Jie Zheng, Ph.D.

An updated list of current publications: Google Scholar

Zhao, F., S. Wang, Y. Li, J. Wang, Y. Wang, C. Zhang, Y. Li, L. Huang, Y. Yu, B. Yu, J. Zheng, I. Pessah, Z. Cao (2021) “Surfactant cocamide monoethanolamide causes eye irritation by activating nociceptor TRPV1”, British Journal of Pharmacology, (in press)

Liu, C., R. Reese, S. Vu, L. Rougé, S. Shields, H. Chen, Y. Shi, T. Chernov-Rogan, K. Johnson, D.M.Z. Greiner, P.B. Kohli, D. Hackos, S. Kakiuchi-Kiyota, B. Brillantes, C. Tam, T. Li, J. Wang, S. Magnuson, M. Volgraf, J. Payandeh, J. Zheng, A. Rohou and J. Chen (2021) “A non-covalent ligand reveals biased agonism at the TRPA1 ion channel”, Neuron, 109(2):273-284.e4. doi: 10.1016/j.neuron.2020.10.014.

Vu, S., V. Singh, H. Wulff, V. Yarov-Yarovoy, J. Zheng (2020) “New capsaicin analogs as molecular rulers to define the permissive conformation of the mouse TRPV1 ligand-binding pocket”, eLife, 9:e62039. DOI: https://doi.org/10.7554/eLife.62039

Yang, F.¶, L. Xu, B.H. Lee, X. Xiao, V. Yarov-Yarovoy, J. Zheng¶ (2020) “An unorthodox mechanism underlying voltage sensitivity of TRPV1 ion channel”, Advanced Science, 2000575. DOI: 10.1002/advs.202000575

Du, G., Y. Tian, Z. Yao, S. Vu, J. Zheng, L. Chai, K. Wang, S. Yang (2020) “A specialized pore turret in the mammalian cation channel TRPV1 is responsible for distinct and species-specific heat activation thresholds”, Journal of Biological Chemistry, 295(28):9641-9649; DOI: 10.1074/jbc.RA120.013037

Zhu, A., A. Aierken, Z. Yao, S. Vu, Y. Tian¶, J. Zheng¶, S. Yang¶, F. Yang¶ (2020) “A centipede toxin causes rapid desensitization of nociceptor TRPV1 ion channel”, Toxicon, 178:41-49; DOI:10.1016/j.toxicon.2020.02.016

Yao, Z., P.M. Kamau, Y. Han, J. Hu, A. Luo, L. Luo¶, J. Zheng¶, Y. Tian¶, R. Lai¶ (2019) “The Latoia consocia caterpillar induces pain by targeting nociceptive ion channel TRPV1”, Toxins, 11: 695; DOI:10.3390/toxins11120695
6. Dong, Y., Y. Yin, S. Vu, F. Yang, V. Yarov-Yarovoy, Y. Tian¶, J. Zheng¶ (2019) “A distinct structural mechanism underlies TRPV1 activation by piperine”, Biochemical and Biophysical Research Communications, 516: 365-372 DOI: 10.1016/j.bbrc.2019.06.039

Yin, Y., Y. Dong, S. Vu, F. Yang, V. Yarov-Yarovoy, Y. Tian¶, J. Zheng¶ (2019) Structural Mechanism Underlying TRPV1 Activation by Pungent Compounds in Gingers, British Journal of Pharmacology, 176: 3364–3377. DOI: 10.1111/bph.14766

Luo, L., Y. Wang, B. Li, L. Xu, P.M. Kamau, J. Zheng¶, F. Yang¶, S. Yang¶, R. Lai¶ (2019) “Molecular Basis for Heat Desensitization of TRPV1 Ion Channels”, Nature Communications, 10:2134 (¶ corresponding authors)

Wang, H., Z. Xu, B.H. Lee, S. Vu, L. Hu, M. Lee, D. Bu, X. Cao, S. Hwang, Y. Yang, J. Zheng¶, Z. Lin¶ (2018) “Gain-of-function mutations in TRPM4 activation gate cause progressive symmetric erythrokeratoderma”, Journal of Investigative Dermatology, 139:1089-1097 (¶ corresponding authors)

Yang, F., X. Xiao, B.H. Lee, S. Vu, W. Yang, V. Yarov-Yarovoy, J. Zheng (2018) “The conformational wave in capsaicin activation of transient receptor potential vanilloid 1 ion channel”, Nature Communications,9:2879 | DOI: 10.1038/s41467-018-05339-6

Han, Y., B. Li, T. Yin, C. Xu, R. Ombati, L. Luo, Y. Xia, L. Xu, J. Zheng, Y. Zhang, F. Yang, G. Wang, S. Yang, R. Lai (2018) “Molecular mechanism of tree shrew’s insensitivity to pungency”, PLoS Biology, 16(7): e2004921.

