Kermit L. Carraway, III, Ph.D.

Rm 1100B Research III Building
Sacramento Campus
Ph: 916-734-3114
Fax: 916-734-0190

Research Interests

The lab uses biochemical, cell biological, pharmacological and genetic methods to dissect the roles of growth factors, their receptors and modulator proteins in mammalian development and in tumor initiation and progression. We are particularly interested in mechanisms of receptor ubiquitination and degradation, and how these processes impact the receptor overexpression that drives the malignancy of breast and brain tumors.

Graduate Group Affiliations

VanderVorst, K., Dreyer, C.A., Konopelski, S.E., Lee, H., Ho, H.H., and Carraway, K.L., III. 2019. Wnt/PCP signaling contribution to carcinoma collective cell migration and metastasis. Cancer Res 79, 1719-1729.

Saldana, M., VanderVorst, K., Berg, A.L., Lee, H., and Carraway, K.L, III. 2018. Otubain 1: a non-canonical deubiquitinase with an emerging role in cancer. Endcr. Relat. Cancer 26, R1-R14.

VanderVorst, K., Hatakeyama, J., Berg, A., Lee, H., and Carraway, K.L., III. 2018. Cellular and molecular mechanisms underlying planar ell polarity contributions to cancer malignancy. Semin. Cell Dev. Biol. 81, 78-87.

Rowson-Hodel, A.R., Wald, J.H., Hatakeyama, J., O'Neal, W.K., Stonebraker, J.R., VanderVorst, K., Saldana, M.J., Borowsky, A.D., Sweeney, C., and Carraway, K.L., III. 2017. Membrane mucin Muc4 promotes blood cell association with tumor cells and mediates efficient metastasis in a mouse model of breast cancer. Oncogene 37, 197-207.

Wald, J.H., Hatakeyama, J., Printsev, I., Cuevas, A., Fry, W.H.D., Saldana, M.J., VanderVorst, K., Rowson-Hodel, A., Angelastro, J.M., Sweeney, C., and Carraway, K.L., III. 2017. Suppression of planar cell polarity signaling and migration in glioblastoma by Nrdp1-mediated Dvl polyubiquitination. Oncogene 36, 5158-5167.

Printsev, I., Curiel, D., and Carraway, K.L., III. 2017. Membrane protein quantity control at the endoplasmic reticulum. J. Memb. Biol. 250, 379-392.

Hatakeyama, J., Wald, J.H., Rafidi, H., Cuevas, A., Sweeney, C., and Carraway, K.L., III. 2016. The structural protein Rtn4A stabilizes and enhances signaling through the receptor tyrosine kinase ErbB3. Sci. Signal. 9, ra65.

Rowson-Hodel, A.R., Berg, A.L., Wald, J.H., Hatakeyama, J., VanderVorst, K., Curiel, D.A., Leon, L.J., Sweeney, C., and Carraway, K.L. III. 2016. Hexamethylene amiloride engages a novel reactive oxygen species- and lysosome-dependent programmed necrotic mechanism to selectively target breast cancer cells. Cancer Lett. 375, 62-72.

Printsev, I., Yen, L., Sweeney, C., and Carraway, K.L., III. 2014. Oligomerization of the Nrdp1 E3 ubiquitin ligase is necessary for efficient autoubiquitination but not ErbB3 ubiquitination. J. Biol. Chem. 289, 8570-85788.

Hatakeyama, J., Wald, J.H., Printsev, I., Ho, H.Y., and Carraway, K.L., III. 2014. Vangl1 and Vangl2: planar cell polarity components with a developing role in cancer. Endocr Relat Cancer 21, R345-356.

Leon, L.J., Pasupuleti, N., Gorin, F., and Carraway, K.L., III. 2013. A cell-permeant amiloride derivative induces caspase-independent, AIF-mediated programmed necrotic death of breast cancer cells. PLoS One 8, e63038.

Fry, W.H., Simion, C., Sweeney, C., and Carraway, K.L. III. 2011. Quantity control of the ErbB3 receptor tyrosine kinase at the endoplasmic reticulum. Mol. Cell. Biol. 31, 3009-3018.

