Department of Cell Biology and Human Anatomy

Jan Nolta, Ph.D.

Jan Nolta, Ph.D.

Professor
Institute for Regenerative Cures
2921 Stockton Blvd, Room 1300
Sacramento Campus
916-703-9308
janolta@ucdavis.edu

Jan A. Nolta, Ph.D., is the Director of the Stem Cell Program at University of California Davis School of Medicine and directs the Institute for Regenerative Cures and the UC Davis Gene Therapy Center. She is the Scientific Director of the large UC Davis Good Manufacturing Practice Facility, and PI of the California State Umbilical Cord Blood Collection Program. Through the California Institute for Regenerative Medicine funded Alpha Clinic the team administers FDA-approved cell and gene therapies. Dr. Nolta is helping UC Davis teams develop numerous clinical trials, with 59 stem cell and/or gene therapy clinical trials currently ongoing, and over twenty in the pipeline.

A scientist with 30 years’ experience with human Hematopoietic and Mesenchymal stem cells, CAR-T, gene therapy, and clinical trial development, Dr. Nolta has published over 200 peer-reviewed manuscripts in the stem cell field, with over 17,000 citations and an H factor of 72 and has authored 30+ book chapters. She has been Editor-in-Chief for the Journal “Stem Cells” for the past decade. In 2023 she was awarded the International Society of Cell Therapy Career Achievement Award in Cell and Gene Therapy.

Anindya Karmaker, Seongwon Jung, Imran Khan, Markhus Cabel, Nicholaus DeCuzzi, Madhura Patankar, Junjing Jia, Asuka Nishimura, Hayuma Otsuka, Kazuaki Ohara, Hiroshi Okawa, Whitney Cary, Ping Zhou, Jan Nolta, John G. Albeck, Raymond L. Rodriguez, Karen A. McDonald, Somen Nandi. "Production and characterization of basic fibroblast growth factor protein in rice suspension cultures". Biochemical Engineering Journal. March 2024

Jia, J., Wilson, W., Karmaker, A., Nishimura, A., Otsuka, H., Ohara, K., Okawa, H., McDonald, K., Nandi, S., Albeck, J.G., Rodriguez, R., Zhou, P., Nolta, J.A. "Applications of Plant-Made Fibroblast Growth Factor for Human Pluripotent Stem Cells", (2024) Stem Cells and Development, 1 February 2024. 33 (3-4), pp. 57-66.

Dave M, Dev A, Somoza RA, Zhao N, Viswanath S, Mina PR, Chirra P, Obmann VC, Mahabeleshwar GH, Menghini P, Durbin-Johnson B, Nolta J, Soto C, Osme A, Khuat LT, Murphy WJ, Caplan AI, Cominelli F. "MSCs mediate long-term efficacy in a Crohn's disease model by sustained anti-inflammatory macrophage programming via efferocytosis". NPJ Regen Med. 2024 Jan 20;9(1):6. doi: 10.1038/s41536-024-00347-1. PMID: 38245543; PMCID: PMC10799947.

Karmaker A.; Jung S.; Khan I.; Cabel M.; DeCuzzi N.; Patankar M.; Jia J.; Nishimura A.; Otsuka H.; Ohara K.; Okawa H.; Cary W.; Zhou P.; Nolta J.; Albeck J.G.; Rodriguez R.L.; McDonald K.A.; Nandi S. "Production and characterization of basic fibroblast growth factor protein in rice suspension cultures". Biochemical Engineering Journal. 203. 109174. 10.1016/j.bej.2023.109174.

Pollock K, Noritake S, Imai DM, Pastenkos G, Olson M, Cary W, Yang S, Fierro FA, White J, Graham J, Dahlenburg H, Johe K, Nolta JA. "An immune deficient mouse model for mucopolysaccharidosis IIIA (Sanfilippo syndrome)". Sci Rep. 2023 Oct 27;13(1):18439. doi: 10.1038/s41598-023-45178-0. PMID: 37891179; PMCID: PMC10611714.

