Su Hao Lo, PhD
Professor
Biochemistry and Molecular Medicine (SOM)
UC Davis Medical Center Research I Room 3002
(916) 734-3656
shlo@ucdavis.edu
Ph.D. - Harvard University - Cell and Developmental Biology - 1993
BS - National Taiwan University - 1986
Research interests
Cell-cell and cell-matrix junctions, focal adhesions, cytoskeleton, signal transduction, tensin, animal models for human diseases.
Graduate group affiliations
- Biochemistry, Molecular, Cellular and Developmental Biology
- Pharmacology and Toxicology
- Comparative Pathology
Recent publications
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Y Lin, N-T Chen, Y-P Shih, Y-C Liao, L Xue and SH Lo
DLC2 modulates angiogenic responses in vascular endothelial cells by regulating cell attachment and migration
Oncogene (2010) 29, 3010-3016
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Zhaoju Wu, Pei-Ching Chang, Joy C. Yang, Cheng-Ying Chu, Ling-Yu Wang, Nien-Tsu Chen, Ai-Hong Ma, Sonal J. Desai, Su Hao Lo, Christopher P. Evans, Kit S. Lam and Hsing-Jien Kung
Autophagy Blockade Sensitizes Prostate Cancer Cells towards Src Family Kinase Inhibitors
Genes & Cancer 2010 1: 40
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Valentin Lulevich, Yi-Ping Shih, Su Hao Lo, Gang-yu Liu
Cell Tracing Dyes Significantly Change Single Cell Mechanics
J. Phys. Chem. B 2009, 113, 6511–6519
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Yi-Chun Liao, Nien-Tsu Chen, Yi-Ping Shih, Ying Dong, Su Hao Lo
Up-regulation of C-Terminal Tensin-like Molecule Promotes the Tumorigenicity of Colon Cancer through B-Catenin
Cancer Res 2009; 69: (11). June 1, 2009
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Shu-Chen Hsieh, Nien-Tsu Chen, Su Hao Lo
Conditional Loss of PTEN Leads to Skeletal Abnormalities and Lipoma Formation
Mol Carcinog 48:545–552 (2009)
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Yi-Chun Liao, Yi-Ping Shih, and Su Hao Lo
Mutations in the Focal Adhesion Targeting Region of Deleted in Liver Cancer-1 Attenuate Their Expression and Function
Cancer Res 2008;68:(19). October 1, 2008
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Menachem Katz, Ido Amit, Ami Citri, Tal Shay, Silvia Carvalho, Sara Lavi, Fernanda Milanezi, Ljuba Lyass, Ninette Amariglio, Jasmine Jacob-Hirsch, Nir Ben-Chetrit, Gabi Tarcic, Moshit Lindzen, Roi Avraham,Yi-Chun Liao, Patricia Trusk, Asya Lyass, Gideon Rechavi, Neil L. Spector, Su Hao Lo, Fernando Schmitt, Sarah S. Bacus, Yosef Yarden
A reciprocal tensin-3-cten switch mediates EGF -driven mammary cell migration
Nat Cell Biol. 2007, Vol 9, 961-974
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Yi-Chun Liao, Su Hao Lo
Deleted in liver cancer-1 (DLC-1): A tumor suppressor not just for liver
J Biocel. 2007
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Yi-Chun Liao, Lizhen Si, Ralph W. deVere White, Su Hao Lo
The phosphotyrosine-independent interaction of DLC-1 and the SH2 domain of cten regulates focal adhesion localization and growth suppression activity of DLC-1
J Cell Biol. 2007, Vol 176, 43-49
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You, Z., Shi, X. B., DuRaine, G., Haudenschild, D., Tepper, C. G., Lo, S. H., Gandour-Edwards, R., deVere While, R., Reddi, A. H.
Interleukin-17 receptor-like gene is a novel anti-apoptotic gene highly expressed in androgen independent prostate cancer
Cancer Res. 2006, 66:175-183
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Lo, S. S., Lo, S. H., and Lo, S. H.
Cleavage of cten by caspase 3 during apoptosis
Oncogene. 2005, 24:4311-4314
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Cui, Y., Liao, Y. C., and Lo, S. H.
Epidermal growth factor modulates tyrosine phosphorylation of a novel tensin family member, tensin3
Molecular Cancer Research 2004 Apr;2(4):225-32.
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Chen H, Lo SH.
Regulation of tensin-promoted cell migration by its focal adhesion binding and Src homology domain 2.
Biochem J. 2003 Mar 15;370(Pt 3):1039-45.
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Lo SH, Lo TB.
Cten, a COOH-terminal tensin-like protein with prostate restricted expression, is down-regulated in prostate cancer.
Cancer Res. 2002 Aug 1;62(15):4217-21.
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Chen H, Duncan IC, Bozorgchami H, Lo SH.
Tensin1 and a previously undocumented family member, tensin2, positively regulate cell migration.
Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):733-8.
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Vinall RL, Lo SH, Reddi AH.
Regulation of articular chondrocyte phenotype by bone morphogenetic protein 7, interleukin 1, and cellular context is dependent on the cytoskeleton.
Exp Cell Res. 2002 Jan 1;272(1):32-44.
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Ishii A, Lo SH.
A role of tensin in skeletal-muscle regeneration.
Biochem J. 2001 Jun 15;356(Pt 3):737-45.
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Chen H, Ishii A, Wong WK, Chen LB, Lo SH.
Molecular characterization of human tensin.
Biochem J. 2000 Oct 15;351 Pt 2:403-11.
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Tikoo A, Cutler H, Lo SH, Chen LB, Maruta H.
Treatment of Ras-induced cancers by the F-actin cappers tensin and chaetoglobosin K, in combination with the caspase-1 inhibitor N1445.
Cancer J Sci Am. 1999 Sep-Oct;5(5):293-300.