cells Contributes to Vascular Diseases. Nature Communications. 2012 Jun 6; 3:875. *Contributed equally.

Timothy Downing*, Aijun Wang*, Zhiqiang Yan, Yvette Nout, Andy Lee, Michael S. Beattie, Jacqueline C. Bresnahan, Diana L. Farmer, Song Li. Drug-eluting microfibrous patches for the local delivery of rolipram in spinal cord repair. Journal of Controlled Release. 2012 May 23; 161(3):910-917. *Contributed equally.

Benjamin Lee, Hojeong Jeon, Aijun Wang, Zhiqiang Yan, Jian Yu, Costas Grigoropoulos, Song Li. Femtosecond Laser Ablation Enhances Cell Infiltration into Three-Dimensional Electrospun Scaffolds. Acta Biomaterialia. 2012 Jul; 8(7):2648-58.

Aijun Wang, Zhenyu Tang, Xian Li, Yisu Jiang, Danielle A. Tsou, Song Li. Derivation of Smooth Muscle Cells with Neural Crest Origin from Human Induced Pluripotent Stem Cells. Cells Tissues Organs. 2012; 195:5-14.

Payam Saadai, Yvette Nout, Jose Encinas, Aijun Wang, Timothy Downing, Michael S. Beattie, Jacqueline C. Bresnahan, Song Li, Diana L. Farmer. Prenatal Repair of Myelomeningocele with Aligned Nanofibrous Scaffolds - A Pilot Study in Sheep. The Journal of Pediatric Surgery. 2011; 46:2279-83.

Xian Li, Julia S. Chu, Aijun Wang, Yiqian Zhu, Wai Keung Chu, Li Yang, Song Li. Uniaxial Mechanical Strain Modulates the Differentiation of Neural Crest Stem Cells into Smooth Muscle Lineage on Micropatterned Surfaces. PLoS ONE. 2011; 6(10): e26029.

Yujun Wei, Kai Gong, Zhenghuan Zheng, Aijun Wang, Qiang Ao, Yandao Gong, Xiufang Zhang. Chitosan/silk Fibroin-based Tissue-engineered Graft Seeded with Adipose-derived Stem Cells Enhances Nerve Regeneration in a Rat Model. Journal of Materials Science: Materials in Medicine. 2011; 22(8):1947-64.

Aijun Wang, Zhenyu Tang, In-Hyun Park, Yiqian Zhu, Shyam Patel, George Q. Daley, Song Li. Induced Pluripotent Stem Cells for Neural Tissue Engineering. Biomaterials. 2011, 32(22):5023-32.
Jennifer S. Park, Anchi D. Tsou, Rokhaya Diop, Zhenyu Tang, Aijun Wang, Song Li. The Effect of Matrix Stiffness on the Differentiation of Mesenchymal Stem Cells in Response to TGF-β. Biomaterials. 2011, 32(16):3921-30.

Yiqian Zhu*, Aijun Wang*, Shyam Patel*, Kyle Kurpinski, Edward Diao, Xuan Bao, George Kwong, William L. Young, Song Li. Engineering Bi-layer Nanofibrous Conduits for Peripheral Nerve Regeneration. Tissue Engineering. 2011, 17(7):705-15. *Contributed equally.

Hayley Lam, Shyam Patel, Aijun Wang, Julia Chu, Song Li. Regulation of Neural Differentiation and Axon Growth by Growth Factors and Bioactive Nanofibers. Tissue Engineering. 2010, 16(8):2641-8.

Yujun Wei, Zhenghuan Zheng, Lingling Liu, Aijun Wang, Lihai Zhang, Qiang Ao, Yandao Gong, Xiufang Zhang. Schwann-like Cells Differentiation of Rat Adipose-derived Stem Cells by Indirect Co-culture with Schwann Cells in vitro. Cell Proliferation. 2010, 43(6):606-16.

Gan Wang, Qiang Ao, Kai Gong, Aijun Wang, Yandao Gong, Xiufang Zhang. The Effect of Topology of Chitosan Biomaterials on the Differentiation and Proliferation of Neural Stem Cells. Acta Biomaterialia. 2010, 6(9), 3630-9.

Yiqian Zhu*, Aijun Wang*, Wenqian Shen*, Shyam Patel, Rong Zhang, William Young, Song Li. Nanofibrous Patches for Spinal Cord Regeneration. Advanced Functional Materials. 2010, 20(9), 1433-40. *Contributed equally.

Kyle Kurpinski, Hayley Lam, Julia Chu, Aijun Wang, Ahra Kim, Eric Tsay, Smita Agrawal, David Schaffer, Song Li. TGF-β and Notch Signaling Mediate Stem Cell Differentiation into Smooth Muscle Cells. Stem Cells. 2010, 28(4), 734-42.

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