George Thompson, M.D.
Professor of Medicine
Tupper Hall
Room 3134
Davis Campus
e-mail
Dr. Thompson is Professor of Clinical Medicine at the University of California, Davis, School of Medicine with a joint appointment in the Departments of Medical Microbiology and Immunology, and Internal Medicine, Division of Infectious Diseases. Dr. Thompson specializes in the care of patients with invasive fungal infections and has research interest in fungal diagnostics and host immunogenetics. His current research focuses on the host-pathogen interaction of humans and both Coccidioides spp. (the agent of “Valley Fever”), and Cryptococcus spp.
Dr. Thompson has served on the IDSA Journal Club which is a committee comprised of 12 panelists who select key papers for review and compose a summary of important articles that is published in the internationally disseminated monthly IDSA News. Additionally, he is a member of the Coccidioidomycosis Study Group Planning Committee, and as Co-chair of the Mycoses Study Group - a committee responsible for the development of content and dissemination of materials to practitioners across the United States, planning of the mycology content at our yearly meetings (IDSA and ICAAC), and the design of clinical trials.
“Selected from 86 peer-reviewed publications.”
Thompson GR III, Chang D, Wittenberg RR, McHardy I, Semrad A. Posaconazole Induced Hypertension and Hypokalemia: In vivo 11β-hydroxysteroid dehydrogenase Inhibition. Antimicrobial Agents and Chemotherapy. 2017 Jul 25;61(8).
Jiang G, Santos-Rocha C, Hirao L, Mendes E, Tang Y, Thompson GR III, Wong J, and Satya Dandekar. HIV exploits anti-viral host innate GCN2-ATF4 signaling for establishing its own replication early in infection. mBio. 2017 May 2;8(3).
Thompson GR III, Blair J, Wang S, Bercovitch R, Bolaris M, Van Den Akker D, Lopez R, Heidari A, Catanzaro A, Cadena J, Chin-Hong P, Spellberg B, Johnson R. Adjunctive Corticosteroid Therapy in the Treatment of Coccidioidal Meningitis. Clinical Infectious Diseases. 2017 Jul 15;65(2):338-341.
Thompson GR III, Barker B, Wiederhold NP. Large Scale Evaluation of in vitro Amphotericin B, Triazole, and Echinocandin activity against Coccidioides species from United States Institutions. Antimicrobial Agents and Chemotherapy. 2017 April 61(4):e02634-16; 1-4
Thompson GR III, Tuscano JM, Dennis M, Singapuri A, Libertini S, Gaudino R, Torres A, Delisle JMP, Gillece JD, Schupp JM, Engelthaler DM. A Microbiome Assessment of Medical Marijuana. Clinical Microbiology and Infection. 2017 Apr;23(4):269-270.
*Featured by New York Times, Washington Post, Sacramento Bee
*Featured by DailyMail (London)
*Featured on local, regional (KPIX) and national CBS, NPR, etc
Sykes JE, Hodge G, Gelli A, Yang ML, Thompson GR III. In vivo Development of Fluconazole Heteroresistance in Cryptococcus gattii. Medical Mycology. 2017 Jun 1;55(4):396-401.
Stewart ER, Thompson GR III. Update on the Epidemiology of Coccidioidomycosis. Current Fungal Infection Reports. 2016 Oct 10:141-146.
Stewart ER, Thompson GR III. Treatment of Primary Pulmonary Aspergillosis: An assessment of the evidence. Journal of Fungi. 2016 2(25):1-9.
Vishkautsan P, Papich MG, Thompson GR III, Sykes JE. Pharmacokinetics of voriconazole after intravenous and oral administration to healthy cats. American Journal of Veterinary Research. 2016 Sep;77(9):931-9. PMID: 27580104
Patterson TF, Thompson GR III, Denning D, Fishman F, Hadley S, Herbrecht R, Kontoyiannis DP, Marr KA, Morrison VA, Nguyen MH, Segal BH, Steinbach WJ, Stevens DA, Walsh TJ, Wingard JR, Young J, Bennett JE. Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America. Clinical Infectious Diseases. 2016 Aug 15;63(4):e1-e60. PMID: 27365388
Patterson TF, Thompson GR III, Denning D, Fishman F, Hadley S, Herbrecht R, Kontoyiannis DP, Marr KA, Morrison VA, Nguyen MH, Segal BH, Steinbach WJ, Stevens DA, Walsh TJ, Wingard JR, Young J, Bennett JE. Executive Summary: Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America. Clinical Infectious Diseases. 2016 Aug 15;63(4):433-42. PMID: 27481947
