Oxybutynin for Post-Surgical Bladder Pain and Urgency

Description of Research Study: Bladder pain and urgency are common after bladder surgery. Our objective is to determine if transdermal administration is superior to oral administration in alleviating pain and urgency.
Principal Investigator: Eric Kurzrock, M.D., F.A.A.P., Department of Urologic Surgery
Research Coordinator: Anjali Vij, Department of Urologic Surgery

Pediatric Renal Trauma

Description of Research Study: We are studying to see if patient, surgical or anatomical factors impact outcomes after severe renal trauma.
Principal Investigator: Eric Kurzrock, M.D., F.A.A.P., Department of Urologic Surgery
Research Coordinator: Anjali Vij, Department of Urologic Surgery

A Randomized Study of Enzalutamide in Patients with Localized Prostate Cancer Undergoing Active Surveillance (ENACT)

Description of Research Study: The purpose of this research study is to find out how effective and safe Enzalutamide is to delay the progression of early stage prostate cancer. This will be compared with Active Surveillance (AS), also known as “watchful waiting,” where men are treated only if they develop symptoms from their cancer.
Principal Investigator: Christopher P. Evans, M.D., F.A.C.S., Department of Urologic Surgery
Co-Investigator: Marc Dall'Era, M.D., Department of Urologic Surgery
Research Coordinator: Anjali Vij, Department of Urologic Surgery

A Selective Frontline Cabazitaxel Therapeutic Pathway for Castration-Resistant Prostate Cancer with Integrated Biomarkers

Description of Research Study: This phase II trial studies how well cabazitaxel and prednisone work in treating patients with hormone-resistant prostate cancer that has spread to other parts of the body. Drugs used in chemotherapy, such as cabazitaxel and prednisone, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading.
Principal Investigator: Christopher P. Evans, M.D., F.A.C.S., Department of Urologic Surgery
Co-Investigator: Primo Lara, M.D., Department of Internal Medicine, Division of Hematology Oncology
Research Coordinator: Daniel Robles, UC Davis Comprehensive Cancer Center

Assessing the Quality of Care in Patients on Testosterone Replacement at UC Davis Health

Description of Research Study: This study will look to define at what levels of serum testosterone practitioners are initiating testosterone replacement and how we can help reveal the degree of testosterone use and monitoring in our institution.
Principal Investigator: Raul Clavijo, Department of Urologic Surgery
Research Coordinator: Anjali Vij, Department of Urologic Surgery

Enzalutamide and Metformin Combination Therapy To Overcome Autophagy Resistance In Castration Resistant Prostate Cancer (CRPC)

Description of Research Study: The purpose of this study is to find out how well the drug enzalutamide works in combination with metformin against your CRPC. We also want to find out which is the best dose of metformin in combination with enzalutamide for treating CRPC. Additionally, we want to find out more information about the side effects of combining enzalutamide and metformin since this is an investigational combination.
Principal Investigator: Christopher P. Evans, M.D., F.A.C.S., Department of Urologic Surgery
Co-Investigator: Primo Lara, M.D., Department of Internal Medicine, Division of Hematology Oncology
Research Coordinator: Daniel Robles, UC Davis Comprehensive Cancer Center

EMBARK, MCV3100-13, A Phase 3, Randomized, Efficacy and Safety Study of Enzalutamide Plus Leuprolide, Enzalutamide Monotherapy, and Placebo Plus Leuprolide in Men With High-Risk Nonmetastatic Prostate Cancer Progressing After Definitive Therapy

Description of Research Study: This study is also being done to test the safety of enzalutamide by itself and together with leuprolide, meaning how taking these drugs may affect your health (includes looking for possible side effects). The effects on your quality of life will also be tested.
Principal Investigator: Christopher P. Evans, M.D., F.A.C.S., Department of Urologic Surgery
Co-Investigator: Primo Lara, M.D., Department of Internal Medicine, Division of Hematology Oncology
Research Coordinator: Daniel Robles, UC Davis Comprehensive Cancer Center

Criterion-Related Validity of The Wisconsin Stone-QOL: Evaluating Evidence for Generalizability and Predictive Value

Description of Research Study: The purpose of this study is to evaluate criterion-related validity of a newly-developed disease-specific instrument to assess the health-related quality of life (HRQOL) of patients who have had kidney stones.
Principal Investigator: Noah Canvasser, M.D., Department of Urologic Surgery
Research Coordinator: Anjali Vij, Department of Urologic Surgery

Evaluation of pain before and after removal of non-obstructing renal calculi (PNORC)

Description of Research Study: The purpose of this study is to prospectively determine if the removal of non-obstructing renal calculi can reduce or eliminate participant’s pain and/or improve their quality of life through the use of questionnaires. 
Principal Investigator: Noah Canvasser, M.D.,Department of Urologic Surgery
Research Coordinator: Anjali Vij, Department of Urologic Surgery

A Study of Intravesical Bacillus Calmette-Guerin (BCG) in Combination with ALT-803 in Patients with Non-Muscle Invasive Bladder Cancer (NMIBC)

Description of Research Study: The purpose of this research study is to test the effectiveness of the combination treatment, ALT-803, plus BCG compared to treatment with BCG alone, in patients with BCG Naive NMIBC.
Principal Investigator: Marc Dall'Era, M.D., Department of Urologic Surgery
Co-Investigator: Christopher P. Evans, M.D., F.A.C.S., Department of Urologic Surgery
Research Coordinator: Anjali Vij, Department of Urologic Surgery

Prospective Validation of Prostate Biomarkers for Repeat Biopsy (PRIORITY Study)

Description of Research Study: This study is being conducted to evaluate the performance of the ConfirmMDx test for Prostate Cancer, and the SelectMDx test for Prostate Cancer to identify patients with increased risk for clinical significant disease, and to lower the rate of repeat biopsies.
Principal Investigator: Marc Dall'Era, M.D., Department of Urologic Surgery
Co-Investigator: Christopher P. Evans, M.D., F.A.C.S., Department of Urologic Surgery
Research Coordinator: Anjali Vij, Department of Urologic Surgery

UC - Davis GenitoUrinary (GU) Biospecimen Collections (Tissue, Blood and Urine)

Description of Research Study: Collection of biological specimens would consist of left-over surgical or biopsy tissue, blood or urine. These biological specimens will be collected, processed and/or stored in a research-only tissue bank for future research studies.
Principal Investigator: Marc Dall'Era, M.D., Department of Urologic Surgery
Co-Investigator: Christopher P. Evans, M.D., F.A.C.S., Department of Urologic Surgery
Research Coordinator: Anjali Vij, Department of Urologic Surgery

Stent Compared to Stentless Ureteroscopy for Renal Stones: A Pragmatic Multi-Center Randomized Trial from the Core Group

Description of Research Study: The purpose of this study is to determine if there is a difference in complications among patients undergoing ureteroscopy for renal stones who receive a stent compared to not receiving a stent postoperatively.
Principal Investigator: Noah Canvasser, M.D., Department of Urologic Surgery
Research Coordinator: Anjali Vij, Department of Urologic Surgery

Ultrasound-guided Suprapubic Catheter Training Model – Improving Patient Safety at Minimal Cost

Description of Research Study: The purpose of this study is to develop a cost effective simulator to train Residents on suprapubic catheter placement.
Principal Investigator: Jennifer Yang, M.D., Department of Urologic Surgery
Co-Investigator: Roland Palvolgyi, M.D., Department of Urologic Surgery
Research Coordinator: Anjali Vij, Department of Urologic Surgery