Bennett Penn, M.D., Ph.D.

Bennett H. Penn, M.D., Ph.D.


Infectious Diseases


Internal Medicine


  • Assistant Professor


To see if Bennett H. Penn is accepting new patients, or for assistance finding a UC Davis doctor, please call 800-2-UCDAVIS (800-282-3284).

Lawrence J. Ellison Ambulatory Care Center

4860 Y St., Suite 0101
Sacramento, CA 95817
Driving Directions

Primary Phone:

Additional Phone Numbers

Physician Referrals: 800-4-UCDAVIS (800-482-3284)





Clinical Interests

Dr. Penn is an infectious diseases specialist caring for adult patients with a wide range of complex infections. He has particular expertise and research interest in mycobacterial diseases such as Tuberculosis.

Research/Academic Interests

Dr. Penn's research focuses on understanding the immune response to Mycobacterium tuberculosis, the bacteria that causes the human disease tuberculosis using cutting-edge genetic and proteomic tools.


Infectious Diseases


M.D., University of Washington School of Medicine, Seattle WA 2006

Ph.D., Molecular Biology, University of Washington/ Fred Hutchinson Cancer Center, Seattle WA 2004

B.A., Northwestern University, Evanston IL 1997

Internship: Internal Medicine, Stanford University Hospital, Stanford CA 2006-2007


Internal Medicine, Stanford University Hospital, Stanford CA 2007-2009


Infectious Diseases, UC San Francisco Medical Center, San Francisco CA 2009-2011

Board Certifications

American Board of Internal Medicine, 2009

American Board of Internal Medicine, Infectious Disease, 2011

Honors and Awards

Chief Fellow, infectious diseases fellowship, University of California San Francisco, 2010

Clinical Excellence Award, top internal medicine resident clinician, Stanford Hospital, 2009

Select Recent Publications

Penn BH, Netter Z, Johnson, J. Ohol Y, Maher C., Bell S, Von Dollen J, Geiger K, Du X, Choi A, Parry T, Naramura M, Jang G, Johnson T, Chen C, Jaeger S, Shales M, Portnoy D, Hernandez R, Coscoy L, Krogan NJ and Cox JS. A Mtb-Human Protein-Protein Interaction Map Reveals a Role for the Ubiquitin Ligase CBL in Regulating the Balance Between Host Anti-Viral and Anti-Bacterial Responses. Mol. Cell. Preprint: bioRxiv

Penn BH and Cox JS. Immunology: Organelle stress triggers inflammation. Nature. 2016 April;21:532, 321–322.

Mirrashidi, K, Engel, J, Verschueren, E, Johnson, JR, Frando, A, Von Dollen, J, Rosenberg,R, Gulbahce, N, Jang, G, Johnson, J, Jager, S, Gopalakrishnan, A, Dunn, JD, Olive, A, Penn, B, Shales, M, Starnbach, M, Derre, I, Valdivia, R, Krogan, N, Engel, J. Global analysis of Chlamydia Inc-host protein interactome reveals that retromer functions as a host restriction factor. Cell Host & Microbe. 2015 July; 8(18):109–121.

Ercegovac UC, Metcalfe TL, Penn BH, Smith KM, Elmore JG. Traveling as a risk factor for venous thromboembolic disease. Respir Care. 2006 Oct;51(10):1177–80.

Cao Y, Kumar RM, Penn BH, Berkes CA, Kooperberg C, Boyer LA, Young RA, and Tapscott SJ. Global and gene-specific analyses show distinct roles for Myod and Myog at a common set of promoters. EMBO J. 2006 Feb 8;25(3):502–11.

Penn BH, Bergstrom DA, Dilworth FJ, Bengal E, Tapscott SJ. A MyoD-generated feed-forward circuit temporally patterns gene expression during skeletal muscle differentiation. Genes Dev. Cold Spring Harbor Lab. 2004 Oct 1;18(19):2348–53.

Berkes CA, Bergstrom DA, Penn BH, Seaver KJ, Knoepfler PS, Tapscott SJ. Pbx marks genes for activation by MyoD indicating a role for a homeodomain protein in establishing myogenic potential. Mol Cell. 2004 May 21;14(4):465–77.

Penn BH*, Bergstrom DA*, Strand A, Perry RLS, Rudnicki MA, Tapscott SJ. Promoter-specific regulation of MyoD binding and signal transduction cooperate to pattern gene expression. Mol Cell. 2002 Mar;9(3):587–600. *These authors contributed equally to this work 

Filippova GN, Thienes CP, Penn BH, Cho DH, Hu YJ, Moore JM, et al. CTCF-binding sites flank CTG/CAG repeats and form a methylation-sensitive insulator at the DM1 locus. Nat Genet. Nature Publishing Group. 2001 Aug;28(4):335–43.

Penn BH, Berkes CA, Bergstrom DA, Tapscott SJ. How to MEK muscle. Mol Cell. 2001 Aug;8(2).