Carraway, K.L., III. 2010. E3 ubiquitin ligases in ErbB receptor quantity control. Sem. Cell Dev. Biol. 21, 936-943.

Ingalla, E.Q., Miller, J.K., Wald, J.H., Workman, H.C., Kaur, R.P., Yen, L., Fry, W.H.D., Borowsky, A.D., Young, L.J.T., Sweeney, C., and Carraway, K.L., III. 2010. Post-transcriptional regulatory mechanisms contribute to the suppression of the ErbB3 negative regulator protein Nrdp1 in mammary tumors. J. Biol. Chem. 285, 28691-28697.

Workman, H.C., Miller, J.K., Ingalla, E.Q., Kaur, R.P., Yamamoto, D.I., Beckett, L.A., Young, L.J., Cardiff, R.D., Borowsky, A.D., Carraway, K.L., Sweeney, C., and Carraway, K.L., III. The membrane mucin MUC4 is elevated in breast tumor lymph node metastases relative to matched primary tumors and confers aggressive properties to breast cancer cells. Breast 2009b. 11, R70. PMID: 19761616

Workman, H.C., Sweeney, C., and Carraway, K.L., III. The membrane mucin Muc4 inhibits apoptosis induced by multiple insults via ErbB2-dependent and ErbB2-independent mechanisms. Cancer 2009a. Res. 69, 2845-2852. PMID: 19293191

Miller, J.K., Shattuck, D.L., Ingalla, E.Q., Yen, L., Borowsky, A.D., Young, L.J., Cardiff, R.D., Carraway, K.L., III, and Sweeney, C. Suppression of the negative regulator LRIG1 contributes to ErbB2 overexpression in breast cancer. Cancer 2008. Res. 68, 8286-8294. PMID: 18922900

Cao, Z., Wu, X., Yen, L., Sweeney, C. and Carraway, K.L. III. Neuregulin induced ErbB3 down-regulation is mediated by a protein stability cascade involving the E3 ubiquitin ligase Nrdp1. Mol Cell Biol 2007. 27, 2180-2188. PMID: 17210635

Ballif, B. A., Cao, Z., Schwartz, D., Carraway, K. L., III, and Gygi, S. P. Identification of 14-3-3epsilon substrates from embryonic murine brain. J Proteome 2006. Res 5, 2372-2379. PMID: 16944949

Yen, L., Cao, Z., Wu, X., Ingalla, E. R., Baron, C., Young, L. J., Gregg, J. P., Cardiff, R. D., Borowsky, A. D., Sweeney, C., and Carraway, K. L., III. Loss of Nrdp1 enhances ErbB2/ErbB3-dependent breast tumor cell growth. Cancer Res. 2006. 66, 11279-11286. PMID: 17145873

Wu, X., Yen, L., Irwin, L., Sweeney, C., and Carraway, K. L., III. Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8. Mol. Cell. Biol. 2004. 24, 7748-7757. PMID: 15314180

Ghiglione, C., Carraway, K.L. III, Amundadottir, L.T., Boswell, R.E., Perrimon, N. and Duffy, J.B. The transmembrane molecule Kekkon-1 acts in a feedback loop to negatively regulate the activity of the Drosophila EGF receptor during oogenesis. Cell 1999. 96, 847-856. PMID: 10102272

Carraway, K.L., III, Weber, J.L., Unger, M.J., Ledesma, J., Yu, N., Gassmann, M., and Lai, C. Neuregulin-2, a new ligand of ErbB3/ErbB4-receptor tyrosine kinases. Nature 1997. 387, 512-516. PMID: 9168115

Upper Division Courses

  • 199 Special Study for Advanced Undergraduates

Graduate Courses

  • BCM299 Research
  • MCB257 Cell Proliferation and Cancer Genes

Professional Courses for Medical Students

  • BCM410A Medical Biochemistry
  • BCM410B Cell Biology and Metabolism