Dr. Yoon's clinical interest is diabetes mellitus.
Dr. Yoon is interested in molecular studies of metabolic regulation and human disease. Ongoing work utilizes a combination of experimental systems and approaches to investigate the roles of several molecules that his laboratory has identified as controlling energy balance in cells and organisms.
A sustained positive energy balance from excessive dietary intake and/or reduced energy expenditure results in obesity, predisposing to diabetes and other serious medical conditions. While most available anti-obesity drugs work by suppressing appetite, increasing energy expenditure via thermogenesis is an alternative and promising approach to improving energy balance. Conversely, certain human conditions such as cachexia or cystic fibrosis are characterized by a negative energy balance from inadequate nutrition and/or increased energy expenditure, lowering survival and compromising quality of life. A long-term goal of Dr. Yoon’s research program is to develop new therapeutic agents for human disorders associated with abnormally regulated energy balance. A related area of interest is the contribution of mitochondrial defects and inflammatory processes to the development of metabolic disease.
Endocrinology, Diabetes, and Metabolism
M.D., Harvard Medical School, Boston MA 2002
Ph.D., Harvard Graduate School, Boston MA 2002
A.B., Harvard University, Cambridge MA 1990
Internship: Internal Medicine, New York Presbyterian Hospital, New York NY 2002-2003
Internal Medicine, New York Presbyterian Hospital, New York NY 2003-2004
Genetics, Brigham and Women's Hospital, Boston MA 2007-2009
Endocrinology, Massachusetts General Hospital, Boston MA 2004-2007
American Board of Internal Medicine, 2015
American Board of Internal Medicine, Endocrinology, Diabetes and Metabolism, 2018
State of California, Medical license,
Honors and Awards
Damon Runyon Cancer Research Foundation Fellow, 2007
Leon Reznick Prize for Excellence in Research, Harvard Medical School, 2002
Select Recent Publications
Choi KM, Ryan KK, Yoon JC. Adipose Mitochondrial Complex I Deficiency Modulates Inflammation and Glucose Homeostasis in a Sex-Dependent Manner. Endocrinology. 2022 Apr 1;163(4):bqac018. doi:10.1210/endocr/bqac018. PMID:35171275.
Choi KM, Kim JH, Kong X, Isik M, Zhang J, Lim HW, Yoon JC. Defective brown adipose tissue thermogenesis and impaired glucose metabolism in mice lacking Letmd1. Cell Rep. 2021 Dec 14;37(11):110104. doi:10.1016/j.celrep.2021.110104. PMID:34910916.
Litvin M, Yoon JC, Leey Casella J, Blackman SM, Brennan AL. Energy balance and obesity in individuals with cystic fibrosis. J Cyst Fibros. 2019 Oct;18 Suppl 2:S38-S47. doi:10.1016/j.jcf.2019.08.015. PMID:31679728.
Yoon JC. Evolving Mechanistic Views and Emerging Therapeutic Strategies for Cystic Fibrosis-Related Diabetes. J Endocr Soc. 2017 Oct 30;1(11):1386-1400. doi:10.1210/js.2017-00362. PMID:29264462.
Yoon JC, Ling AJ, Isik M, Lee DY, Steinbaugh MJ, Sack LM, Boduch AN, Blackwell TK, Sinclair DA, Elledge SJ. GLTSCR2/PICT1 links mitochondrial stress and Myc signaling. Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3781-6. doi:10.1073/pnas.1400705111. Epub 2014 Feb 20. PMID:24556985.
Davoli T, Xu AW, Mengwasser KE, Sack LM, Yoon JC, Park PJ, Elledge SJ. Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome. Cell. 2013 Nov 7;155(4):948-62. doi:10.1016/j.cell.2013.10.011. Epub 2013 Oct 31. PMID:24183448.
Yoon JC, Ng A, Kim BH, Bianco A, Xavier RJ, Elledge SJ. Wnt signaling regulates mitochondrial physiology and insulin sensitivity. Genes Dev. 2010 Jul 15;24(14):1507-18. doi:10.1101/gad.1924910. PMID:20634317.
Puigserver P, Rhee J, Donovan J, Walkey CJ, Yoon JC, Oriente F, Kitamura Y, Altomonte J, Dong H, Accili D, Spiegelman BM. Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. Nature. 2003 May 29;423(6939):550-5. doi:10.1038/nature01667. Epub 2003 May 18. PMID:12754525.
Yoon JC, Puigserver P, Chen G, Donovan J, Wu Z, Rhee J, Adelmant G, Stafford J, Kahn CR, Granner DK, Newgard CB, Spiegelman BM. Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature. 2001 Sep 13;413(6852):131-8. doi:10.1038/35093050. PMID:11557972.