Luis G Carvajal Carmona, Ph.D.

Professor and Auburn Community Cancer Endowed Chair in Basic Science
Associate Vice Chancellor for the Office of Academic Diversity
451 Health Sciences Drive
Davis Campus
Ph: 530-752-9654
e-mail
Lab Website

Research Interests

Our research group is interested in the study of cancer genetic susceptibility and of cancer genomics in diverse populations. We use genetic, genomic and functional approaches to identify novel cancer-causing gene and mutations in human populations, to investigate the function of genetic variation associated with disease and to carry out pre-clinical studies aimed at developing better molecularly guided therapies. We are also interested in investigating somatic genetic pathways and clonal architecture of common cancer types. An important number of our studies focus on the genetics and epidemiology of cancer in Latinos, for which we have developed long-standing collaborations with researchers in Latin America and Europe. At the UC Davis School of Medicine, we are active members of our Comprehensive Cancer Center where I am the Associate Director for the Inclusivity, Diversity, Equity and Accessibility (IDEAL) Office. At our cancer center I am also the Founder Director of the Center for Advancing Cancer Health Equity and the Latinos United for Cancer Health Advancement (LUCHA) Initiative. I am also the Associate Vice Chancellor for the Office of Academic Diversity in the UC Davis Office of Diversity, Equity and Inclusion.

Graduate Group Affiliations

See: A complete and updated list of publications »

Halmai N, O’Geen H, Lott P, Segal D, Carvajal-Carmona L. "Scarless genome editing reveals risk SNP rs6983267-G and lncRNA CCAT2 dictate targetable PI3K signaling dependence in WNT-dysregulated colorectal cancer". Submitted to Molecular Cancer Research.

Perez-Gove F, Hernandez M, Martinez A, Castaneda P, Ponce R, Gonzalez M, Martinez C, Perez A, Quino E, Robles Garibay E, Zavala VA, Huang X, Neuhausen S, Ziv E, Carvajal-Carmona L, Duron Y, Fejerman L. "Promotores’ perspectives on the virtual adaptation of a hereditary breast cancer education program". Submitted to Family and Community Health.

Sanderson BJ, Lott P, Chiu K, Quino JE, Vang AP, Lloyd MW, Srivastava A, PDXNet Consortium, Chuang JH, Carvajal-Carmona LG. "Development and application of genetic ancestry reconstruction methods to study diversity of patient-derived models in the NCI PDXNet Consortium". bioRxiv, doi: https:10.1101/2022.10.24.513591.

Halmai N, Carvajal-Carmona GL. "Advancing gastric cancer precision medicine with novel genomic screens". Journal of Pathology. In press. doi: 10.1002/path.6046

Cardoso M, Maia S, Brandão A, Sahasrabudhe R, Lott P, Belter N, Carvajal-Carmona L, Paulo P, Teixeira M. "Exome sequencing of affected duos and trios uncovers PRUNE2 as novel prostate cancer predisposition gene". British Journal of Cancer, In press. Doi: 10.1038/s41416-022-02125-6.

Oh D, Meltzer D, Wang K, Canchola AJ, DeRouen MC, McDaniels-Davidson C, Gibbons J, Carvajal-Carmona L, Nodora JN, Hill L, Lin Gomez S, Martinez ME. "Neighborhood factors associated with COVID-19 cases in California". Journal of Racial and Ethnic Disparities. 2022, 14:1-14. doi: 10.1007/s40615-022-01443-y.

Tamayo LI, Perez F, Perez A, Hernandez M, Martinez A, Huang X, Zavala V, Ziv A, Neuhausen S, Carvajal-Carmona L, Durin Y, Fejerman L. "Cancer screening and breast cancer family history in Spanish-speaking Hispanic/Latina women in California". Frontiers in Oncology. 2022, 12: 940162. doi: https://doi.org/10.3389/fonc.2022.940162.

