Eamonn Dickson, Ph.D.

Descending chronological order (Dual first authorship is denoted by *)

Kutchukian C, Vivas O, Casas M, Jones JG, Tiscione SA, Simó S, Ory DS, Dixon RE, Dickson EJ. “NPC1 regulates the distribution of phosphatidylinositol 4-kinases at Golgi and lysosomal membranes.” EMBO J. PMID: 34019311

Del Villar SG, Voelker TL, Westhoff M, Reddy GR, Spooner HC, Navedo MF, Dickson EJ, Dixon RE. “β-Adrenergic control of sarcolemmal Ca_V1.2 abundance by small GTPase Rab proteins.” PNAS. 2021. PMID: 33558236

Prada MP, Syed AU, Reddy GR, Martín-Aragón Baudel M, Flores-Tamez VA, Sasse KC, Ward SM, Sirish P, Chiamvimonvat N, Bartels P, Dickson EJ, Hell JW, Scott JD, Santana LF, Xiang YK, Navedo MF, Nieves-Cintrón M. “AKAP5 complex facilitates purinergic modulation of vascular L-type Ca²⁺ channel Ca_V1.2.” Nat Commun. PMID: 33082339

Casas M, Fadó R, Domínguez JL, Roig A, Kaku M, Chohnan S, Solé M, Unzeta M, Miñano-Molina AJ, Rodríguez-Álvarez J, Dickson EJ, Casals N. “Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking.” J Cell Biol. 2020. PMID: 32931550

Kirmiz, M., Gillies, T. E., Dickson, E. J., and J. S. Trimmer. (2019). “Neuronal ER-PM Junctions Organized by Kv2-VAP Pairing Recruit Nir Proteins and Affect Phosphoinositide Homeostasis”. J. Biol. Chem. 294:17735-17757. PMID: 31594866.

Tiscione SA, Vivas O, Ginsburg KS, Bers DM, Ory DS, Santana LF, Dixon RE, and Dickson EJ. Disease-associated mutations in Niemann-Pick type C1 alter ER calcium signaling and neuronal plasticity. Journal of Cell Biology. 2019 DOI: 10.1083/jcb.201903018

Kirmiz M, Gillies TE, Dickson EJ, and Trimmer JS. “Neuronal ER-plasma membrane junctions organized by Kv2-VAP pairing recruit Nir proteins and affect phosphoinositide homeostasis”. J Biol Chem. 2019 Oct 8. PMID: 31594866

Porter JD, Vivas O, Weaver CD, Abdulmohsen A, DiMilo E, Arnold LA, Dickson EJ, and Dockendorff C. An Anthrone-Based Kv7.2/7.3 Channel Blocker with Improved Properties for the Investigation of Psychiatric and Neuro- degenerative Disorders. Bioorganic & Medicinal Chemistry Letters. 2019 doi.org/10.1016/j.bmcl.2019.126681

Vivas O, Tiscione SA, Dixon RE, Ory DS, Dickson EJ. “Niemann-Pick Type C Disease Reveals a Link between Lysosomal Cholesterol and PtdIns(4,5)P2 That Regulates Neuronal Excitability”. Cell Reports. 2019 28;27(9):2636-2648. PMC6553496.

Dickson EJ (2019). “Recent advances in understanding phosphoinositide signaling in the nervous system”. F1000 Faculty Rev-278 12;8.  PMC6415330

Ito DW, Hannigan KI, Ghosh D, Xu B, Del Villar SG, Xiang YK, Dickson EJ, Navedo MF, Dixon RE. “β-adrenergic-mediated dynamic augmentation of sarcolemmal Ca_V 1.2 clustering and co-operativity in ventricular myocytes”. J Physiol. 2019 2019 597(8):2139-2162 PMC6462464

Dickson EJ, Hille B. “Understanding phosphoinositides: rare, dynamic, and essential membrane phospholipids” (2019). Biochem J. 2019 476(1):1-23. PMC6342281

Dixon RE, Vivas O, Hannigan KI, Dickson EJ. “Ground State Depletion Super-resolution Imaging in Mammalian Cells”. J Vis Exp. 2017 Nov 5;(129). doi: 10.3791/56239.

Dickson EJ. “Endoplasmic Reticulum-Plasma Membrane Contacts Regulate Cellular Excitability”. Adv Exp Med Biol. 2017;997:95-109. doi: 10.1007/978-981-10-4567-7_7.

Dickson EJ. “RASSF4: Regulator of plasma membrane PI(4,5)P2”. J Cell Biol. 2017 Jul 3;216(7):1879-1881. doi: 10.1083/jcb.20170604

Dickson EJ, Jensen JB, Vivas O, Kruse M, Traynor-Kaplan AE, Hille B. “Dynamic formation of ER-PM junctions presents a lipid phosphatase to regulate phosphoinositides”. J Cell Biol. 2016 Apr 11;213(1):33-48. doi: 10.1083/jcb.201508106

Traynor-Kaplan A, Kruse M, Dickson EJ, Dai G, Vivas O, Yu H, Whittington D, Hille B. “Fatty-acyl chain profiles of cellular phosphoinositides”. Biochim Biophys Acta. 2017 May;1862(5):513-522. doi: 10.1016/j.bbalip.2017.02.002. Epub 2017 Feb 9.

Dickson EJ (Corresponding author), Jensen JB, Vivas O, Kruse M, Traynor-Kaplan A, Hille B. “Rapid formation of ER-PM junctions presents a lipid phosphatase to regulate phosphoinositide metabolism”. J Cell Biol. 2016; 11;213(1):33-48

Dickson EJ (Corresponding author), Jensen JB, Hille B. “Regulation of calcium and phosphoinositides at endoplasmic reticulum–membrane junctions”. Biochem Soc Trans. 2016; 15;44(2):467-73.

