Job Opportunities

Recruitment Period

Open Date: November 25, 2024

Next Review Date: December 10, 2024 - Apply by December 10, 2024 (11:59 p.m.) to be considered in the first round of applicants. All applicants received will be released to the Search Committee the following day. More review dates will continue to be added if the position is not filled.

Description

The Department of Physiology and Membrane Biology at the University of California, Davis, School of Medicine, seeks to hire one, full time, Assistant Project Scientist in Eamonn Dickson’s lab. The Project Scientist will perform research functions in the area of cellular signaling with an emphasis on lipids and organelle communication in health and disease.

The Project Scientist makes significant and creative contributions to a research or creative project in their academic discipline. The appointee possesses the subject matter expertise and the creative energy necessary to function at a high level of competence. The appointee will participate in activities to increase, improve, or upgrade competency in the areas of neurobiology. Appointees with Project Scientist series may engage in university and public service. They do not have teaching responsibilities. Although the Project Scientist is expected to work independently under the general guidance of an academic member with an independent research program (i.e., Professor, Professional Researcher, etc.), they are not required to develop an independent research program or reputation. The Project Scientist will carry out research or creative programs with supervision by an individual in an academic title that carries with it automatic Principal status. The Project Scientist does not usually serve as a Principal Investigator but may do so by exception.

The incumbent will work under the supervision of Eamonn Dickson and work cooperatively and collegially in a diverse environment.

Major Responsibilities

1. RESEARCH (85% EFFORT)
   Research Activity (60%)
   This position requires creative contributions to and collaborative development of an active research program investigating topics relevant to the research area of lipids and organelle communication across health and disease. The primary research project is to develop and apply advance instrumentation allowing visualization and quantification of protein distribution at very high spatiotemporal resolution. The candidate will apply this novel instrumentation to the study of membrane proteins and downstream lipid signaling networks across different cell types, including neurons from genetically modified animals. The candidate will utilize super-resolution, confocal, and TIRF microscopy. The candidate will develop algorithms for the analysis of images. He/she is also expected to instruct post-doctoral fellows and graduate students how to use novel imaging instrumentation and all associated image processing and data analysis software.
   The appointee will help to determine research goals in consultation with the Principal Investigators. The Project Scientist will design specific projects, including the selection of appropriate methods and techniques. In some cases, the appointee may supervise students or technicians regarding the technical aspects of the research, including methods development, trouble-shooting problems, interpreting results and planning follow-up experiments. The appointee collaborates with scientific colleagues in multi-disciplinary projects that include components falling within the appointee’s area of expertise.
   
   Publication (15%)
   The appointee will publish research in peer-reviewed journals either independently or in collaboration with the PI or other members of the research team.
   
   Grant Acquisition (10%)
   The appointee will assist in writing proposals for funding from federal and state agencies and other funding organizations. The appointee will prepare and assist in the preparation of reports as required by granting agencies and prepare modifications of budgets and other grant components as needed.
2. PROFESSIONAL COMPETENCE AND ACTIVITY (10% EFFORT)
   The candidate will participate in professional societies and conferences appropriate to his/her specific field of neuroscience/cell biology and may serve as a reviewer of research proposals and scientific publications as appropriate. The candidate will attend lab meeting and seminars to present research results and may give oral presentations to public and professional interest groups.
3. UNIVERSITY AND PUBLIC SERVICE (5% EFFORT)
   The appointee may undertake administrative tasks relevant to the smooth running of the laboratory enterprise as appropriate.

Basic Qualifications

• Ph.D. degree in Physiology, Neurobiology, or related field
• At least 5 years of experience in lysosomal biology post terminal
• Prior experience presenting at international conferences

Preferred Qualification

• Experience in cell biology of lipids
• Experience in mass spectrometry of lipids
• Experience in super-resolution imaging
• Experience in fluorescence imaging
• Experience working on lysosomal cell biology
• Experience working with disease models

To Apply

To apply, please go to the following link: JPF06855. This position will remain open until filled.

Qualified applicants should submit

• CV with a complete list of publications
• Statement of research
• Contact information for 3-5 references

Recruitment Period

Open Date: October 17, 2024

Next Review Date: November 17, 2024 - Apply by November 17, 2024 (11:59 p.m.) to be considered in the first round of applicants. All applicants received will be released to the Search Committee the following day. More review dates will continue to be added if the position is not filled.

Final Review Date: June 30, 2025 - Applications will continue to be accepted through this date, but those received after the initial review date will only be considered if the position has not yet been filled.

Description

The Department of Physiology and Membrane Biology at the University of California, Davis, School of Medicine, seeks to hire one employee as a Junior Specialist in the Beleford lab . This position will be involved in interdisciplinary studies focusing on questions in vascular biology and molecular genetic causes of arterial, venous, and lymphatic malformations.

Major Responsibilities and Designated Areas of Expertise

The Junior Specialist has the general duties of working closely with the Principal Investigator (PI) in the planning and execution of a research projects. The junior specialist may assist in data collection, entry and quality control, study design and implementation, literature reviews and data analysis for preparation of manuscripts or conference presentations, and writing conference abstracts and manuscripts (e.g., methods and results sections, table, and figure generation) for a particular project.

The incumbent will work under the supervision of Daniah Beleford and work cooperatively and collegially in a diverse environment.