Viswanathan S.; Blanc K.L.; Ciccocioppo R.; Dagher G.; Filiano A.J.; Galipeau J.; Krampera M.; Krieger L.; Lalu M.M.; Nolta J.; Rodriguez Pardo V.M.; Shi Y.; Tarte K.; Weiss D.J.; Martin I. "An International Society for Cell and Gene Therapy Mesenchymal Stromal Cells (MSC) Committee perspectives on International Standards Organization/Technical Committee 276 Biobanking Standards for bone marrow-MSCs and umbilical cord tissue–derived MSCs for research purposes". Cytotherapy. 2023. 25:8. 803-807.

Li T.; Conroy K.L.; Kim A.M.; Halmai J.; Gao K.; Moreno E.; Wang A.; Passerini A.G.; Nolta J.A.; Zhou P. "Role of MEF2C in the Endothelial Cells Derived from Human Induced Pluripotent Stem Cells". Stem Cells. 2023. 41:4. 341-353.

Sun YH, Kao HKJ, Thai PN, Smithers R, Chang CW, Pretto D, Yechikov S, Oppenheimer S, Bedolla A, Chalker BA, Ghobashy R, Nolta JA, Chan JW, Chiamvimonvat N, Lieu DK. "The sinoatrial node extracellular matrix promotes pacemaker phenotype and protects automaticity in engineered heart tissues from cyclic strain". Cell Rep. 2023 Dec 26;42(12):113505. doi: 10.1016/j.celrep.2023.113505. Epub 2023 Dec 2. PMID: 38041810; PMCID: PMC10790625.

Arzi B.; Nolta J.A.; Vapniarsky N. "The oromaxillofacial region as a model for a one-health approach in regenerative medicine". American Journal of Veterinary Research. 2022. 83:4. 291-297.

Nativ-Zeltzer N.; Kuhn M.A.; Evangelista L.; Anderson J.D.; Nolta J.A.; Farwell D.G.; Canestrari E.; Jankowski R.J.; Belafsky P.C. "Autologous Muscle-Derived Cell Therapy for Swallowing Impairment in Patients Following Treatment for Head and Neck Cancer". Laryngoscope. 2022. 132:3. 523-527.

Moll G.; Ankrum J.A.; Olson S.D.; Nolta J.A. "Improved MSC Minimal Criteria to Maximize Patient Safety: A Call to Embrace Tissue Factor and Hemocompatibility Assessment of MSC Products". Stem Cells Translational Medicine. 2022. 11:1. 2-13.

Deng P, Halmai JANM, Beitnere U, Cameron D, Martinez ML, Lee CC, Waldo JJ, Thongphanh K, Adhikari A, Copping N, Petkova SP, Lee RD, Lock S, Palomares M, O'Geen H, Carter J, Gonzalez CE, Buchanan FKB, Anderson JD, Fierro FA, Nolta JA, Tarantal AF, Silverman JL, Segal DJ, Fink KD. "An in vivo Cell-Based Delivery Platform for Zinc Finger Artificial Transcription Factors in Pre-clinical Animal Models". Front Mol Neurosci. 2022 Jan 27;14:789913. doi: 10.3389/fnmol.2021.789913. PMID: 35153670; PMCID: PMC8829036.

Li T.; Wu H.; Wang P.; Kim A.M.; Jia J.; Nolta J.A.; Zhou P. "HDACs regulate the differentiation of endothelial cells from human iPSCs". Cell Biochemistry and Function. 2022. 40:6. 589-599.

Johnson S, Hoch JS, Halabi WJ, Ko J, Nolta J, Dave M. "Mesenchymal Stem/Stromal Cell Therapy Is More Cost-Effective Than Fecal Diversion for Treatment of Perianal Crohn's Disease Fistulas". Front Immunol. 2022 Jun 17;13:859954. doi: 10.3389/fimmu.2022.859954. PMID: 35784367; PMCID: PMC9248358.

Weiss D.J.; Filiano A.; Galipeau J.; Khoury M.; Krampera M.; Lalu M.; Blanc K.L.; Nolta J.; Phinney D.G.; Rocco P.R.M.; Shi Y.; Tarte K.; Viswanathan S.; Martin I. "An International Society for Cell and Gene Therapy Mesenchymal Stromal Cells Committee editorial on overcoming limitations in clinical trials of mesenchymal stromal cell therapy for coronavirus disease-19: time for a global registry". Cytotherapy. 2022. 24:11. 1071-1073.

