Richard W. Michelmore, Ph.D.
Director, Genome Center
4311 GBSF
Davis Campus

Our research is focused on the comparative and functional genomics of disease resistance in plants, particularly Arabidopsis, tomato and lettuce. Our investigations of Arabidopsis involve the large-scale genomic analysis of resistance gene function and evolution in Arabidopsis as well as a comparative genomics analysis of resistance across multiple species. Our studies of disease resistance in tomato focus on structure-function analyses on the resistance gene Pto, Prf and dissection of the Pto-mediated disease resistance signaling pathway. Studies on lettuce and its pathogens includes classical studies of disease resistance, development of detailed genetic maps using molecular markers, studies on transgene expression and characterization of resistance genes at the molecular level. All of these projects are supported by the lab bioinformatics group.

View the Lab Page »

Macias-Gonzalez M, Truco MJ, Bertier LD, Jenni S, Simko I, Hayes RJ, Michelmore RW. (2019) Genetic architecture of tipburn resistance in lettuce. Theor Appl Genet. 2019 132(8):2209-2222.

Mamo BE, Hayes RJ, Truco MJ, Puri KD, Michelmore RW, Subbarao KV, Simko I. (2019) The genetics of resistance to lettuce drop (Sclerotinia spp.) in lettuce in a recombinant inbred line population from Reine des Glaces × Eruption. Theor Appl Genet. 2019 132(8):2439-2460.

Inderbitzin P, Christopoulou M, Lavelle D, Reyes-Chin-Wo S, Michelmore RW, Subbarao KV, Simko I. (2019) The LsVe1L allele provides a molecular marker for resistance to Verticillium dahliae race 1 in lettuce. BMC Plant Biol. 2019 19(1):305.

Su W, Tao R, Liu W, Yu C, Yue Z, He S, Lavelle D, Zhang W, Zhang L, An G, Zhang Y, Hu Q, Larkin RM, Michelmore RW, Kuang H, Chen J. (2019) Characterization of four polymorphic genes controlling red leaf color in lettuce that have undergone disruptive selection since domestication. Plant Biotechnol J. 2019 Jul 20.

Fletcher K, Gil J, Bertier LD, Kenefick A, Wood KJ, Zhang L, Reyes-Chin-Wo S, Cavanaugh K, Tsuchida C, Wong J, Michelmore R. (2019) Genomic signatures of heterokaryosis in the oomycete pathogen Bremia lactucae. Nat Commun. 2019 Jun 14;10(1):2645.

Fletcher , K. Michelmore, R. (2018) From Short Reads to Chromosome-Scale Genome Assemblies. Methods Mol. Biol. 2018 1848:151-197

Wroblewski T., Spiridon, L., Martin, E.C., Petrescu, A.-J., Cavanaugh, K., Truco, M.-J., Xu, H., Gozdowski, D.,, Pawlowski, K., Michelmore, R.W., Takken, F.L.W. (2018) Genome-wide functional analyzes of plant CC-NB-LRR pathogen receptors reveal essential roles of their N-terminal domain in oligomerization, networking and immunity. PLoS Biology 2018 Dec 12;16(12):e2005821.

Li, R., Jeong, K., Davis, J.T., Kim, S., Lee, S., Michelmore, R.W., Kim, S., Maloof, J.M. (2018) Integrated QTL and eQTL mapping provides insights and candidate genes for fatty acid composition, flowering time, and growth traits in a F2 population of a novel synthetic allopolyploid Brassica napus. Frontiers in Pl. Sci. 2018 Nov 13;9:1632.

Simko, I., Hayes, R.J., Truco, M.J., Michelmore, R.W., Antonise, R., Massoudi, M. (2018) Molecular markers reliably predict post-harvest decay of fresh-cut lettuce in modified atmosphere packaging. Hort. Res. 2018 Apr 1;5:21.

Kitazaki, K., Fukushima, A., Nakabayashi, R., Okazaki, Y., M., Mori, T., Nishizawa, T., Reyes-Chin-Wo, S., Michelmore, R.W., Saito, K., Shoji, K., Kusano, M. (2018) Metabolic Reprogramming in Leaf Lettuce Grown Under Different Light Quality and Intensity Conditions Using Narrow-Band LEDs. Scientific Repts. 2018 8:7914.

Fletcher K, Klosterman SJ, Derevnina L, Martin F, Bertier LD, Koike S, Reyes-Chin-Wo S, Mou B, Michelmore R. (2018) Comparative genomics of downy mildews reveals potential adaptations to biotrophy. BMC Genomics. 2018 Nov 29;19(1):851.