Donnelley MA, Zhu ES, Thompson GR III. Isavuconazole in the Treatment of Invasive Aspergillosis and Mucormycosis Infections. Infection and Drug Resistance. 2016 Jun 2;9:79-86. PMID: 27330318
Thompson GR III, Rendon A, Santos R, Queiroz-Telles F, Ostrosky-Zeichner L, Zeiher B, Maher R, Lee M, Kovanda L, Vazquez J, Cornely OA, Perfect JR. Isavuconazole Treatment of Cryptococcosis and Dimorphic Mycoses. Clinical Infectious Diseases. 2016 Aug 1;63(3):356-62. PMID: 27169478
*Featured in New England Journal of Medicine Journal Watch:
http://www.jwatch.org/na41872/2016/07/22/isavuconazole-cryptococcosis-and-dimorphic-fungal?query=etoc_jwid&jwd=000012379100&jspc=ID
*Featured in Faculty of 1000:
http://f1000.com/prime/726354284?subscriptioncode=d67730d8-e81c-4951-887b-b41f8f1421aa
Schwartz IS, Kenyon C, Thompson GR III. Endemic Mycoses: What’s new about old diseases? Current Clinical Microbiology Reports. 2016 3:71–80
Engelthaler DM, Roe CC, Hepp, CM, Teixeira M, Driebe EM, Schupp JM, Gade L, Waddell V, Komatsu K, Arathoon E, Logemann H, Thompson GR III, Chiller T, Barker B, Litvintseva AP, Keim P. Coccidioides whole population genome SNP analysis reveals local population structure and patterns of hemispheric dispersal. Manuscript accepted for publication to mBio. 2016 Apr 26;7(2). PMID: 27118594
Marty FM, Ostrosky-Zeichner L, Cornely OA, Mullane KM, Perfect JR, Thompson GR III, Alangaden GJ, Brown JM, Fredricks JN, Heinz WJ, Herbrecht R, Klimko N, Klyasova G, Maertens JA, Melinkeri SR, Oren I, Pappas PG, Ráčil Z, Rahav G, Santos R, Schwartz S, Vehreschild J, Young JH, Chetchotisakd P, Jaruratanasirikul S, Kanj SS, Engelhardt M, Kaufhold A, Ito M, Lee M, Sasse C, Maher R, Zeiher B, Vehreschild MJGT, for the VITAL and FungiScopeä Mucormycosis Investigators. Isavuconazole Treatment for Mucormycosis. The Lancet Infectious Disease. 2016 Jul;16(7):828-37. PMID: 26969258
Cadena J, Thompson GR III, Patterson TF. Invasive Aspergillosis: Current Strategies for Diagnosis and Management. Infectious Disease Clinics of North America. 2016 Mar;30(1):125-42. PMID: 26897064
Stockamp N, Thompson GR III. Coccidioidomycosis. Infectious Disease Clinics of North America. 2016 Mar;30(1):229-46. PMID: 26739609
Maertens JA, Raad I, Marr KA, Patterson TF, Kontoyiannis DP, Cornely OA, Bow EJ, Rahav G, Neofytos D, Aoun M, Baddley JW, Giladi M, Heinz W, Herbrecht R, Hope W, Karthaus M, Lee DG, Lortholary O, Morrison VA, Oren I, Selleslag D, Shoham S, Supparatpinyo K, Thompson GR III, Lee M, Maher R, Schmitt-Hofmann AH, Zeiher B, Ullmann AJ. Isavuconazole versus Voriconazole for Primary Treatment of Invasive Mold Disease Caused by Aspergillus and Other Filamentous Fungi (The SECURE study). Lancet. 2016 Feb 20;387(10020):760-9. PMID: 26684607
Yang ML, Uhrig J, Vu K, Singapuri A, Dennis M, Gelli A, Thompson GR III. Fluconazole Susceptibility in Cryptococcus gattii is dependent on the ATP binding cassette (ABC) Transporter PDR11. Antimicrobial Agents and Chemotherapy. 2015 Dec 7;60(3):1202-7. PMID: 26643330
Stewart E, Waldman S, Sutton DA, Sanders C, Lindner J, Fan H, Wiederhold NP, Thompson GR III. Ustilago echinata as a cause of Traumatic Osteomyelitis. Mycopathologia. 2016 Apr;181(3-4):311-4. PMID: 26590580
Benedict K, Thompson GR III, Deresinski S, Chiller T. Mycotic Infections Acquired outside Areas of Known Endemicity, United States. Emerging Infectious Diseases. 2015 Nov;21(11):1935-41. PMID: 26485441
Twarog M, Thompson GR III. Coccidioidomycosis: Recent Updates. Seminars in Respiratory and Critical Care Medicine. 2015 Oct;36(5):746-55. PMID: 26398540
Hodge G, Cohen SH, Thompson GR III. Intrathecal Therapy with Amphotericin B – potential pharmacodynamics interactions with concurrently administered hydrocortisone. Medical Mycology. 2015 Sep 1;53(7):749-53. PMID: 26162473
Jiang G, Mendes EA, Kaiser P, Tang Y, Cai I, Fenton A, Melcher GP, Hildreth JEK, Thompson GR III, Wong JK, Dandekar S. Synergistic reactivation of latent HIV expression by PEP005 targeted NF-kB signaling in combination with JQ1 induced p-TEFb production. PLoS Pathogens. 2015 Jul 30;11(7):e1005066. PMID: 26225771
