Dominik Haudenschild, Ph.D. View profile as PDF

Name

Clinical/Research Interests

We study early responses to joint injury to learn about the pathogenesis of osteoarthritis and to identify intervention strategies.  We study chondrocyte mechanobiology to understand how mechanical forces are translated into biochemical responses.  We study cartilage matricellular proteins to gain insight into how cells interact with growth factors and the extracellular matrix.

We use animal models of joint injury and bone formation, explant models of osteochondral injuries,  stem-cell based tissue engineering, and 3-axis bioreactors to mechanically stimulate hydrogel-embedded chondrocytes and stem cells.

We apply the knowledge to translational studies. Example: Intervene with inflammatory gene expression upon joint injury to prevent or delay OA. Example: Enhance BMP-mediated bone regeneration by presenting the growth factor in a biologically relevant context on matricellular proteins.

Title:

Associate Professor, Department of Orhopaedic Surgery
 

Specilties/Focus:

Biochemistry, Molecular, Cellular and Developmental Biology
Signal Transduction and Gene Regulation

Education:

BA in Biology, Boston University, 1989
Biotech Research at Genzyme
PhD in Biochemistry and Molecular Biology, UC Davis, 2003

Professional Memberships:

Orthopaedic Research Society
International Cartilage Repair Society
OsteoArthritis Research Society International
American Society for Bone and Mineral Research 

Honors and Awards:

Arthritis Foundation
Department of Defense
NIH NIAMS R03
NIH NIAMS R21
Orthopaedic Trauma Association
Orthopaedic Research and Education Foundation

Select Recent Publications:

