Javier E. Lopez, M.D. for UC Davis Health

Javier E. Lopez, M.D.

Associate Professor, Division of Cardiovascular Medicine

To see if Javier E. Lopez is accepting new patients, or for assistance finding a UC Davis doctor, please call 800-2-UCDAVIS (800-282-3284).



Internal Medicine

Locations and Contact

Lawrence J. Ellison Ambulatory Care Center

Cardiology Clinic Lawrence J. Ellison Ambulatory Care Center
4860 Y St. 4860 Y St.
Sacramento Sacramento, CA CA 95817 95817

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Additional Numbers

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Physician Referrals

800-4-UCDAVIS (800-482-3284)

Clinical Interests

Javier E. Lopez is interested in studying how soluble factors may regulate the transition of cardiac myocytes from regeneration during fetal growth to hypertrophic growth postnatally. It is postulated that the lack of cardiac regeneration in the postnatal heart confounds the myocyte dysfunction, cell death and tissue fibrosis that is associated with decompensated heart failure. Our global hypothesis is that by manipulating the cardiac gene program of the failing heart with soluble factors (drugs), we may augment endogenous and/or transplanted cardiac myocyte regeneration to ameliorate the progression of left and/or right ventricular failure. My laboratory focus is in studying the fundamental mechanisms of this growth transition to enhance the translational efficacy of soluble factors (drugs) and cell-based strategies (stem-cells) for cardiac regeneration in the failing heart.


Cardiovascular Medicine

Center/Program Affiliation

Cardiovascular Services

Undergraduate School

B.S., P.A.-C., Physician Assistant, George Washington University, Washington DC 1991

Medical School

M.D., Temple University School of Medicine, Philadelphia PA 1999


Internal Medicine, University of Texas, Dallas TX 2000


Internal Medicine, University of Texas, Dallas TX 2000


Internal Medicine/Clinical Fellow, UC Davis, Davis CA 2009


Internal Medicine/Research Fellow, UC Davis, Davis CA 2010


Internal Medicine/Post-doctoral Fellow, UC San Francisco, San Francisco CA 2007

Dean’s List, George Washington University, Washington DC,

Award for Academic Excellence, Metropolitan Life Foundation, NY,

Fellow of the Year Award, Internal Medicine, UC Davis, CA,

UC Davis School of Medicine Medical Student Research Forum, Second Place Poster Award for Sarma N, Shakeri TA, Aminololama-Shakeri S, López JE. “Breast Cancer Screening in Women with Severe Coronary Disease.”,

UC Davis 1st Annual Heart Research Day, First Place Basic Research Poster Award for Eliseo Tonatiuh Vazquez, David-Torres Barba, Janhavi S. Sharma, Elizabeth Cortez-Toledo, Omar De la Cruz Cabrera, Javier E. López, "Sarcolemma Genes Related To The Transverse Tubule Structure Are Mostly Not Expressed in Differentiating Human IPSC-derived Cardiomyocytes".,

Sirish P, Li N, Liu JY, Lee KS, Hwang SH, Qiu H, Zhao C, Ma SM, López JE, Hammock BD, Chiamvimonvat N. Unique mechanistic insights into the beneficial effects of soluble epoxide hydrolase inhibitors in the prevention of cardiac fibrosis. Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5618-23. doi:10.1073/pnas.1221972110. Epub 2013 Mar 14. PMID:23493561.

Watt C, Sirish P, Chiamvimonvat N, López JE: MicroRNAs as a window into cellular processes occurring soon after acute myocardial infarction. World Congress of Heart Disease. 2012. (Abstract)

López JE, Myagmar BE, Swigart PM, Montgomery MD, Haynam S, Bigos M, Rodrigo MC, Simpson PC. β-myosin heavy chain is induced by pressure overload in a minor subpopulation of smaller mouse cardiac myocytes. Circ Res. 2011 Sep 2;109(6):629-38. doi:10.1161/CIRCRESAHA.111.243410. Epub 2011 Jul 21. PMID:21778428.

Sirish P, López JE, Li N, Wong A, Timofeyev V, Young JN, Majdi M, Li RA, Chen HS, Chiamvimonvat N. MicroRNA profiling predicts a variance in the proliferative potential of cardiac progenitor cells derived from neonatal and adult murine hearts. J Mol Cell Cardiol. 2012 Jan;52(1):264-72. doi:10.1016/j.yjmcc.2011.10.012. Epub 2011 Oct 20. PMID:22062954.

Timofeyev V, Porter CA, Tuteja D, Qiu H, Li N, Tang T, Singapuri A, Han PL, Lopez JE, Hammond HK, Chiamvimonvat N. Disruption of adenylyl cyclase type V does not rescue the phenotype of cardiac-specific overexpression of Galphaq protein-induced cardiomyopathy. Am J Physiol Heart Circ Physiol. 2010 Nov;299(5):H1459-67. doi:10.1152/ajpheart.01208.2009. Epub 2010 Aug 13. PMID:20709863.

Lopez JE, Yeo K, Caputo G, Buonocore M, Schaefer S. Recovery of methamphetamine associated cardiomyopathy predicted by late gadolinium enhanced cardiovascular magnetic resonance. J Cardiovasc Magn Reson. 2009 Nov 11;11(1):46. doi:10.1186/1532-429X-11-46. PMID:19906310.

Epting CL, López JE, Pedersen A, Brown C, Spitz P, Ursell PC, Bernstein HS. Stem cell antigen-1 regulates the tempo of muscle repair through effects on proliferation of alpha7 integrin-expressing myoblasts. Exp Cell Res. 2008 Mar 10;314(5):1125-35. doi:10.1016/j.yexcr.2007.11.010. Epub 2007 Nov 19. PMID:18073129.

Lopez JE, Myagmar BE, Swigart P, Bigos M, Rodrigo M, Simpson PC. Beta-Myosin Heavy Chain induction after pressure overload is in a minor sub-population of myocytes and requires the Alpha-1A-Adrenergic Receptor. Circulation Supplement. 2007;116(II):19. (Abstract)

Epting CL, López JE, Shen X, Liu L, Bristow J, Bernstein HS. Stem cell antigen-1 is necessary for cell-cycle withdrawal and myoblast differentiation in C2C12 cells. J Cell Sci. 2004 Dec 1;117(Pt 25):6185-95. doi:10.1242/jcs.01548. Epub 2004 Nov 16. PMID:15546912.