Janine LaSalle, Ph.D.
Our laboratory is interested in the role of epigenetics in human autism-spectrum disorders. Epigenetics is the study of heritable changes in chromosomes that are not encoded in the DNA sequence, including DNA methylation and chromatin organization. The clinical applications of our research include understanding the pathogenesis of the neurodevelopmental disorders autism, Rett syndrome, Prader-Willi syndrome, Angelman syndrome, and Dup15q syndrome. We are also interested in identifying epigenetic biomarkers at the interface of genetic and environmental risk factors in autism-spectrum disorders using tissues accessible from birth, such as placenta and cord blood.
For more information, visit the LaSalle Laboratory website.
Vogel Ciernia A*, Laufer BI*, Hwang H, Dunaway KW, Mordaunt CE, Coulson RL, Yasui DH, LaSalle JM. 2019. Epigenomic convergence of genetic and immune risk factors in autism brain. Cerebral Cortex.
Laufer BI, Hwang H, Vogel Ciernia A, Mordaunt CE, LaSalle JM. 2019. Whole genome bisulfite sequencing of Down syndrome brain reveals regional DNA hypermethylation and novel disease insights. Epigenetics.
Zhu Y, Mordaunt CE, Yasui DH, Marathe R, Coulson RL, Dunaway KW, Jianu JM, Walker CK, Ozonoff S, Hertz-Picciotto I, Schmidt RJ, LaSalle JM. 2019. Placental DNA methylation levels at CYP2E1 and IRS2 are associated with child outcome in a prospective autism study. Human Molecular Genetics.
Mordaunt CE, Kieffer DA, Shibata NM, Członkowska A, Litwin T, Weiss KH, Zhu Y, Bowlus CL, Sarkar S, Cooper S, Wan YY, Ali MR, LaSalle JM, Medici V. 2019. Epigenomic signatures in liver and blood of Wilson disease patients include hypermethylation of liver-specific enhancers. Epigenetics & Chromatin.
Lopez SJ, Segal DJ, LaSalle JM. 2019. UBE3A: An E3 Ubiquitin Ligase With Genome-Wide Impact in Neurodevelopmental Disease. Frontiers in Molecular Neuroscience.
Ciernia AV, Yasui DH, Pride MC, Durbin-Johnson B, Noronha A, Chang A, Knotts T, Rutkowsky J, Ramsey JJ, Crawley JN, LaSalle JM. August 2018. MeCP2 isoform e1 mutant mice recapitulate motor and metabolic phenotypes of Rett syndrome. Human Molecular Genetics.
Coulson RL, Powell WT, Yasui DH, Dileep G, Resnick J, LaSalle JM. August 2018. Prader-Willi locus Snord116 RNA processing requires an active endogenous allele and neuron-specific splicing by Rbfox3/NeuN. Human Molecular Genetics.
Mordaunt CE, Shibata NM, Kieffer DA, Czlonkowska A, Litwin T, Weiss KH, Gotthardt DN, Olson K, Wei D, Cooper S, Wan YY, Ali M, LaSalle JM, Medici V. July 2018. Epigenetic changes of the thioredoxin system in the tx-j mouse model and in patients with Wilson disease. Human Molecular Genetics.
Adhikari A, Copping NA, Onaga B, Pride MC, Coulson RL, Yang M, Yasui DH, LaSalle JM, Silverman JL. May 2018. Cognitive deficits in the Snord116 deletion mouse model for Prader-Willi syndrome. Neurobiol Learn Mem.
Coulson R, Yasui D, Dunaway K, Laufer BI, Vogel Ciernia A, Mordaunt C, Totah T, LaSalle JM. May 2018. Snord116-dependent diurnal rhythm of DNA methylation in mouse cortex. Nature Communications.
Vogel Ciernia A*, Laufer BI*, Dunaway KW, Mordaunt CE, Coulson RL, Totah TS, Stolzenberg DS, Frahm JC, Singh-Taylor A, Baram TZ, LaSalle JM, Yasui DH. April 2018. Experience-dependent neuroplasticity of the developing hypothalamus: integrative epigenomic approaches. Epigenetics.