Yang, S., F. Yang, B. Zhang, B.H. Lee, B. Li, L. Luo, J. Zheng^¶, and R. Lai^¶ (2017) “A novel bi-modal activation mechanism underlies scorpion toxin induced pain”, Science Advances, 3: e1700810 (¶ corresponding authors)

*** The paper by Yang, S., F. Yang, et al.(2017) is highlighted by Discover Magazine.

Yang, F., and J. Zheng (2017) “Understand spiciness: mechanism of TRPV1 channel activation by capsaicin”, Protein & Cell, 8(3):169-177

He, X. C. Shen, Q. Lu, J. Li, Y. Wei, L. He, R. Bai, J. Zheng, N. Luan, Z. Zhang, M. Rong, R. Lai (2016) “Prokineticin 2 Plays a Pivotal Role in Psoriasis”, EBioMedicine,  DOI: 10.1016/j.ebiom.2016.10.022

Ma, L., F. Yang, S. Vu, and J. Zheng (2016) “Exploring functional roles of TRPV1 intracellular domains with unstructured peptide-insertion screening”, Scientific Reports, 6:33827, DOI: 10.1038/srep33827

Kim, S., D. Barry, X.Y. Liu, S. Yin, A. Munanairi, Q.T. Meng, W. Cheng, P. Mo, L. Wan, S.B. Liu, K. Ratnayake, Z. Q. Zhao, N. Gautam, J. Zheng, W.K.A. Karunarathne, and Z. F. Chen (2016) “Facilitation of TRPV4 by TRPV1 is required for itch transmission in some sensory neuron populations”, Science Signaling, 9(437): ra71

Yang, F., S. Vu, V. Yarov-Yarovoy, and J. Zheng (2016) “Rational design and validation of a vanilloid-sensitive TRPV2 ion channel”, Proceedings of the National Academy of Sciences, USA, E3657–E3666

Simonov, A.N., J.K. Holien, J.C.I. Yeung, A.D. Nguyen, C.J. Corbin, J. Zheng, V.L. Kuznetsov, R.J. Auchus, A.J. Conley, A.M. Bond, M.W. Parker, R.J. Rodgers, L.L. Martin (2015) “Mechanistic scrutiny identifies a kinetic role for cytochrome b5 regulation of human cytochrome P450c17”, PLoS One, 10(11): e0141252

Yang, S., F. Yang, N. Wei, J. Hong, B. Li, L. Luo, M. Rong, V. Yarov-Yarovoy, J. Zheng¶, K.W. Wang¶, R. Lai¶ (2015) “A pain-inducing centipede toxin targets the heat activation machinery of nociceptor TRPV1”, Nature Communication, 6:8297 (¶ corresponding authors)

Lee, B.H., and J. Zheng (2015) “Proton block of proton-activated TRPV1 current”, Journal of General Physiology, 146(2):147-159

Yang, F., X. Xiao, W. Cheng, W. Yang, P. Yu, Z. Song, V. Yarov-Yarovoy, J. Zheng (2015), “Structural mechanism underlying capsaicin binding and activation of nociceptive TRPV1 ion channel”, Nature Chemical Biology, 11:518–524.

“” Jie Zheng and Matthew C. Trudeau (editors), (2015) “Handbook of Ion Channels”, CRC Press.

** Review by Richard Aldrich (2015) A new standard: a review of Handbook of Ion Channels, Journal of General Physiology, 146(2):119-121a,
** Review by David R. Harder (2015) Physiologist, 58(4):205-208
** Review by Bingcai Guan, Zuan Zhou, Hailin Zhang (2015) Acta Physiologica Sinica, 67(5)

Clifton, H.L., B. Inceoglu, L. Ma, J. Zheng, S. Schaefer (2015) “TRPV1 Channels are Involved in Niacin-induced Cutaneous Vasodilation in Mice”, Journal of Cardiovascular Pharmacology, 65(2):184-191

Ma, L., B.H. Lee, H. Clifton, S. Schaefer, and Jie Zheng (2015) “Nicotinic acid is a common regulator of heat-sensing TRPV1-4 ion channels”, Scientific Reports, 5:8906; DOI:10.1038/srep08906

Zheng, J., X. Zeng, and S. Wang (2015) “Calcium as cellular messenger”, Science China Life Sciences, 58(1):1-5

Zheng, J. and L. Ma (2014) “Structure and Function of the ThermoTRP Channel Pore”, in L. D. Islas, & F. Qin (Eds.), Thermal Sensors, 233-257

Tang, Y.Q., J.H. Zhou, F. Yang, J. Zheng, and K.W. Wang (2014) “The tetramerization domain potentiates Kv4 channel function by suppressing closed-state inactivation”, Biophysical Journal, 107: 1090-1104

Yang, F., and J. Zheng (2014) “High temperature sensitivity is intrinsic to voltage-gated potassium channels”, eLife, e03255.

• MCP210A, Advanced Physiology, Co-Instructor of Record
• MCP210L, Lab Rotation, Co-Instructor of Record
• PTX202, Principles of Pharmacology: Cellular and Molecular Basis of Drug Action
• HPH400, Medical Human Physiology
• MCP216, Neurophysiology
• MCP209, Seminar on Frontiers in Neurobiology
• HPH199, Special Study
• HPH299, Research
• MCP-BPH241, Membrane Biology
• BPH200B, Techniques in Biophysics

• The Grass Foundation Traveling Scientist Award. 2009