John Yoon, M.D., Ph.D.

John C. Yoon, M.D., Ph.D.


Endocrinology, Diabetes, and Metabolism

Internal Medicine


Internal Medicine


  • Assistant Professor


To see if John C. Yoon is accepting new patients, or for assistance finding a UC Davis doctor, please call 800-2-UCDAVIS (800-282-3284).

Lawrence J. Ellison Ambulatory Care Center

4860 Y St., Suite 0400
Sacramento, CA 95817
Driving Directions

Primary Phone:

Additional Phone Numbers

Clinic Fax: 916-734-5484
Physician Referrals: 800-4-UCDAVIS (800-482-3284)

Clinical Interests

Dr. Yoon's clinical interest is Diabetes Mellitus.

Research/Academic Interests

Dr. Yoon is interested in molecular studies of metabolic regulation and human disease.  Ongoing work utilizes a combination of experimental systems and approaches to investigate the roles of several molecules that his laboratory has identified as controlling energy balance in cells and organisms.

A sustained positive energy balance from excessive dietary intake and/or reduced energy expenditure results in obesity, predisposing to diabetes and other serious medical conditions.   While most available anti-obesity drugs work by suppressing appetite, increasing energy expenditure via thermogenesis is an alternative and promising approach to improving energy balance.  Conversely, certain human conditions such as cachexia or cystic fibrosis are characterized by a negative energy balance from inadequate nutrition and/or increased energy expenditure, lowering survival and compromising quality of life.   A long-term goal of Dr. Yoon’s research program is to develop new therapeutic agents for human disorders associated with abnormally regulated energy balance.  A related area of interest is the contribution of mitochondrial defects and inflammatory processes to the development of metabolic disease.


Endocrinology, Diabetes, and Metabolism


M.D., Harvard Medical School, Boston MA 2002

Ph.D., Harvard Graduate School, Boston MA 2002

A.B., Harvard University, Cambridge MA 1990

Internship: Internal Medicine, New York Presbyterian Hospital, New York NY 2002-2003


Internal Medicine, New York Presbyterian Hospital, New York NY 2003-2004


Genetics, Brigham and Women's Hospital, Boston MA 2007-2009

Endocrinology, Massachusetts General Hospital, Boston MA 2004-2007

Board Certifications

American Board of Internal Medicine, 2015

American Board of Internal Medicine, Endocrinology, Diabetes and Metabolism, 2018

State of California, Medical license,

Honors and Awards

Damon Runyon Cancer Research Foundation Fellow, 2007

Leon Reznick Prize for Excellence in Research, Harvard Medical School, 2002

Select Recent Publications

Yoon JC. Evolving mechanistic views and emerging therapeutic strategies for cystic fibrosis-related diabetes. Journal of the Endocrine Society. 2017;1:1386-1400.

Yoon JC, Ling AL, Isik M, Lee DD, Steinbaugh MJ, Sack LM, Boduch AN, Blackwell TK, Sinclair DA, Elledge SJ. GLTSCR2/PICT-1 links mitochondrial stress and Myc signaling. Proc Natl Acad Sci USA. 2014;111:3781-3786.

Davoli T, Xu W, Mengwasser KE, Sack LM, Yoon JC, Park PJ, Elledge SJ. Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome. Cell. 2013;155:948-962.

Yoon JC, Ng A, Kim BH, Bianco A, Xavier RJ, Elledge SJ. Wnt signaling regulates mitochondrial physiology and insulin sensitivity. Genes Dev. 2010;24:1507-1518.

Puigserver, P, Rhee J, Donovan J, Walkey CJ, Yoon JC, Oriente F, Kitamura Y, Altomonte J, Dong H, Accili, and Spiegelman BM. Insulin-Regulated Hepatic Gluconeogenesis through FOXO1-PGC-1α Interaction. Nature. 2003;423(6939):550-555.

Yoon JC, Puigserver P, Chen G, Wu Z, Rhee J, Adelmant G, Stafford J, Kahn CR, Granner DK, Newgard CB, and Spiegelman BM. Control of Hepatic Gluconeogenesis through the Transcriptional Coactivator PGC-1. Nature. 2001;413:131-138.