ToalT, Estrada-Florez A, Polanco-Echeverry G, Sahasrabudhe R, Lott P, Suarez-Olaya J, Guevara-Tique A, Castro-Valencia F, Urayama S, Kirane A, Wei D, Rios-Sarabia N, Medrano R, Mantilla A, Echeverry de Polanco M, Torres J, Bohorquez-Lozano M, Carvajal-Carmona LG. "Multi-Regional Sequencing Analysis Reveals Extensive Genetic Heterogeneity in Gastric Cancer". Cancer Research Communications. 2022, 2(11): 1487-1496. doi: 10.1158/2767-9764.CRC-22-0149.

Guevara-Tiqu AA, Torres RC, Bravo MM, Carvajal-Carmona LG, Echeverry de Polanco MM, Bohorquez ME, Torres J. "Recombination events drives the emergence of Colombian Helicobacter pylori subpopulations with self-identity ancestry". Virulence, 2022, 13(1):1146-1160. doi: 10.1080/21505594.2022.2095737.

Quino JE, Perez F, Perez A, Vang A, Avendano L, Dang J, Chen M, Morales Arana A, Rocha S, Nuno M, Lara P, Fejerman L, Carvajal-Carmona L. "A cancer health needs assessment reveals important differences between US-born and foreign-born Latinos in California". Frontiers in Oncology. 2022, 12:883200. doi: 10.3389/fonc.2022.883200.

Macauda A, Clay-Gilmour A, Hielscher T, Hildebrandt MAT, Kruszewski M, Orlowski RZ, Kumar SK, Ziv E, Orciuolo E, Brown EE, Försti A, Waller RG, Machiela MJ, Chanock SJ, Camp NJ, Rymko M, Ra┼║ny M, Cozen W, Varkonyi J, Piredda C, Pelosini M, Belachew AA, Subocz E, Hemminki K, Rybicka-Ramos M, Giles GG, Milne RL, Hofmann JN, Zaucha JM, Vangsted AJ, Goldschmidt H, Rajkumar SV, Tomczak W, Sainz K, Butrym A, Watek M, Iskierka-Jazdzewska E, Buda G, Robinson DP, Jurczyszyn A, Dudzinski M, Martinez-Lopez J, Sinnwell JP, Slager SL, Jamroziak K, Vieira Reis RM, Weinhold N, Bhatti P, Carvajal-Carmona L, Zawirska D, Norman AD, Mazur G, Berndt SI, Campa D, Vachon CM, Canzian F. "Does a Multiple Myeloma Polygenic Risk Score Predict Overall Survival of Myeloma Patients" Cancer Epidemiology Biomarkers & Prevention. 2022, 2;31:1863-1866. doi: 10.1158/1055-9965.EPI-22-0043.

Koc S, Lloyd MW, Grover J, Seepo S, Subramanian SL, Ray M, Frech C, DiGiovanna J, Webster P, Neuhauser S, Srivastava A, Woo XY, Sanderson BJ, White B, Lott P, Evrard YA, Wallace TA, Moscow JA, Doroshow JH, Mitsiades N, Kaochar S, Pan C, Chen S, Carvajal-Carmona L, Welm, AL Welm BE, Lewis MT, Ramaswarmy G, Ding L, Li S, Herlyn M, Davies M, Roth J, Meric-Bernstam F, Robinson PN, Bult CJ, Davis-Dusenbery B, Dean DA, Chuang JH, "PDXNet Consortium. PDXNet Portal: Patient-Derived Xenograft model, data, workflow, and tool discovery". Nucleic Acids Research. 2022, 22;4:zcac014. doi: 10.1093/narcan/zcac014.

Halmai NB, Carvajal-Carmona LG. "Diversifying preclinical research tools: expanding patient-derived models to address cancer health disparities". Trends in Cancer. 2022, 8: 291-294.

Colistro V, Rojas-Martinez A, Carracedo Alvarez A, CHIBCHA Consortium, Tomlinson I, Carvajal-Carmona L, Cruz R, Sans M. "Population structure and relatedness estimates in a Mexican sample". Annals of Human Genetics. 2021, 85:245-248. doi: 10.1111/ahg.12421.