Hao D.; Lu L.; Song H.; Duan Y.; Chen J.; Carney R.; Li J.J.; Zhou P.; Nolta J.; Lam K.S.; Leach J.K.; Farmer D.L.; Panitch A.; Wang A. "Engineered extracellular vesicles with high collagen-binding affinity present superior in situ retention and therapeutic efficacy in tissue repair". Theranostics. 2022. 12:13. 6021-6037.

Yang H.-Y.; Fierro F.; Yoon D.J.; Gallegos A.; Osborn S.L.; Nguyen A.V.; Peavy T.R.; Ferrier W.; Talken L.; Ma B.W.; Galang K.G.; Medina Lopez A.; Fregoso D.R.; Stewart H.; Kurzrock E.A.; Soulika A.M.; Nolta J.A.; Isseroff R.R. "Combination product of dermal matrix, preconditioned human mesenchymal stem cells and timolol promotes wound healing in the porcine wound model". Journal of Biomedical Materials Research - Part B Applied Biomaterials. 2022. 110:7. 1615-1623.

Nolta JA. "Celebrating 40 Years as the Trusted Source for Stem Cell Manuscripts". Stem Cells. 2022 Mar 3;40(1):1. doi: 10.1093/stmcls/sxab021. PMID: 35511864.

Galipeau J.; Krampera M.; Leblanc K.; Nolta J.A.; Phinney D.G.; Shi Y.; Tarte K.; Viswanathan S.; Martin I. "Mesenchymal stromal cell variables influencing clinical potency: the impact of viability, fitness, route of administration and host predisposition". Cytotherapy. 2021. 23:5. 368-372.

Viswanathan S.; Ciccocioppo R.; Galipeau J.; Krampera M.; Le Blanc K.; Martin I.; Moniz K.; Nolta J.; Phinney D.G.; Shi Y.; Szczepiorkowski Z.M.; Tarte K.; Weiss D.J.; Ashford P. "Consensus International Council for Commonality in Blood Banking Automation–International Society for Cell and Gene Therapy statement on standard nomenclature abbreviations for the tissue of origin of mesenchymal stromal cells". Cytotherapy. 2021. 23:12. 1060-1063.

  • National Institutes of Health
  • California Institute for Regenerative Medicine
  • 2011  Deans award for Team Excellence
  • 2012  American Association for the Advancement of Science (AAAS) Fellows
  • 2013  Top 50 most influential global stem cell scientists, World Stem Cells Regenerative Medicine Congress
  • 2013  Deans Award for Excellence in Mentoring, University of California Davis Health
  • 2016  Honorable Recognition, UC Davis Women in Medicine in Health Sciences
  • 2017  HDSA Center of Excellence Honoree, Huntington’s Disease Society of America
  • 2017  Biomedical Research Exemplar, The Research Exemplar Project
  • 2017  Lifetime Leadership Award, Help 4 HD International
  • 2022  Chancellor’s Lifetime Achievement Award in Innovation
  • 2023  ISCT Career Achievement Award in Cell and Gene Therapy
  • BIM 272, Biomedical Engineering Graduate Course
  • BIO 186A, Stem Cell Technology and Medical Applications
  • BMB 290, Medical Applications of Stem Cell Technology
  • CLH 250, Integrating Medicine Into Basic Science
  • HON 493, Cancer as a Process Special Study Module
  • MCB/ECH 294, Current Progress in Biotechnology
  • 271/272, Tissue Engineering Class
  • Hematopoiesis 101: Scholars of the California Institute for Regenerative Medicine
  • Human Stem Cell Sorting, UC Davis Biotechnology Program Short Course on Flow Cytometry Special Summer Session
  • Howard Hughes Medical Students Special Summer Session
  • UC Davis Biotechnology Program Short Course on Flow Cytometry Special Summer Session
  • Stem Cells 101, Stem Cells in the Study and Treatment of Neurodegenerative Diseases, UCD/CSUS Bridges CIRM Stem Cell Program

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