*Featured by the BBC: http://www.bbc.com/news/health-33720325
Lee CY, Thompson GR III, Hastey C, Hodge GC, Lunetta JM, Pappagianis D, Heinrich V. Single-cell recognition of Coccidioides by human neutrophils and comparison with other fungi and model pathogens. PLoS One. 2015 Jun 12;10(6):e0129522. PMID: 26070210
*Featured in Faculty of 1000: http://f1000.com/prime/725550452?subscriptioncode=73335183-63cf-49e6-adf1-4f7b40202493
DeRiemer K, Thompson GR III. Lung Microbiomes – new frontiers? American Journal of Respiratory and Critical Care Medicine. 2015. Apr 15;191(8):870-1. PMID: 25876200
Thompson GR III, Stevens DA, Clemons KV, Fierer J, Johnson RH, Sykes J, Rutherford G, Peterson M, Taylor JW, Chaturvedi V. Call for a California Coccidioidomycosis Consortium to Face the Top Ten Challenges Posed by a Recalcitrant Regional Disease. Mycopathologia. 2015 Feb;179(1-2):1-9. PMID: 25318989
Espinel-Ingroff A, Chowdhary A, Gonzalez GM, Guinea J, Hagen F, Meis J, Thompson GR III, Turnidge J. Isavuconazole MIC Distributions and Epidemiological Cutoff Values for the Cryptococcus neoformans-Cryptococcus gattii complex by the CLSI Broth Microdilution Method (M27-A3 document): A Multicenter Study. Antimicrobial Agents and Chemotherapy. 2014. Epub ahead of print. PMID: 25313209
Najafi S, Aronowitz, P, Thompson GR III. The Habit Tic: onychotillomania. Journal of General Internal Medicine. 2014. 2015 Feb;30(2):264. PMID: 25300900
Eldridge M, Chambers CJ, Sharon VR, Thompson GR III. Fungal infections of the skin and nail: new treatment options. Expert Review of Anti-infective Therapy. 2014 Nov;12(11):1389-405. PMID: 25241767
Litvintseva AP, Marsden-Haug N, Hurst S, Hill H, Gade L, Engelthaler DM, Driebe E, Roe C, Keim P, Ralston C, Wohrle R, Goldoft M, Thompson GR III, Chiller T, Brandt M. Valley Fever: Finding new places for an old disease: Coccidioides immitis found in Washington State soil associated with recent human infection. Clinical Infectious Diseases. Jan 1;60(1):e1-3. PMID: 25165087
Engelthaler DM, Hicks N, Gillece J, Roe C, Schupp JM, Driebe EM, Gilgado F, Carriconde F, Trilles L, Firacative C, Ngamskulrungroj P, Castaneda E, Lazera MDS, Melhem M, Perez-Bercoff A, Huttlley G, Sorrell T, Voelz K, My RC, Fisher M, Thompson GR III, Lockhart S, Keim P, Meyer W. Cryptococcus gattii in North American Pacific Northwest: whole population genome analysis provides insights into species evolution and dispersal. mBio. 2014 Jul 15;5(4). PMID: 25028429
Vu K, Tham R, Uhrig JP, Thompson GR III, Na Pombejra S, Jamklnag M, Mautos JM, Gelli A. Invasion of the central nervous system by Cryptococcus neoformans requires a secreted fungal metalloprotease. mBio. 2014 Jun 3;5(3):e01101-14. PMID: 24895304
*IDWeek 2012TM Program Committee Choice Award - given to the four best accepted abstracts overall at IDWeek - 50th Annual Infectious Diseases Society of America (IDSA) Meeting. San Diego, CA: 2012.
*Featured in Faculty of 1000: http://f1000.com/prime/718433707.
Marsden-Haug N, Hill H, Litvintseva AP, Engelthaler D, Driebe EM, Roe CC, Ralston C, Hurst S, Goldoft M, Gade L, Wohrle R, Thompson GR III, Brandt M, Chiller T, Washington State Department of Health. Notes from the Field: Coccidioides immitis Identified in Soil Outside of Its Known Range - Washington, 2013. MMWR Morbidity and Mortality Weekly Report. 2014 May 23;63(20):450. PMID: 24848217
Jiang G, Mendes EA, Kaiser P, Sankaran-Walters S, Tang Y, Weber MG, Melcher GP, Thompson GR III, Tanuri A, Pianowski LF, Wong JK, Dandekar S. Reactivation of HIV latency by a newly modified Ingenol derivative via PKCδ-NFκB signaling. AIDS. 2014 Jul 17;28(11):1555-66. PMID: 24804860
Thompson GR III, Albert N, Hodge G, Wilson MD, Sykes JE, Bays DJ, Firacative C, Meyer W, Kontoyiannis DP. Phenotypic Differences of Cryptococcus genotypes: implications for virulence in a Drosophila model of infection. Infection and Immunity. 2014 July;82(7):3058-3065. PMID: 24799631