2014 High abundant protein removal from rodent blood for biomarker discovery, BBRC
2014 "In Vivo Fluorescence Reflectance Imaging of Protease Activity in a Mouse Model of Post-Traumatic Osteoarthritis." Osteoarthritis & Cartilage
2014 "Cartilage Oligomeric Matrix Protein and its Binding Partners in the Cartilage Extracellular Matrix: Interaction, Regulation and Role in Chondrogenesis." Matrix Biol.
2014 "Cyclin-Dependent Kinase 9 inhibition protects cartilage from the catabolic effects of pro-inflammatory cytokines." Arthritis Rheumatol.
2014 "Comparison of loading rate-dependent injury modes in a murine model of post-traumatic osteoarthritis." Journal of Orthopaedic Research
2014 "The Effect of Noggin Interference in a Rabbit Posterolateral Spinal Fusion Model." European Spine Journal
2013 "The oncogene leukemia/lymphoma-related factor (LRF) stimulates proliferation of mesenchymal stem cells and inhibits their chondrogenic differentiation." Cartilage, 4(4): 329-338.
2013 "Effect of age and cytoskeletal elements on the indentation-dependent mechanical stiffness of chondrocytes." PLoS ONE
2013 "Cartilage Oligomeric Matrix Protein Enhances Osteogenesis by Directly Binding and Activating Bone Morphogenetic Protein-2." Bone
2013 "Interactions Between FGF21 and BMP-2 in Osteogenesis." Biochemical and Biophysical Research Communications
2013 "c-Maf Transcription Factor Regulates ADAMTS-12 Expression in Human Chondrocytes." Cartilage
2012 Musculoskeletal changes following non-invasive knee injury using a novel mouse model of post-traumatic osteoarthritis." Osteoarthritis & Cartilage, PMID: 22531459.
2012 "Identification of a 3Kbp Mechanoresponsive Promoter Region in the Human Cartilage Oligomeric Matrix Protein Gene." Tissue Engineering Part A, PMID:22764748.
2012 "The Oncogene LRF is a Survival Factor in Chondrosarcoma and Contributes to Tumor Malignancy and Drug Resistance." Carcinogenesis. PMID:22847180
2012 "Chondrogenic Potential and Homogeneity of Cell Populations of Donor and Recipient Cells in a Fresh Osteochondral Allograft: A Case Report." Haudenschild DR, Hong E, Hatcher SL, and A.A. Jamali. Journal of Bone and Joint Surgery
2011 "Enhanced Activity of TGF-ß1 Bound to Cartilage Oligomeric Matrix Protein." Li H, Haudenschild DR, Di Cesare PE, Posey K, Hecht J, and Yik JHN. Journal of Biological Chemistry
2011 "Comparative Analysis with Collagen Type II Distinguioshes Cartilage Oligomeric Matrix Protein as a Primary TGF-ß-Responsive Gene." Osteoarthritis Cartilage.
2011 "Vimentin contributes to changes in chondrocyte stiffness in osteoarthritis." Haudenschild DR, Chen J, Pang N, Steklov N, Grogan SP, Lotz MK, D'Lima DD. Journal of Orthopaedic Research
2011 "Role of c-Maf in Chondrocyte Differentiation: A Review." Eunmee Hong, Paul E. Di Cesare, and Dominik R. Haudenschild. Cartilage
2010 "Rho Kinase-Dependent Activation of SOX9 in Chondrocytes", Arthritis & Rheumatism
2009 "Characterization of the Chondrocyte Actin Cytoskeleton in Living Three-Dimensional Culture: Response to Anabolic and Catabolic Stimuli" Molecular Cellular Biomechanics
2008 Rho Kinase-Dependent CCL20 Induced by Dynamic Compression of Human Chondrocytes." Arthritis & Rheumatism
2008 "Dynamic Compression of Chondrocytes Induces a Rho Kinase-Dependent Reorganization of the Actin Cytoskeleton." Biorheology.
2008 "Immunolocalization of IL-17A, IL-17B, and Their Receptors in Chondrocytes During Fracture Healing" Journal of Histochemistry & Cytochemistry
2006 "Interleukin-17 Receptor-Like Gene is a Novel Anti-apoptotic Gene Highly Expressed in Androgen-Independent Prostate Cancer" Cancer Research
2006 "Generation of Interleukin-17 Receptor-Like Protein (IL-17RL) in Prostate by Alternative Splicing of RNA" The Prostate
2006 "Bone Morphogenetic PRotein (BMP)-6 Signaling and BMP Antagonist Noggin in Prostate Cancer". Cancer Research
2003 "Interleukin-17 Family and IL-17 Receptors." Cytokine & Growth Factor Reviews
2002 "Soluble and Transmembrane Isoforms of Novel Interleukin-17 Receptor-like Protein by RNA splicing and Expression in Prostate Cancer". Journal of Biological Chemistry
2001 "Differential Expression of Multiple Genes During Articular Chondrocyte Redifferentiation". Anatomical Record
2000 "BMP Family" Review
1998 "Expression of a Stable Articular Cartilage Phenotype without Evidence of Hypertrophy by Adult Human Articular Chondrocytes in Vitro." Journal of Orthopaedic Research
1996 Cartilage Matrix Protein: Expression Patterns in Chicken, Mouse, and Human." Annals New York Academy of Sciences
1995 The Role of Coiled-Coil alpha-Helices and Disulfide Bonds in the Assembly and Stabilization of Cartilage Matrix Protein Subunits: A mutational Analysis." Journal of Biological Chemistry
1995 "Progression and Recapitulation of the Chondrocyte Differentiation Program: Cartilage Matrix Protein is a Marker for Cartilage Maturation." Developmental Biology
1995 "Cartilage Matrix Protein Forms a Type II Collagen-independent Filamentous Network: Analysis in Primary Cell Cultures with a Retrovirus Expression System." Molecular Biology of the Cell
1994 "Link Protein is Ubiquitously Expressed in Non-cartilagenous Tissues Where it Enhances and Stabilizes the Interaction of Proteoglycans with Hyaluronic Acid." Journal of Biological Chemistry


To see if  Dominik Haudenschild is accepting new patients, or for assistance finding a UC Davis doctor, please call 800-2-UCDAVIS (800-282-3284).