Yu H, Dickson EJ, Koh DS, Hille B. Melatonin and N-acetyl melatonin are membrane-permeant hormones. J. Gen. Physiol., 2016;147(1):63-7

Hille B, Dickson EJ, Kruse M, Suh BC, Vivas O. “Phosphoinositides regulate ion channels”. Biochimica et Biophysica Acta., 2015 Jun;1851: 844-856

Dickson EJ, Jensen JB, Hille B. “Golgi and plasma membrane pools of PI(4)P contribute to plasma membrane PI(4,5)P2 and maintenance of KCNQ2/3 ion channel current”. PNAS., 2014; E2281–E2290.

Dickson EJ, Falkenburger BH, Hille B. “Quantitative properties and receptor reserve of the IP3 and calcium branch of Gq-coupled receptor signaling”. J. Gen. Physiol., 2013; May;141(5):521-35

Falkenbuger BH,* Dickson EJ,* Hille B. “Quantitative properties and receptor reserve of the DAG and PKC branch of Gq-coupled receptor signaling”. J. Gen. Physiol., 2013; May;141(5):537-55

Dickson EJ, Duman JG, Moody, MW, Chen L, Hille B. “Orai-STIM mediated Ca2+ release from secretory granules revealed by a novel Ca2+ and pH probe”. PNAS., 2012; Dec 18;109(51):E3539-48

Idevall-Hagren O, Dickson EJ, Hille B, Toomre DK, De Camilli P. “Optogenetic control of phosphoinositide metabolism”. PNAS., 2012; Aug 28;109(35): E2316-23.

Falkenburger BH, Jensen JB, Dickson EJ, Suh BC, Hille B. “Phosphoinositides: lipid regulators of membrane proteins”. J. Physiol., 2010; Sep 1; 588(Pt 17): 3179-3185.

Heredia DJ*, Dickson EJ*, Bayguinov PO, Hennig GW, Smith TK. “Colonic elongation inhibits pellet propulsion and migrating motor complexes in the murine large bowel”. J. Physiol., 2010; Aug 1; 588(Pt 15): 2919-2934

Dickson EJ, Heredia DJ, Smith TK. “Critical role of 5-HT1A, 5-HT3, and 5-HT7 receptor subtypes in the initiation, generation, and propagation of the murine colonic migrating motor complex”. Am. J. Physiol., 2010; Jul; 299(1): G144-157.

Smith TK, Dickson EJ, Heredia DJ, Hennig GW, Bayguinov PO. ”Controversies involving the role of 5-hydroxytryptamine (5-HT) in generating colonic migrating motor complexes: what is spontaneous?” Gastroenterology, 2010; Mar; 138(3): 1213-1214.

Dickson EJ, Heredia DJ, McCann CJ, Hennig GW, Smith TK. “The mechanisms underlying the generation of the colonic migrating motor complex in both wild-type and nNOS knockout mice”. Am. J. Physiol., 2010; Feb; 298(2): 222-233.

Heredia DJ,* Dickson EJ,* Bayguinov PO, Hennig GW, Smith TK. “Localized release of 5-HT by a fecal pellet regulates migrating motor complexes in murine colon”. Gastroenterology, 2009; Apr;136(4): 1328-1338.

Dickson EJ, Hennig GW, Heredia DJ, Lee HT, Bayguinov PO, Spencer NJ, Smith TK. “Polarized intrinsic neural reflexes in response to colonic elongation”. J. Physiol., 2008; Sep 1; 586(Pt 17): 4225-4240.

Smith TK, Spencer NJ, Hennig GW, Dickson EJ. “Recent advances in enteric neurobiology: mechanosensitive interneurons”. Neurogastroenterol. Motil., 2007; 19: 869–878

Smith TK, Dickson EJ, Hennig GW, Bayguinov PO, Spencer NJ. Colonic elongation activates an intrinsic reflex that underlies slow transit and accommodation. Physiological News, 2007; Number 69.

Dickson EJ, Spencer NJ, Bayguinov PO, Heredia DJ, Hennig GW, Smith TK. “An intrinsic occult reflex underlies accommodation and slow transit in the distal large bowel”. Gastroenterology, 2007; 132(5): 1912-24.

Spencer NJ*, Dickson EJ*, Hennig GW, Smith TK. “Sensory elements within the circular muscle are essential for mechanotransduction of ongoing peristaltic reflex activity in guinea-pig distal colon”. J. Physiol., 2006; 15; 576(Pt 2): 519-531.

Spencer N, Hennig GW, Dickson EJ, Smith TK. “Synchronization of enteric neuronal firing during the murine colonic MMC”. J. Physiol., 2005; 564: 829-847.

• Best presentation H.D. Patton symposium, University of Washington, 2015
• Member, Biochemical Society, 2015 - present
• Member, American Society for Cell Biology, 2014 - present
• Participant, 3-day Virtual Cell Short Course, Virtual Cell Modeling and Analysis, University of Connecticut, 2012
• Chair, Voltage-Sensitive Proteins, Biophysical Society 56^th Annual Meeting, San Diego, Ca, 2012
• Organizer, Interdisciplinary Lipid meeting, University of Washington, 2011 - present
• Best presentation H.D. Patton symposium, University of Washington, 2011
• Member, Biophysical Society, 2011 - present
• Glen E. Whiddett award for outstanding graduate student, University of Nevada, Reno, 2008
• Graduate student research grant award winner, University of Nevada, Reno, 2008
• Most outstanding international graduate student, University of Nevada, Reno, 2008
• Most outstanding international graduate student, University of Nevada, Reno, 2007
• Elected student President for Biomedical Science, Queens University, Belfast, 2004 - 2005