Thomas Jue, Ph.D.

4323 Tupper Hall
Davis Campus
Ph: 530-752-4569

Lab Website

Research Interests

Dr. Jue applies nuclear magnetic resonance (NMR) spectroscopic/imaging, biophysical methods, and physiological techniques to investigate:

  1. Protein structure-function and metabolic regulation in vivo,
  2. Regulation of Oxidative Phosphorylation in Muscle,
  3. Altered Metabolic Regulation in Disease States,
  4. Biochemical Mechanism of Type 2 Diabetes Pathogenesis in Muscle and Brain.
  5. Increased Risk of Alzheimer's Disease with Type 2 Diabetes.

Graduate Group Affiliations


Handbook of Modern Biophysics (Series Editor)

Vol 1: Jue, T. "Fundamental Concepts in biophysics", Humana Press, 2009.

Vol 2: Jue, T., Risbud, S., Longo, M. L., Faller, R., "Biomembrane Frontiers", Humana Press, 2009.

Vol 4: Jue, T., "Biomedical Applications of Biophysics", Humana Press, NY, 2010

Vol 3: Masuda, K. and Jue, T., "Application of Near Infrared Spectroscopy in Biomedicine", Springer US, 2013

Vol 5: Jue, T., "Modern Tools of Biophysics", Springer-Verlag, NY, 2017


Journal Articles

Park JM, Josan S, Hurd RE, Graham J, Havel PJ, Bendahan D, Mayer D, Chung Y, Spielman DM, Jue T. “Hyperpolarized NMR study of the impact of pyruvate dehydrogenase kinase inhibition on the pyruvate dehydrogenase and TCA flux in type 2 diabetic rat muscle.Pflugers Arch. 2021 Nov;473(11):1761-1773. doi: 10.1007/s00424-021-02613-3. Epub 2021 Aug 20. PubMed PMID: 34415396.

Park JM, Harrison CE, Ma J, Chen J, Ratnakar J, Zun Z, Liticker J, Reed GD, Chhabra A, Haller RG, Jue T, Malloy CR. “Hyperpolarized 13C MR Spectroscopy Depicts in Vivo Effect of Exercise on Pyruvate Metabolism in Human Skeletal Muscle.Radiology. 2021 Sep;300(3):626-632. doi: 10.1148/radiol.2021204500. Epub 2021 Jun 22. PubMed PMID: 34156298; PubMed Central PMCID: PMC8409104.

Koma R, Shibaguchi T, Pérez López C, Oka T, Jue T, Takakura H, Masuda K. “Localization of myoglobin in mitochondria: implication in regulation of mitochondrial respiration in rat skeletal muscle.Physiol Rep. 2021 Mar;9(5):e14769. doi: 10.14814/phy2.14769. PubMed PMID: 33650803; PubMed Central PMCID: PMC7923563.

Jue T, editor. “Dynamic Nuclear Magnetic Resonance” [Internet] New York: Springer; 2021. 270p.

Park JM, Jue T. “Insights on Lactate Metabolism in Skeletal Muscle Based on 13C Dynamic Nuclear Polarization Studies. In: Jue T, editor. Dynamic Polarized Nuclear Magnetic Resonance” [Internet] New York: Springer; 2021. Chapter 10; p.237-251.

Kestenbaum B, Gamboa J, Liu S, Ali AS, Shankland E, Jue T, Giulivi C, Smith LR, Himmelfarb J, de Boer IH, Conley K, Roshanravan B. “Impaired skeletal muscle mitochondrial bioenergetics and physical performance in chronic kidney disease. JCI Insight. 2020 Mar 12;5(5). doi: 10.1172/jci.insight.133289. PubMed PMID: 32161192; PubMed Central PMCID: PMC7141399.

Chung Y, Mohanakrishnan R, Brossmer R, Gong Q, Lönnerdal B, Jue T. “A mouse model and 19 F NMR approach to investigate the effects of sialic acid supplementation on cognitive development. FEBS Lett. 2020 Jan;594(1):135-143. doi: 10.1002/1873-3468.13548. Epub 2019 Aug 3. PubMed PMID: 31325365.

Bendahan, D., Chatel, B, and Jue, T. “Comparative NMR and NIRS analysis of oxygen dependent metabolism in exercising finger flexor muscles”, 2017 Am. J. Physiology DOI: 10.1152/ajpregu.00203.2017

Jue, T., Shih, L., Chung, Y., “Differential interaction of myoglobin with select fatty acids of carbon chain lengths C8 to C16”, Lipids, 2017. DOI 10.1007/s11745-017-4272-z

Jue, T., Simond, G., Wright, T. J., Shih, L., Chung, Y., Sriram, R., Kreutzer, U., and Davis, R., “Effect of fatty acid interaction on Mb oxygen affinity and triglyceride metabolism”, J. Physiol. and Biochem, 2017. doi:10.1007/s13105-017-0559-z

Masuda, K., Jue, T., Hamidie, R.D.R., “Mitochondrial biogenesis induced by exercises and nutrients: Implication for performance and health benefits”, Indonesian J of Sci & Tech, 2, 99-107, 2017. DOI:

Takura, H., Ojino, M., Jue, T., Yamada, T., Furuchi, Y., Hashimoto, T., Iwase, S., and Masuda, K. “Intracellular oxygen tension limits muscle contraction-induced change in muscle oxygen consumption under hypoxic conditions during Hb-free perfusion”, Physiol. Reports, 5 (2), 1-10, 2017. e13112. doi: 10.14814/phy2.13112.

