Peter Cala, Ph.D.

Professor Emeritus

Research Interests

  • Electroneutral Ion Transport: Na/H and K/H Exchange
  • NHE1 Structure Function Relationships
  • Hypoxic and Ischemic Cytotoxicity
  • Cell Volume and pH Regulation
  • Membranes and Transport
  • Red blood cells
  • Tumor Growth and Proliferation

Society Affiliations

  • American Physiological Society
  • Society of General Physiologists
  • Association of Chairs of Physiology Departments
  • Mount Desert Island Biological Laboratory

Graduate Group Affiliations

Nygaard, EB, Lagerstedt, JO, Bjerre, G, Shi, B, Budamagunta, M, Poulsen, KA, Meinild, S, Rigor, RR, Voss, JC, Cala, PM, Pedersen, SF. Structural modeling and electron paramagnetic resonance spectroscopy of the human Na+/H+ exchanger isoform 1, NHE1. J Biol Chem 2011 Jan 7;286: 634-48. PMCID 3013023

Ortiz-Acevedo A, Rigor III R. R, Maldonado H. M, Cala P.M. Coordinated control of volume regulatory Na+/H+ and K+/H+ exchange pathways in Amphiuma red blood cells. Am J Physiol Cell Physiol 2010 Mar;298(3):C510-20.

Ortiz-Acevedo A, Rigor III RR, Maldonado HM, Cala PM. Activation of 2 Na +/H+ and K+/H+ Exchange by Calyculin A in Amphiuma tridactylum Red Blood Cells; implications for the control of volume-induced ion flux activity. Am J Physiol Cell Physiol, 2008 Nov;284: C-1123-32.

King, S. A., E.B. Nygaard , R.R. Rigor R.R, S. F. Pedersen, and P. M. Cala. NHE1 inhibition by amiloride- and benzoyl guanidine-type compounds: inhibitor binding loci deduced from chimeras of NHE1 homologues with endogenous differences in inhibitor sensitivity. J Biol Chem. 2007 Jul 6;282(27): 19716-27. Epub 2007 May 10.

Anderson, S.E., D. M. Kirkland, A. Beyschau, and P.M. Cala. Acute effects of 17ß-estradiol on pH, Na, and Ca and ischemia/reperfusion injury. Am J. Physiol: Cell Physiol. 2005 Jan;288: C57-C64.

Stine F. Pedersen, Scott A. King, Robert R. Rigor, Zhenpeng Zhuang, Jaimie M. Warren, and Peter M. Cala. Molecular cloning of NHE1 from winter flounder RBCs: activation by osmotic shrinkage, cAMP, and calyculin A. Am J Physiol Cell Physiol 2003 Jun;284: C1561-C1576.

McLean LA, J. Roscoe, N. K. Jorgensen, F. A. Gorin, and P. M. Cala. Malignant gliomas display altered pH regulation by NHE1 compared with nontransformed astrocytes. American Journal of Physiology 2000 Apr;278: (Cell Physiol. 47) C676-C688.

McLean, LA, S. Zia, F. A. Gorin, and P. M. Cala. Cloning and expression of the Na+exchanger from Amphiuma RBCs: resemblance to mammalian NHE1. American Journal of Physiology 1999 May;276 (Cell Physiol. 45): C1025-C1037.

Anderson, S.E., E. Murphy, C. Steenbergen, R.E. London, and P.M. Cala. Na-H exchange in myocardium: effects of hypoxia and acidification on Na and Ca. American Journal of Physiology 1990 Dec;259 (Cell Physiol. 28):C940-C948.

Cala, Peter M. Volume regulation by Amphiuma red blood cells: The role of Ca+2 as a modulator of the alkali metal/proton exchanger. Journal of General Physiology 1983 Dec;82:761-784.

Cala, Peter M. Volume regulation by red blood cells: Mechanisms of ion transport. Molecular Physiology 1983;4:33-52.

Cala, Peter M. Volume regulation by Amphiuma red blood cells: The membrane potential and its implications regarding the nature of the ion flux pathways. Journal of General Physiology 1980 Dec;76:683-708.

Cala, Peter M. Volume regulation by flounder red blood cells in anisotonic media. Journal of General Physiology 1977 May;69:537-552.

  • HPH100, Special Study-Physiology
  • MCP210, Advanced Physiology
  • HPH400, Human Physiology
  • SUR493C/HPH493, Care of the Critically Ill Surgical Patient
  • National Institute of Health Merit Award
  • President, Association of Chairs of Physiology Departments
  • Past President, Association of Chairs of Physiology Departments