Sun H, Cao S, Mashl RJ, Mo CCH, Zaccaria S, Wendl MC, Davies SR, Bailey MH, Primeau TM, Hoog J, \ Mudd JL, Dean DA, Patidar R, Chen L, Wyczalkowski MA, Jayasinghe RG, Rodrigues FM,  Terekhanova NV, Li Y, Lim KH, Wang-Gillam A, Van Tine BA, Ma CX. Aft R, Fuh KC, Dipersio JF, The NCI PDXNet Consortium; Davis-Dusenbery B, Lewis MT, Davies M; Herlyn M, Fang B; Roth JA, Welm AL, Welm BE, Meric-Bernstam F, Chen F, Fields RC, Li S, Govindan R, Doroshow JH, Moscow JA, Evrard YA, Raphael BJ, Chuang JH; Ding L. "Comprehensive characterization of 536 patient-derived xenograft models prioritizes candidates for targeted treatment". Nature Communications. 2021, 12:5086. doi: 10.1038/s41467-021-25177-3. Carvajal-Carmona L is a member of the NCI PDXNet Consortium.

Martinez ME, Nodora JN, Carvajal-Carmona, LG. "The dual pandemic of Covid-19 and systemic inequities in U.S. Latinos". Cancer, 2021, 127:1548-1550. Doi:10.1002/cncr.33401.

Woo XY, Giordano J, Srivastava A, Zhao Z-M, Lloyd MW, de Bruijn R, Suh. Y-S, Patidar R, Chen L, Scherer S, Bailey M, Yang C-H, Cortes-Sanchez E, Xi Y, Wang J, Wickramasinghe J, Kossenkov AV, Rebecca V, Sun H, Mash RJ, Davies S, Jeon R, Frech. C, Randjelovic J, Rosains J, Galimi F, Bertotti A, Lafferty A, O’Farrell AC, Modave E, Lambrechts D, Brugge P, Serra V, Marangoni E, El Botty R, Kim H, Kim J-I, Yang H-K, Lee C, Dean II DA, Davis-Dusenbery B, Evrard YA, Doroshow JH, Welm AL, Welm BE, Lewis MT, Fang B, Roth JA, Meric-Bernstam F, Herlyn M, Davies M, Ding L, Li S, Govindan R, Isella C, Moscow. JA, Trusolino L, Byrne AT, Jonkers J, Bult CJ, Medico E, Chuang JH, "PDXNET consortium, EurOPDX consortium. Conservation of copy number profiles during engraftment and passaging of patient-derived cancer xenografts". Nature Genetics, 2021, 53:86-99. Doi: 10.1038/s41588-020-00750-6. Carvajal-Carmona L is a member of the NCI PDXNet Consortium

Tuazon AMD, Lott P, Benavides J, Bohórquez M, Ramirez C, Criollo AA, Estrada-Florez AP, Mateus G, Velez A, Carmona J, Ramirez J, Garcia E, Polanco-Echeverry G, Stultz J, Alvarez C, Tapia T, Ashton-Prolla P, Rannala B, Vega A, Lazaro C, Tornero E, Infante M, De La Hoya M, Diez O, Browning BL, Teixeira MR, Carvallo P, Echeverry de Polanco MM, Carvajal-Carmona LG. "Haplotype analysis of the internationally distributed BRCA1 c.3331_3334delCAAG founder mutation reveals a common ancestral origin in Iberia. Breast Cancer Research, 2020, 22:108. doi: 10.1186/s13058-020-01341-3.

Guevara Tique A, Torres R, Suarez Olaya J, Castro F, Parra G, Torres J, Carvajal L, Echeverry de Polanco M, Bohórquez M. "The genome sequence of three Colombian Helicobacter pylori strains isolated from Tolimense patients". Microbiology Research Announcements, 2020, 9:18: e00117-20. doi: 10.1128/MRA.00117-20.

Zavala VA, Bracci PM, Carethers JM, Carvajal-Carmona L, Coggins NB, Cruz-Correa MR, Davis M, de Smith AJ, Dutil J, Figueiredo JC, Fox R, Graves KD1, Gomez SL, Llera A, Neuhausen SL, Newman L, Nguyen T, Palmer JR, Palmer NR, Pérez-Stable EJ, Piawah S, Rodriquez EJ, Sanabria C, Schmit SL, Serrano-Gomez SJ, Stern M, Weitzel J, Yang JJ, Zabaleta J, Ziv E, Fejerman L. "Cancer health disparities in U.S. Racial/Ethnic Minorities". British Journal of Cancer, 2020, In press. https://doi.org/10.1038/s41416-020-01038-6.

