IV antibiotics often come with more than just the antibiotic. Sodium is a significant portion of the carrier fluid in many IV ready to use (RTU) formulations or in the IV fluid diluent necessary for the administration of many intravenous antibiotics. In some cases, the amount of sodium infused can exceed 2g per a day making the treatment of many conditions, congestive heart failure to name just one, significantly more difficult to manage. Yet another reason to switch from IV to PO when it's safe to do so.