Paul Albert Sieving, M.D., Ph.D.
Inherited Retinal and Macular Dystrophies
Genetics of Eye Diseases
Dr. Paul A. Sieving is a professor at the UC Davis Eye Center and will hold the Neil and M.J. Kelly Presidential Endowed Chair in Vitreoretinal Research at UC Davis. He specializes in identifying the genetic cause of blinding, inherited diseases of the retina and macula to bring gene and cell therapies to patients. His team at the National Institutes of Health in Washington, D.C., is currently conducting a phase 1 human clinical trial of a gene therapy for X-linked retinoschisis, a condition that causes impaired vision that begins in childhood and occurs exclusively in males. This disorder affects the retina, the specialized light-sensitive tissue that lies at the back inside the eye.
Dr. Sieving is a leader whose exceptional research and initiatives as National Eye Institute director have launched a wave of innovation in the diagnosis and treatment of eye diseases that will guide physicians and scientists across the U.S. for years to come. At UC Davis, he will continue his focus on working with patients who have genetic retinal diseases and on developing fundamental approaches to repairing injured cells and tissues. His goal is to better understand eye diseases to develop cures for patients. He is an elected member of the U.S. National Academy of Medicine and also the German National Academy of Sciences, and has published more than 250 journals articles and book chapters.
M.D., University of Illinois Medical School, 1978
Ph.D., Biomedical Engineering, University of Illinois Graduate School, 1981
M.S., Physics, Yale University, New Haven CT 1973
J.D. Degree Program, Yale Law School, 1973-1974
B.A., Valparaiso University, Valparaiso IN 1970
Internship: University of Illinois Hospital, IL 1978-1979
Ophthalmology, University of Illinois Eye and Ear Infirmary, Chicago IL 1979-1982
Inherited Retinal Degenerations, Harvard Medical School, Cambridge MA 1984-1985
Retinal Physiology, UC San Francisco, San Francisco CA 1982-1984
American Board of Ophthalmology,
National Board of Medical Examiners, Diplomate,
Academia Ophthalmologica Internationalis
American Academy of Ophthalmology
American Association for the Advancement of Science
American Ophthalmological Society
American Society of Human Genetics
Association for Research in Vision & Ophthalmology
German Academy of Sciences- Leopoldina
International Society for Clinical Electrophysiology of Vision
Society for Neuroscience
The Retina Society
U.S. National Academy of Medicine
Honors and Awards
Visionary Award, Glaucoma Research Foundation, 2020
The German National Academy of Sciences, Elected, 2013
SOI Honorary Award in Ophthalmology, Societa Oftalmologica Italiana, Milan, Italy, 2016
Select Recent Publications
Heymann JB, Vijayasarathy C, Huang RK, Dearborn AD, Sieving PA, Steven AC. Cryo-EM of retinoschisin branched networks suggests an intercellular adhesive scaffold in the retina. J Cell Biol. 2019 Mar 4;218(3):1027-1038. Epub 2019 Jan 10.
Song H, Bush RA, Zeng Y, Qian H, Wu Z, Sieving PA. Trans-ocular Electric Current In Vivo Enhances AAV-Mediated Retinal Gene Transduction after Intravitreal Vector Administration. Mol Ther Methods Clin Dev. 2018 Dec 21;13:77-85.
Cukras C, Wiley HE, Jeffrey BG, Sen HN, Turriff A, Zeng Y, Vijayasarathy C, Marangoni D, Ziccardi L, Kjellstrom S, Park TK, Hiriyanna S, Wright JF, Colosi P, Wu Z, Bush RA, Wei LL, Sieving PA. Retinal AAV8-RS1 Gene Therapy for X-Linked Retinoschisis: Initial Findings from a Phase I/IIa Trial by Intravitreal Delivery. Mol Ther. 2018 Sep 5;26(9):2282-2294. Epub 2018 Jul 7.