Yamada, T., Takakura, H., Jue, T. Hashimoto, T. Ishizawa, R. Furuichi, Y. Kato, Y., Iwanaka, N. Masuda, K. “Myoglobin and the regulation of mitochondrial respiratory chain complex IV”. J. Physiol., 594, 483-495, 2016. doi: 10.1113/JP270824.

Shih, L., Chung, Y., Sriram, R., and Jue, T.Interaction of myoglobin with oleic acid”. Chem Phys Lipids, 191, 115-122, 2015. doi: 10.1016/j.chemphyslip.2015.07.010.

Park, J.M., Josan, S., Mayer, D., Hurd, R. E., Chung, Y., Bendahan, D., Spielman, D. M., and Jue, T., “Hyperpolarized 13C NMR Observation of Lactate Kinetics in Skeletal Muscle”, J Exp Biol, 18,3308-3318,2015. DOI: 10.1113/JP270824.

Jue, T., Measuring Intracellular Oxygenation with the Myoglobin Signals, Encyclopedia of Magnetic Resonance, ed by John Griffiths and Paul Bottomley, John Wiley & Sons, 4, 635-642, 2015. DOI: 10.1002/9780470034590.emrstm1452.

Takakura, H., Furuichi,Y.Yamada, T., Jue, T., Ojino, M., Hashimoto, T., Iwase, S., Hojo, T., Izawa, T., Masuda, K., “Endurance training facilitates myoglobin desaturation during muscle contraction in rat skeletal muscle”, Scientific Report, 5, 9403, 1-6, 2014. doi:10.1038/srep09403.

Shih, L., Chung, Y., Sriram, R., and Jue, T., “Palmitate Interaction with Physiological States of Myoglobin”. Bioch BiophyActa, 1840, 656-666, 2014. DOI: 10.1016/j.bbagen.2013.10.028.

Yamada, T. Yasuro, F., Hisashi, T., Hashimoto, T. Hanai, Y., Jue, T, and Masuda, K., “Interaction between myoglobin and mitochondria in rat skeletal muscle”, J. Appl. Physiol., 114(4):490-7, 2013. doi: 10.1152/japplphysiol.00789.2012.

Sriram, R. Lagerstedt, J.O., Petrolova, J., Samardzic, H. Kreutzer, U., Xie, Hongtao, Kaysen, G. A., Desreux, J.F., Thonon, D. F., Jacques, V., Van Loan, M., Rutledge, J. C., Oda, M. N., Voss, J. C., and Jue, T.Imaging apolipoprotein AI in vivo”. NMR in Biomedicine 24, 916-24, 2011. doi: 10.1002/nbm.1650.

Gros, G., Wittenberg, BA, and Jue, T.Myoglobin’s old and new clothes: form molecular structure to function in living cells”. J. Exp. Biol 213: 2713-2725, 2010. doi: 10.1242/jeb.043075.

Tomita, A., Kreutzer, U., Adachi, S., Koshihara, SY, and Jue, T.'It's hollow': the function of pores within myoglobin.J. Exp. Biol. 213: 2748-2754, 2010. doi: 10.1242/jeb.042994.

Takakura, H., Masuda, K., Hashimoto, T., Iwase, S., and Jue, T.Quantificatiion of myoglobin deoxygenation and intracellular partial pressure of O2 during muscle contraction during haemoglobin-free medium perfusion”, Exp. Physiol. 95, 630-640, 2010. doi: 10.1113/expphysiol.2009.050344.

Xie, H., Kreutzer, U., and Jue, T.Oximetry with the NMR signals of hemoglobin Val E11 and Tyr C7”. Eur J Appl Physiol. 107, 325-33, 2009. DOI 10.1007/s00421-009-1125-3.

Sriram, R., Kreutzer, U., Shih, L., Jue, T.Interaction of fatty acid with myoglobin”. FEBS Lett, 582(25-26): 3643-9, 2008. doi: 10.1016/j.febslet.2008.09.047.

Ponganis, P. J., Kreutzer, U., Stockard, T. K., Lin, P. C., Sailasuta, N., Tran, T. K., Hurd, R., Jue, T.Blood flow and metabolic regulation in seal muscle during apnea”. J Exp Biol, 211 (Pt 20): 3323-32, 2008. doi: 10.1242/jeb.018887.

Lin, P. C., Kreutzer, U., Jue, T.Anisotropy and temperature dependence of myoglobin translational diffusion in myocardium: implication for oxygen transport and cellular architecture”. Biophys J, 92(7): 2608-20, 2007. doi: 10.1529/biophysj.106.094458.

Lower Division Courses

First Year Seminar (FYS) Trump's Immigration Ban, Chinese Exclusion Acts, and the Politics of Black Death

Upper Division Courses

  • BCM 192 Internship in Biological Chemistry
  • BCM 198 Group Study
  • BCM 199 Special Study for Advanced Undergraduates

Graduate Courses

  • BCM 214 Molecular Medicine
  • BCM 231 Biomedical NMR (same as BPH 231)
  • BCM 291 Human Genetics Seminar
  • BCM 298 Group Study
  • BCM 299 Research
  • BPH 200B Current Techniques of Biophysics

Professional Courses for Medical Students

  • BCM 410A Molecular and Cell Biology
  • BCM 410B Cell Biology and Metabolism
  • BCM 414 Molecular Medicine
  • BCM 497 Tutoring in Biological Chemistry
  • BCM 498 Group Study
  • BCM 499 Research

  • Handbook of Modern Biophysics