Sandoya GV, Gurung S, Short DP, Subbarao KV, Michelmore RW, Hayes RW. (2017) Genetics of resistance in lettuce to races 1 and 2 of Verticillium dahliae from different host species. Euphytica 2017 213:20

Reyes-Chin-Wo, S., Wang, Z., Yang, X., Kozik, A., Arikit, S., Song, C., Xia, L., Froenicke, L., Lavelle, D.O., Truco, M-J., Xia, R., Zhu, S., Xu, C., Xu, H., Xu, X., Cox, K., Korf, I., Meyers, B.C., Michelmore, R.W. (2017) Genome assembly with in vitro proximity ligation data and whole genome triplication in lettuce. Nature Comm. 2017 8:14953.

Zhang, I., Zhang, W., Chen, J., Wu, P., Tao, R., Jia, Y., Larkin, R.M., Lavelle, D., Michelmore, R.W., Kuang, H. (2017) RNA sequencing provides insights into the evolution of lettuce and the regulation of flavonoid biosynthesis. Nature Comm. 2017 8:2264-2276.

Bertier, L.D., Ron, M., Huo, H., Bradford, K.J., Michelmore, R.W. (2017) High-resolution analysis of the efficiency, heritability, and editing outcomes of CRISPR/CAS9-induced modifications of NCED4 in lettuce (Lactuca sativa). G3, Genes, Genomes, Genetics 2017 8:1513-1521.

Michelmore, R.W., Coaker, G. et 38 al. (2017) Foundational and translational research opportunities to improve plant health. Molec. Plant-Microbe Interact. 2017 30:515-516.

Michelmore, R.W. (2017) Applications of biotechnology and genomics to disease resistance in lettuce. In: Compendium of Lettuce Diseases and Pests, Second Edition. K. V. Subbarao, ed. APS Press. 2017 pp 9 - 13.

Scaglione D, Reyes-Chin-Wo S, Acquadro A, Froenicke L, Portis E, Beitel C, Tirone M, Mauro R, Lo Monaco A, Mauromicale G, Faccioli P, Cattivelli L, Rieseberg L, Michelmore R, Lanteri S. (2016) The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny. Sci Rep. 2016 Jan 20;6:19427.

Yoong FY, O'Brien LK, Truco MJ, Huo H, Sideman R, Hayes R, Michelmore RW, Bradford KJ. (2016) Genetic Variation for Thermotolerance in Lettuce Seed Germination Is Associated with Temperature-Sensitive Regulation of ETHYLENE RESPONSE FACTOR1 (ERF1). Plant Physiol. 2016 Jan;170(1):472-88.

Scaglione D, Reyes-Chin-Wo S, Acquadro A, Froenicke L, Portis E, Beitel C, Tirone M, Mauro R, Lo Monaco A, Mauromicale G, Faccioli P, Cattivelli L, Rieseberg L, Michelmore R, Lanteri S. (2016) Corrigendum: The genome sequence of the outbreeding globe artichoke constructed de novo incorporating a phase-aware low-pass sequencing strategy of F1 progeny. Sci Rep. 2016 May 23;6:25323.

Bertioli, D J and Cannon, S B and Froenicke, L and Huang, G and Farmer, A D and Cannon, E K S and Liu, X and Gao, D and Clevenger, J and Dash, S and Ren, L and Moretzsohn, M C and Shirasawa, K and Huang, W and Vidigal, B and Abernathy, B and Chu, Y and Nie (2016) The genome sequences of Arachis duranensis and Arachis ipaensis, the diploid ancestors of cultivated peanut. Nat Genet 2016 Apr;48(4):438-46.

Parra L, Maisonneuve B, Schut J, Christopoulou M, Jeuken M, McHale L, Truco M-J, Crute I, Michelmore R (2016) Rationalization of genes for resistance to Bremia lactucae in lettuce. Euphytica 2016 210: 309-326.

Kunjeti SG, Anchieta A, Martin FN, Choi YJ, Thines M, Michelmore RW, Koike ST, Tsuchida C, Mahaffee W, Subbarao KV, Klosterman SJ. (2016) Detection and Quantification of Bremia lactucae by Spore Trapping and Quantitative PCR. Phytopathology 2016 Nov;106(11):1426-1437.

Chadwick M, Gawthrop F, Michelmore RW, Wagstaff C, Methven L. (2016) Perception of bitterness, sweetness and liking of different genotypes of lettuce. Food Chem. 2016 Apr 15;197(Pt A):66-74.

Christopoulou M, McHale L, Kozik A, Reyes-Chin Wo S, Wroblewski T, Michelmore RW. (2015) Dissection of Two Complex Clusters of Resistance Genes in Lettuce (Lactuca sativa) Mol Plant Microbe Interact. 2015 Feb 4.