Dr. Perks is a physicist whose clinical interests include stereotactic radiotherapy as well as radiosurgery planning and treatment delivery. In particular, he has been focusing on the commissioning and clinical integration of a new gamma-knife system for the treatment of intracranial lesions. He also is working to expand the department's intensity-modulated radiotherapy (IMRT) capabilities. Dr. Perks's research activities include the comparison of linear accelerator and gamma knife-based radiosurgery procedures, optimizing imaging protocols, and the retrospective analysis of cone beam CR predictive outcome models to develop data for UC Davis. As a researcher, he does not see patients.
Ph.D., University of Birmingham, Birmingham, UK 1996
B.Sc., University of Birmingham, Birmingham, UK 1993
American Board of Radiology, Therapeutic Radiological Physics,
American Association of Physicists in Medicine (AAPM)
American Society of Therapeutic Radiation Oncology (ASTRO)
CA state Department of Public Health approval for radiation shielding, therapy machine calibrations and radiation protection
Society Directors Academic Medical Physics Programs (SDAMPP)
Honors and Awards
Elected as President of San Francisco Bay Area AAPM Chapter, 2012
Select Recent Publications
Dyer BA, Campos DD, Hernandez DD, Wright CL, Perks JR, Lucero SA, Bewley AF, Yamamoto T, Zhu X, Rao SS. Characterization and clinical validation of patient-specific three-dimensional printed tissue-equivalent bolus for radiotherapy of head and neck malignancies involving skin. Phys Med. 2020 Sep;77:138–145. doi:10.1016/j.ejmp.2020.08.010. Epub 2020 Aug 20. PMID:32829102.
Dyer BA, Nair CK, Deardorff CE, Wright CL, Perks JR, Rao SS. Linear Accelerator-Based Radiotherapy Simulation Using On-Board Kilovoltage Cone-Beam Computed Tomography for 3-Dimensional Volumetric Planning and Rapid Treatment in the Palliative Setting. Techol Cancer Res Treat. 2019;18:1533033819865623. Published online 2019 Aug 1. doi:10.1177/1533033819865623. PMID:31370760.
Hartl BA, Ma H, Hansen KS, Perks J, Kent MS, Fragoso RC, Marcu L. The effect of radiation dose on the onset and progression of radiation-induced brain necrosis in the rat model. Int J Radiat Biol. 2017 Jul;93(7):676–682. Published online 2017 Mar 17. doi:10.1080/09553002.2017.1297902. PMID:28306402.
Monjazeb AM, Kent MS, Grossenbacher SK, Mall C, Zamora AE, Mirsoian A, Chen M, Kol A, Shiao SL, Reddy A, Perks JR, Culp W, Sparger EE, Canter RJ, Sckisel GD, Murphy WJ. Blocking Indolamine-2,3-Dioxygenase Rebound Immune Suppression Boosts Antitumor Effects of Radio-Immunotherapy in Murine Models and Spontaneous Canine Malignancies. Clin Cancer Res. 2016 Sep 1;22(17):4328–4340. Published online 2016 Mar 15. doi:10.1158/1078-0432.CCR-15-3026. PMID:26979392. PMID:26979392.
Miyamoto J, Michaud AL, Harandi NK, Kim EJ, Semrad T, Khatri V, Mayadev J, Perks J, Monjazeb AM. The Role of Image-guided Radiotherapy in the Treatment of Anorectal Cancer Using Prone Belly-board Positioning. Anticancer Res. 2016 May 31;36(6):3013–3017. PMID:27272819.
Liu R, Fan M, Candas D, Qin L, Zhang X, Eldridge A, Zou JX, Zhang T, Juma S, Jin C, Li RF, Perks J, Sun LQ, Vaughan AT, Hai CX, Gius DR, Li JJ. CDK1-Mediated SIRT3 Activation Enhances Mitochondrial Function and Tumor Radioresistance. Mol Cancer Ther. 2015 Sep;14(9):2090-102. doi:10.1158/1535-7163.MCT-15-0017. Epub 2015 Jul 3. PMID:26141949.
Perks JR, Lucero S, Monjazeb AM, Li JJ. Anthropomorphic Phantoms for Confirmation of Linear Accelerator-Based Small Animal Irradiation. Cureus. 2015 Mar 5;7(3):e254. Published online 2015 Mar 5. doi:10.7759/cureus.254. PMID:26180678.
Daly ME, Perks JR, Chen AM. Patterns-of-care for thoracic stereotactic body radiotherapy among practicing radiation oncologists in the United States. J Thorac Oncol. 2013 Feb;8(2):202-7. doi:10.1097/JTO.0b013e318279155f. PMID:23222368.
Healy E, Anderson S, Cui J, Beckett L, Chen AM, Perks J, Stern R, Mayadev J. Skin dose effects of postmastectomy chest wall radiation therapy using brass mesh as an alternative to tissue equivalent bolus. Pract Radiat Oncol. 2013 Apr-Jun;3(2):e45-53. doi:10.1016/j.prro.2012.05.009. Epub 2012 Jun 27. PMID:24674320.
Chen AM, Farwell DG, Luu Q, Donald PJ, Perks J, Purdy JA. Evaluation of the planning target volume in the treatment of head and neck cancer with intensity-modulated radiotherapy: what is the appropriate expansion margin in the setting of daily image guidance? Int J Radiat Oncol Biol Phys. 2011 Nov 15;81(4):943-9. doi:10.1016/j.ijrobp.2010.07.017. Epub 2010 Oct 6. PMID:20932680.