Tokihiro Yamamoto, M.S., Ph.D.



Medical Physics

Radiation Oncology


Radiation Oncology


To see if Tokihiro Yamamoto is accepting new patients, or for assistance finding a UC Davis doctor, please call 800-2-UCDAVIS (800-282-3284).

UC Davis Comprehensive Cancer Center

4501 X St.
Sacramento, CA 95817
Driving Directions

Primary Phone:

Additional Phone Numbers

Clinic Phone: 800-362-5566
Physician Referrals: 800-4-UCDAVIS (800-482-3284)

Research/Academic Interests

Dr. Yamamoto's scientific interests focus on developing and investigating novel imaging technologies and integrating these innovations into clinical radiotherapy to improve therapeutic gains in cancer radiotherapy.

Areas of active research include: (1) the development of lung ventilation/perfusion imaging based on computed tomography (CT) and deformable image registration, and applications in lung cancer radiotherapy to reduce pulmonary toxicity, and (2) the investigation of radiomics, an emerging method that applies advanced mathematical algorithms to extract quantitative features predictive of gene expression or clinical outcomes from imaging data, toward personalized radiotherapy.


Radiation Oncology

Center/Program Affiliation

UC Davis Comprehensive Cancer Center


M.S., Osaka University, Suita, Osaka, Japan 2004

Ph.D., Osaka University, Suita, Osaka, Japan 2007

B.S., Osaka University, Suita, Osaka, Japan 2002


Stanford University, Stanford CA 2011

Board Certifications

American Board of Radiology, Therapeutic Radiological Physics,

Japanese Board of Medical Physics (JBMP),

Professional Memberships

American Association of Physicists in Medicine (AAPM)

American Society for Radiation Oncology (ASTRO)

Japan Society of Medical Physics (JSMP)

Japan Society of Pulmonary Functional Imaging

Japanese Society for Therapeutic Radiology and Oncology (JASTRO)

Honors and Awards

Received Basic/Translational Abstract Award from ASTRO, 2016

Science Council Session, the American Association of Physicists in Medicine (AAPM), 2013

Young Scientist Sponsorship, European Respiratory Society (ERS), 2011

Scientific Presentation Award, International Workshop for Pulmonary Functional Imaging, 2011

John S. Laughlin Science Council Research Symposium, American Association of Physicists in Medicine (AAPM), 2010

Select Recent Publications

Dyer BA, Campos DD, Hernandez DD, Wright CL, Perks JR, Lucero SA, Bewley AF, Yamamoto T, Zhu X, Rao SS. Characterization and clinical validation of patient-specific three-dimensional printed tissue-equivalent bolus for radiotherapy of head and neck malignancies involving skin. Phys Med. 2020 Sep;77:138–145. doi:10.1016/j.ejmp.2020.08.010. Epub 2020 Aug 20. PMID:32829102.

Fujita Y, Kent M, Wisner E, Johnson L, Stern J, Qi L, Boone J, Yamamoto T. Combined Assessment of Pulmonary Ventilation and Perfusion with Single-Energy Computed Tomography and Image Processing. Acad Radiol. 2020 Jun 10;S1076-6332(20)30196-3. doi:10.1016/j.acra.2020.04.004. Online ahead of print. PMID:32534966.

Nakajima Y, Kadoya N, Kimura T, Hioki K, Jingu K, Yamamoto T. Variations Between Dose-Ventilation and Dose-Perfusion Metrics in Radiation Therapy Planning for Lung Cancer. Advan Radiat Oncol. 2020 May-Jun;5(3):459–465. doi:10.1016/j.adro.2020.03.002. Published online 2020 Mar 20.

Shin DS, Kang SH, Kim KH, Kim TH, Kim DS, Chung JB, Lucero SA, Suh TS, Yamamoto T. Development of a deformable lung phantom with 3D-printed flexible airways. Med Phys. 2020 Mar;47(3):898–908. doi:10.1002/mp.13982. Epub 2020 Jan 20. PMID:31863479.

Yuan Z, Rong Y, Benedict SH, Daly ME, Qiu J, Yamamoto T. "Dose of the day" based on cone beam computed tomography and deformable image registration for lung cancer radiotherapy. J App Clin Med Phys. 2020 Jan;21(1):88–94. doi:10.1002/acm2.12793. Epub 2019 Dec 9. PMID:31816170.

Shi L, Rong Y, Daly M, Dyer B, Benedict S, Qiu J, Yamamoto T. Cone-beam computed tomography-based delta-radiomics for early response assessment in radiotherapy for locally advanced lung cancer. Phys Med Biol. 2020 Jan 9;65(1):015009. doi:10.1088/1361-6560/ab3247. PMID:31307024.

Hegi-Johnson F, de Ruysscher D, Keall P, Hendriks L, Vinogradskiy Y, Yamamoto T, Tahir B, Kipritidis J. Imaging of regional ventilation: Is CT ventilation imaging the answer? A systematic review of the validation data. Radiother Oncol. 2019 Aug;137:175–185. doi:10.1016/j.radonc.2019.03.010. Epub 2019 May 23. PMID:31129503.

Kipritidis J, Tahir BA, Cazoulat G, Hofman MS, Siva S, Callahan J, Hardcastle N, Yamamoto T, Christensen GE, Reinhardt JM, Kadoya N, Patton TJ, Gerard SE, Duarte I, Archibald-Heeren B, Byrne M, Sims R, Ramsay S, Booth JT, Eslick E, Hegi-Johnson F, Woodruff HC, Ireland RH, Wild JM, Cai J, Bayouth JE, Kristy Brock K, Keall PJ. The VAMPIRE challenge: A multi-institutional validation study of CT ventilation imaging. Med Phys. 2019 Mar;46(3):1198–1217. doi:10.1002/mp.13346. Epub 2019 Feb 1. PMID:30575051.

Pinkham DW, Negahdar M, Yamamoto T, Mittra E, Diehn M, Nair VS, Keall PJ, Maxim PG, Loo BW Jr. A Feasibility Study of Single-inhalation, Single-energy Xenon-enhanced CT for High-resolution Imaging of Regional Lung Ventilation in Humans. Acad Radiol. 2019 Jan;26(1):38–49. doi:10.1016/j.acra.2018.03.006. Epub 2018 Mar 29. PMID:29606339.

Yamamoto T, Kabus S, Bal M, Bzdusek K, Keall PJ, Wright C, Benedict SH, Daly ME. Changes in Regional Ventilation During Treatment and Dosimetric Advantages of CT Ventilation Image Guided Radiation Therapy for Locally Advanced Lung Cancer. Int J Radiat Oncol Biol Phys. 2018 Nov 15;102(4):1366–1373. Published online 2018 May 4. doi:10.1016/j.ijrobp.2018.04.063. PMID:29891207.