Dalyir I. Pretto, Ph.D.

Specialties

Stem Cell Biology

Molecular Genetics

Biochemistry

Department

Internal Medicine

Title

  • Assistant Project Scientist

Reviews

Research/Academic Interests

Dr. Pretto’s research examines the effect of the extracellular matrix microenvironment on sub-type fate determination and maturation of hiPSC-derived cardiomyocytes, using tissue engineering and small molecule directed differentiation methods.

Division

Cardiovascular Medicine

Education

Ph.D., Vanderbilt University, Nashville TN 2010

B.S., University of Nebraska. Omaha NE 2000

Honors and Awards

UC Davis Travel Award, UC Davis CA, 2014

CIRM Postdoctoral Fellowship,UC Davis CA, 2014

NTRI Postdoctoral Fellowship, UC Davis CA, 2010

Ruth�s Kirschtein National Research Service Award, Vanderbilt University TN, 2004, 2006

Select Recent Publications

Pretto, D., Maar, D. Yrigollen, C., Reagan, J. and Tasone F.  “Screening newborn blood spots for 22q11.2 deletion syndrome using multiplex droplet digital PCR”. Clin Chem. 2015 Jan;61(1):182-190.

Pretto, D., Eid JS., Tang H-T., Yrigollen CM, Loomis EW., Raske C., Durbin-Johnson B, Hagerman PJ., Tassone F.  "Differential Increases of specific FMR1 mRNA isoforms in premutation carriers". J Med Genet. 2015 Jan; 52(1)42-52.

Pretto, D., Yrigollen, CM., Tang H-T., Willianson J., Espinal G.,  Iwahashi C.K, Hagerman R., Durbin-Johnson B., Hagerman PJ., Tassone F. " Clinical and molecular implications of mosaicism in FMR1 full mutation". Frontiers in Genetics. 2014 Sep 17;(5):318.

Berman, R.F., R.A. Buijsen, K. Usdin, E. Pintado, R.F. Kooy, D. Pretto, I. N. Pessah, D. Nelson, Z. Zalewski, N. Charlet-Berguerand, R. Willemsen, R. Hukema. "Mouse Models of the fragile X premutation and fragile X-associated tremor/ataxia syndrome".  Journal of Neurodevelopmental Disorders. 2014;6(1): 25.

Pretto, D., M. Kumar, Z. Cao, C. L. Cunningham, B. Durbin-Johnson, L. Qi, R. Berman, S. C. Noctor, R. J. Hagerman, I. N. Pessah and F. Tassone. "Reduced excitatory amino acid transporter 1 and metabotropic glutamate receptor 5 expressions in the cerebellum of fragile X mental retardation gene 1 premutation carrier with fragile X-associated tremor/ataxia syndrome". Neurobiology of Aging. 2014 May;35(5):1189-97. Epub 2013 Nov 16.

Dziembowska, M., D., Pretto, A. Janusz, M. J. Leigh, N. Gabriel, B. Durbin-Johnson, R. J. Hagerman, and F. Tassone. "Minocycline lowers MMP9 in Fragile X syndrome". American Journal of Medical Genetics. 2013 Aug;161A(8):1897-1903.

Cao, Zhengyu, S, Hulsizer, D. Pretto, K. Kyung Ho, P. Hagerman, F. Tassone, I. Pessah.  "Enhanced asynchronous Ca2+ oscillations associated with glutamate transport in cortical astrocytes expressing Fmr1 premutation expansion". Journal of Biological Chemistry. 2013 May 10;288(19):13831-13841.

Pretto D., Tsutakawa S., Brosey C., Castillo A., Chagot M. E., Smith J., Tainer J., and Chazin W. J. “Structural Dynamics and single-stranded DNA binding activity of the three N-terminal domains of Replication Protein A from Small Angle X-ray Scattering”. Biochemistry. 2010 Apr 6;49(13):2880-2889.

Brosey C. A., Chagot M. E., Ehrhardt M., Pretto D. I., Weiner B. E., Chazin W. J. “NMR analysis of the architecture and functional remodeling of a modular multidomain protein, RPA”. Journal of American Chemical Society 2009. May 13;131(18):6346-6347.

Brosey C. A., Chagot M. E., Ehrhardt M., Pretto D. I., Weiner B. E., Chazin W. J. “NMR analysis of the architecture and functional remodeling of a modular multidomain protein, RPA”. Journal of American Chemical Society. 2009 May 13;131(18):6346-6347.