Vogel Ciernia A, Careaga M, LaSalle JM, Ashwood P. November 2017. Microglia from offspring of dams with allergic asthma exhibit epigenomic alterations in genes dysregulated in autism. Glia.
Lopez SJ, Dunaway K, Islam MS, Mordaunt C, Vogel Ciernia A, Meguro-Horike M, Horike S, Segal DJ, LaSalle JM. September 2017. UBE3A-mediated regulation of imprinted genes and epigenome-wide marks in human neurons. Epigenetics.
Vogel Ciernia A, Pride M, Durbin-Johnson B, Noronha A, Chang A, Yasui DH, Crawley JN, LaSalle JM. March 2017. Early motor phenotype detection in a female mouse model of Rett syndrome is improved by cross-fostering. Hum Mol Genet.
Crary-Dooley FK, Tam ME, Dunaway KW, Hertz-Picciotto I, Schmidt RJ, LaSalle JM. January 2017. A comparison of existing global DNA methylation assays to low-coverage whole-genome bisulfite sequencing for epidemiological studies. Epigenetics.
Schroeder DI, Schmidt RJ, Crary-Dooley FK, Walker CK, Ozonoff S, Tancredi DJ, Hertz-Picciotto I, LaSalle JM. December 2016. Placental methylome analysis from a prospective autism study. Mol Autism.
Dunaway K, Goorha S, Matelski L, Urraca N, Lein PJ, Korf I, Reiter LT, LaSalle JM. December 2016. Dental Pulp Stem Cells Model Early Life and Imprinted DNA Methylation Patterns. Stem Cells.
Dunaway KW, Islam MS, Coulson RL, Lopez SJ, Ciernia AV, Chu RG, Yasui DH, Pessah IN, Lott P, Mordaunt C, Meguro-Horike M, Horike S, Korf I, LaSalle JM. December 2016. Cumulative Impact of Polychlorinated Biphenyl and Large Chromosomal Duplications on DNA Methylation, Chromatin, and Expression of Autism Candidate Genes Epigenetics. Cell Rep.
Yasui DH, Peedicayil J, Grayson DR (Editors). November 2016. Neuropsychiatric Disorders and Epigenetics. Translational Epigenetics Series, Elsevier.
Medici V, Kieffer DA, Shibata NM, Chima H, Kim K, Canovas A, Medrano JF, Islas-Trejo AD, Kharbanda KK, Olson K, Su RJ, Islam MS, Syed R, Keen CL, Miller AY, Rutledge JC, Halsted CH, LaSalle JM. September 2016. Wilson Disease: Epigenetic effects of choline supplementation on phenotype and clinical course in a mouse model. Epigenetics.
Veeraragavan S, Wan YW, Connolly DR, Hamilton SM, Ward CS, Soriano S, Pitcher MR, McGraw CM, Huang SG, Green JR, Yuva LA, Liang AJ, Neul JL, Yasui DH, LaSalle JM, Liu Z, Paylor R, Samaco RC. June 2016. Loss of MeCP2 in the rat models regression, impaired sociability and transcriptional deficits of Rett syndrome. Hum Mol Genet.
Ciernia AV, LaSalle J. May 2016. The landscape of DNA methylation amid a perfect storm of autism aetiologies. Nat Rev Neurosci.
Rube HT, Lee W, Hejna M, Chen H, Yasui DH, Hess JF, LaSalle JM, Song JS, Gong Q. March 2016. Sequence features accurately predict genome-wide MeCP2 binding in vivo. Nat Commun.
Crawley JN, Heyer WD, LaSalle JM. March 2016. Autism and Cancer Share Risk Genes, Pathways, and Drug Targets. Trends Genet.
LaSalle JM, Reiter LT, Chamberlain SJ. October 2015. Epigenetic regulation of UBE3A and roles in human neurodevelopmental disorders. Epigenomics.