Successful candidates are expected to participate in three major categories of activities listed below:

1. RESEARCH (90% EFFORT)
   The incumbent will collaborate with other research personnel affiliated with research activities involving investigating the molecular genetic origin of vascular disease. The Junior Specialist will manage, maintain, and inventory transgenic mouse colonies including tagging, tail-snipping, and genotyping mice, crossbreeding to generate specific genetic lines, intraperitoneal and intragastric injections, and assisting with harvesting mouse tissues for analysis. Other responsibilities include establishing endothelial cell lines from harvested mouse and human tissues, inventorying frozen stocks, and maintaining these lines in culture. Molecular techniques that may be carried out by the Junior Specialist include immunocyto- and immunohistochemistry, fluorescent imaging and light microscopy, RNAScope, immunoprecipitation, Western analysis, and proximity ligation assay. The Junior Specialist is encouraged to lead at least one, possibly two independent research projects with input from the PI and opportunities for publication. The specialist is also expected to contribute to writing and reviewing manuscripts in preparation. The ideal candidate will be motivated, detail-oriented, have strong analytical and time-management skills, and be capable of working collaboratively with others.
2. PROFESSIONAL COMPETENCE AND ACTIVITY (5% EFFORT)
   The appointee is encouraged to attend department, and technical society talks and journal clubs relevant to vascular biology. The appointee may also attend up to 2 local or national conferences relevant to vascular biology. The PI will assist with applications for funding to attend conferences as needed.
3. UNIVERSITY AND PUBLIC SERVICE (5% EFFORT)
   The incumbent may be expected to provide mentorship to undergraduate research assistants that rotate through the lab. They will be expected to participate and contribute to laboratory and group meetings, and other activities, as applicable.

This recruitment is conducted at the junior rank. The resulting hire will be at the junior rank regardless of the proposed appointee’s qualifications.

A reasonable estimate for this position is $53,100 at Step 1 or $56,600 at Step 2.

Basic Qualifications

• Bachelor’s Degree in Biology, Genetics, or related field. Degree must be awarded before start date.
• Minimum one year of laboratory research experience.
• Experience with basic tissue culture, PCR, DNA gel

Preferred Qualifications

• Experience with rodent
• Prior experience with basic laboratory molecular
• Prior experience with mentoring early

To Apply:

To apply, please go to the following link: JPF06779. This position will remain open until filled.

Qualified applicants should submit

• Cover letter detailing their qualification for this position
• CV
• Unofficial Transcripts
• Contact information for 3 references

Daniah Beleford’s lab, within the Department of Physiology and Membrane Biology and the Department of Pediatrics at the University of California Davis, is recruiting for a postdoctoral scholar to participate in both basic and translational vascular biology research. Successful candidates will enjoy a supportive, diverse, and stimulating laboratory and departmental environment, filled with lots of collaboration, cutting-edge instrumentation and facilities, and a strong culture of training and mentorship.

The Beleford Lab studies underlying changes in molecular signaling that cause vascular malformations (abnormal development of blood vessels) in Hereditary Hemorrhagic Telangiectasia and other genetic vascular conditions. Hereditary Hemorrhagic Telangiectasia (HHT) is a rare Mendelian vascular condition that is characterized by arteriovenous malformations (AVMs), direct connections between arteries and veins without intervening capillary beds. It has previously been shown that single nucleotide polymorphisms within the genetic modifier PTPN14 (protein tyrosine phosphatase, nonreceptor, 14) associate with pulmonary AVMs in two large HHT cohorts. Our preliminary data suggest that the PTPN14 gene product binds and stabilizes BMP9 signaling components in endothelial cells, inhibiting ubiquitin-mediated protein turnover and promoting vascular stability. The Beleford Lab seeks to clarify the molecular interplay between PTPN14 and BMP9, TGFβ, and HIPPO signaling pathway components with the goal of understanding what causes the loss of vascular integrity in HHT and other severe vascular conditions in order to ultimately tailor targeted therapeutic interventions. Competitive applicants will be skilled in basic molecular and cell biology laboratory techniques as well as in mouse handling, crosses and care. The lab uses techniques such as DNA and protein electrophoresis, PCR, immunohisto- and cytochemistry, co-immunoprecipitation, proximity ligation assay.

Work/life Balance

UC Davis is a supportive, diverse, and collaborative community, ideally situated in the sunny Sacramento Valley between beautiful Lake Tahoe for winter skiing and summer beaches, and the San Francisco Bay Area.

Qualifications

Applicants must have a Ph.D. and/or M.D., D.O., M.B.B.S. degree and should have a demonstrated background in basic molecular and cell biology techniques as above. Additional training in basic genetics and genomics, including in the interpretation of genetic sequencing data, is helpful.

Successful applicants will be expected to stay abreast of current literature in the field, design and execute experiments, assist in the collection of data for grant applications, and to prepare their results for presentation at national and international scientific conferences and for publication in peer-reviewed journals. Successful applicants will also be expected to mentor graduate and undergraduate students, including hands-on teaching at the bench and in the vivarium. The ability to work independently with minimal supervision is also crucial.

Salary

The posted UC salary scales set the minimum pay determined by rank and/or step at appointment. See Table 23: Postdoctoral Scholar-Employee, Postdoctoral Scholar-Fellow, Postdoctoral Scholar-Paid Direct, Fiscal Year. The salary range for this position is $64,480 – $69,342. “Off-scale salaries”, i.e., a salary that is higher than the published system-wide salary at the designated rank and step, are offered when necessary to meet competitive conditions, qualifications, and experience.

To Apply

Qualified candidates should email the following items to Daniah Beleford at dbeleford@ucdavis.edu.

• CV/Biosketch
• Cover letter expressing your interest in the position
• Minimum of 3 professional references (Name and Email Address)