Cukras CA, Huryn LA, Jeffrey BG, Turriff A, Sieving PA. Analysis of Anatomic and Functional Measures in X-Linked Retinoschisis. Invest Ophthalmol Vis Sci. 2018 Jun 1;59(7):2841-2847. Erratum in: Invest Ophthalmol Vis Sci. 2018 Aug 1;59(10):3868.
MacDonald IM, Sieving PA. Investigation of the effect of dietary docosahexaenoic acid (DHA) supplementation on macular function in subjects with autosomal recessive Stargardt macular dystrophy. Ophthalmic Genet. 2018 Aug;39(4):477-486. Epub 2018 Jun 18.
Allahdina AM, Stetson PF, Vitale S, Wong WT, Chew EY, Ferris FL III, Sieving PA, Cukras C. Optical Coherence Tomography Minimum Intensity as an Objective Measure for the Detection of Hydroxychloroquine Toxicity. Invest Ophthalmol Vis Sci. 2018 Apr 1;59(5):1953-1963.
Cukras C, Flamendorf J, Wong WT, Ayyagari R, Cunningham D, Sieving PA. LONGITUDINAL STRUCTURAL CHANGES IN LATE-ONSET RETINAL DEGENERATION. Retina. 2016 Dec;36(12):2348-2356.
Bush RA, Zeng Y, Colosi P, Kjellstrom S, Hiriyanna S, Vijayasarathy C, Santos M, Li J, Wu Z, Sieving PA. Preclinical Dose-Escalation Study of Intravitreal AAV-RS1 Gene Therapy in a Mouse Model of X-linked Retinoschisis: Dose-Dependent Expression and Improved Retinal Structure and Function. Hum Gene Ther. 2016 May;27(5):376-89.
Ou J, Vijayasarathy C, Ziccardi L, Chen S, Zeng Y, Marangoni D, Pope JG, Bush RA, Wu Z, Li W, Sieving PA. Synaptic pathology and therapeutic repair in adult retinoschisis mouse by AAV-RS1 transfer. J Clin Invest. 2015 Jul 1;125(7):2891-903. Epub 2015 Jun 22.
Marangoni D, Wu Z, Wiley HE, Zeiss CJ, Vijayasarathy C, Zeng Y, Hiriyanna S, Bush RA, Wei LL, Colosi P, Sieving PA. Preclinical safety evaluation of a recombinant AAV8 vector for X-linked retinoschisis after intravitreal administration in rabbits. Hum Gene Ther Clin Dev. 2014 Dec;25(4):202-11.
Zein WM, Falsini B, Tsilou ET, Turriff AE, Schultz JM, Friedman TB, Brewer CC, Zalewski CK, King KA, Muskett JA, Rehman AU, Morell RJ, Griffith AJ, Sieving PA. Cone responses in Usher syndrome types 1 and 2 by microvolt electroretinography. Invest Ophthalmol Vis Sci. 2014 Nov 25;56(1):107-14.
Zein WM, Jeffrey BG, Wiley HE, Turriff AE, Tumminia SJ, Tao W, Bush RA, Marangoni D, Wen R, Wei LL, Sieving PA. CNGB3-achromatopsia clinical trial with CNTF: diminished rod pathway responses with no evidence of improvement in cone function. Invest Ophthalmol Vis Sci. 2014 Sep 9;55(10):6301-8.
Cukras C, Huynh N, Vitale S, Wong WT, Ferris FL 3rd, Sieving PA. Subjective and objective screening tests for hydroxychloroquine toxicity. Ophthalmology. 2015 Feb;122(2):356-66. Epub 2014 Oct 14.
Sergeev YV, Vitale S, Sieving PA, Vincent A, Robson AG, Moore AT, Webster AR, Holder GE. Molecular modeling indicates distinct classes of missense variants with mild and severe XLRS phenotypes. Hum Mol Genet. 2013 Dec 1;22(23):4756-67. Epub 2013 Jul 11.