Mountford HS, Villanueva P, Fernández MA, Jara L, De Barbieri Z, Carvajal-Carmona L, Cazier J-B, Newbury DF. "The Genetic Population Structure of Robinson Crusoe Island, Chile". Frontiers in Genetics, 2020, 11:669. doi: 10.3389/fgene.2020.00669

Evrard. YA, Srivastava A, Randjelovic J, NCI PDXNet Consortium, Doroshow JH, Dean DA, Morris JS, Chuang JH. "Systematic Establishment of Robustness and Standards in Patient-Derived Xenograft Experiments and Analysis". Cancer Research, 2020, doi:10.1158/0008-5472.CAN-19-3101. Carvajal-Carmona L is a member of the NCI PDXNet Consortium.

Marker K, Zavala V, Vidaurre T, Lott P, Navarro Vásquez J, Casavilca-Zambrano S, Calderon M, Abugattas J, Gómez H, Fuentes H, Liendo R, Cotrina J, Neciosup S, Castaneda C, Morante Z, Valencia F, Torres J, Echeverry M, Bohorquez M, Polanco-Echeverry G, Estrada-Florez A, Serrano-Gómez S, Carmona J, Alvarado-Cabrero I, Sanabria Salas MC, Velez A, Donado J, COLUMBUS Consortium, Song S, Cherry D, Tamayo L, Huntsman S, Hu D, Ruiz-Cordero R, Balassanian R, Ziv E, Zabaleta J, Carvajal-Carmona L, Fejerman L. "Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer is associated with Indigenous American ancestry in Latin American women". Cancer Research, 2020, doi: 10.1158/0008-5472.CAN-19-3659.

Shieh Y, Fejerman L, Lott PC, Marker K, Sawyer SD, Hu D, Huntsman S, Torres J, Echeverry M, Bohorquez ME, Martínez-Chéquer JC, Polanco-Echeverry G, Estrada-Florez AP. Haiman CA, John EM, Kushi LH, Torres-Mejía G, Vidaurre T, Weitzel JN, Casavilca Zambrano S, Carvajal-Carmona LG, Ziv E, Neuhausen SL. "A polygenic risk score for breast cancer in U.S. Latinas and Latin-American women". Journal of National Cancer Institute, 2019; 112: 590-598. doi: 10.1093/jnci/djz174.

See also Editorial: Palmer JR. "Polygenic risk scores for breast cancer risk prediction: Lessons learned and future opportunities". Journal of National Cancer Institute, 2020; 112: 555-556. doi: 10.1093/jnci/djz176.

Peterlongo P, Carvajal-Carmona LG. "Accomplishments, Collaborative Projects and Future Initiatives in Breast Cancer Genetic Predisposition". Frontiers in Oncology, 2019; 9:841. doi: 10.3389/fonc.2019.00841.

  • 2021 Chancellor’s Award for Excellence in Mentoring Undergraduate Research, UC Davis
  • 2021 ADVANCE Scholar Award for outstanding scholarship and mentorship. UC Davis Office of the Vice Chancellor for Diversity, Equity and Inclusion
  • 2021 Presidential Leadership Fellow, Hispanic Association of Colleges and Universities
  • 2018 Dean’s Fellowship in Precision Health Equity, UC Davis School of Medicine
  • 2014 K12 Paul Calabresi in Clinical Oncology
  • 2014 Latino Aging Research Resource Center Scholar
  • 2013 Outstanding Alumni Award. B.Sc. Animal Science, Universidad Nacional de Colombia.
  • 2013 V Foundation Scholar
  • 2011 Semi-finalist. Trainee Research Award, American Society for Human Genetics for abstract submission to the 12th International Congress of Human Genetics. Montreal, Canada
  • 2009 Winner of the Divisional Research Prize. Medical Sciences Division, University of Oxford.
  • 2009 Finalist. Neel Award for Young Investigators. International Genetic Epidemiology Society.
  • 2008 Winner of the European Association for Cancer Research 40th Anniversary Research Award.
  • 2004 Research Fellowship. London Research Institute, United Kingdom