Elena Goncharova, Ph.D.

Elena Goncharova, Ph.D.

Specialties

Pulmonary Medicine

Clinical Research

Department

Internal Medicine

Title

  • Director, Pulmonary Vascular Disease Program
  • Professor, Department of Medicine

Reviews

Clinical Interests

Elena Goncharova is a Professor of Medicine at the University of California Davis School of Medicine. She received her undergraduate degree from Moscow State University, PhD from Russian Academy of Science, and completed postdoctoral training at the University of Pennsylvania School of Medicine. She has been a Research Assistant Professor at the University of Pennsylvania and Associate Professor of Medicine and Bioengineering at the University of Pittsburgh School of Medicine.

Research/Academic Interests

Dr. Goncharova has a long standing interest in basic and translational pulmonary vascular research and she serves as a Director of Pulmonary Vascular Disease Program. Dr. Goncharova’s research interests has focused on molecular and cellular mechanisms of pulmonary arterial hypertension (PAH) with specific focus on the role mTOR, HIPPO and GATA6 signaling networks and cancer-like smooth muscle remodeling in PAH as well as on identifying novel molecular targets to reverse established pulmonary vascular disease.

Division

Pulmonary, Critical Care, and Sleep Medicine

Education

Ph.D., Russian Academy of Sciences, Moscow, Russia 2000

M.S., Moscow Lomonosov State University, Moscow, Russia 1993

Professional Memberships

American Thoracic Society (ATS)

Pulmonary Vascular Research Institute

Honors and Awards

The AJRCCM Eminent Reviewer Award, American Thoracic Society, 2019

Conferral of Tenure, University of Pittsburgh School of Medicine, 2017

University of Pittsburgh VMI-HVI Innovator Award, Vascular Medicine Institute, University of Pittsburgh, 2014

LAM Foundation Francis G. Byrnes Conference Award, The LAM Foundation, 2013

Department of Medicine Robert Austrian Award in Bench Research, University of Pennsylvania Department of Medicine, 2012

American Lung Association Biomedical Research Award, American Lung Association, 2011

Gilead Sciences Research Scholars Award in Pulmonary Arterial Hypertension (PAH) Gilead, 2010

ATS/LAM Foundation Research Award, American Thoracic Society and The LAM Foundation, 2008

Parker B. Francis Fellowship Award, Parker B. Francis Fellowship Program, 2008

LAM Foundation Fellowship Award, The LAM Foundation, 2005

Junior Scientist of Russia Fellowship Award, Russian Federation for Basic Research, 2001

Select Recent Publications

Complete list of published work (Pubmed): http://www.ncbi.nlm.nih.gov/sites/myncbi/elena.goncharova.1/bibliography/43883529/public/?sort=date&direction=ascending

Goncharova EA, Chan SY, Ventetuolo SE, Weissmann N, Schermuly RT, Mullin CJ, Gladwin MT. Update in pulmonary vascular diseases and right ventricular dysfunction in 2019. American Journal of Respiratory and Critical Care Medicine. 2020;202(1):22-28.

Goncharova EA, Simon MA, Yuan JXJ. mTORC1 in Pulmonary Arterial Hypertension: at the crossroads between vasoconstriction and vascular remodeling? American Journal of Respiratory and Critical Care Medicine. 2020;201(10):1177-1179.

Goncharov DA, Goncharova EA, Tofovic SP, Hu J, Baust JJ, Pena AZ, Ray A, Rode A, Vanderpool RR, Mora AL, Gladwin MT, Lai YC. Metformin Therapy for Pulmonary Hypertension Associated with HFpEF versus PAH. American Journal of Respiratory and Critical Care Medicine. 2018;198(5):681-684.

Pullamsetti SS, Savai R, Seeger W, Goncharova EA. Translational Advances in the field of Pulmonary Hypertension. From cancer biology to new PAH therapeutics: Targeting cell growth and proliferation signaling hubs. American Journal of Respiratory and Critical Care Medicine. 2017;195(4):425-437.

Kudryashova TV, Goncharov DA, Pena A, Kelly N, Vanderpool R, Baust J, Kobir A, Shufesky W, Mora AL, Morelli AE, Zhao J, Ihida-Stansbury K, Chang B, DeLisser H, Tuder RM, Kawut SM, Silljé HHW, Shapiro S, Zhao Y, Goncharova EA. HIPPO-integrin linked kinase crosstalk controls self-sustaining proliferation and survival in pulmonary hypertension. American Journal of Respiratory and Critical Care Medicine. 2016;194(7):866-877.

Goncharov DA, Kudryashova TV, Ziai H, Ihida-Stansbury K, DeLisser H, Krymskaya VP, Tuder RM, Kawut SM, Goncharova EA. mTORC2 coordinates pulmonary artery smooth muscle cell metabolism, proliferation and survival in pulmonary arterial hypertension. Circulation. 2014;129(8):864-74.

Goncharova EA, Goncharov DA, James ML, Atochina-Vasserman EN, Stepanova V, Hong S-B, Li H, Gonzales L, Baba M, Linehan WM, Gow AJ, Margulies S, Guttentag S, Schmidt L, Krymskaya VP. Folliculin controls lung alveolar enlargement and epiteliak cell survival through E-cadherin, LKB1, and AMPK. Cell Reports. 2014;7(2):412-23.

Goncharova EA. mTOR and vascular remodeling in lung diseases: current challenges and therapeutic prospects. The FASEB Journal. 2013;27(5):1796-1807.

Goncharova EA, Goncharov DA, Fehrenbach M, Khavin I, Ducka B, Hino O, Colby TV, Merrilees MJ, Haczku A, Albelda SM, Krymskaya VP. Prevention of Alveolar Destruction and Airspace Enlargement in a Mouse Model of Pulmonary Lymphangioleiomyomatosis (LAM). Science Translational Medicine. 2012;4(154):154ra134.

Krymskaya VP, Snow J, Cesarone G, Khavin I, Goncharov DA, Lim PN, Veasey SC, Ihida-Stansbury K, Jones PL, Goncharova EA. mTOR is Required for Pulmonary Arterial Vascular Smooth Muscle Cell Proliferation Under Chronic Hypoxia. The FASEB Journal. 2011;25(6):1922-1933.