Su Hao Lo, Ph.D.

Research I Room 3002
Ph: 916-734-3656

Research Interests

Signal transduction mediated through focal adhesions and their roles in tissue and disease development.

Graduate Group Affiliations

Bruns A and Lo SH. TNS1 regulates Pharyngeal pumping in Caenorhabditis elegans. 2019 pii: S0006-291X(19)32281-8. doi: 10.1016/j.bbrc.2019.11.153. [Epub ahead of print]

Wu, Z. Y., Chiu, C. L., Lo, E., Lee, Y. R., Yamada, S., and Lo, S. H.*. Hyperactivity of Mek in TNS1 knockouts leads to potential treatments for cystic kidney diseases. Cell Death & Disease. 2019 10:871 doi: 10.1038/s41419-019-2119-7. PMID:31740667 PMCID: PMC6861224

Cheah, J. S., Jacobs, K. A., Heinrich, V., Lo, S. H., and Yamada, S. Force-induced recruitment of cten along keratin network in epithelial cells. 2019 Proc. Natl. Acad. Sci 116:19799-19801

Hong, S. Y., Shih, Y. P., Lo, A., Lo, S. H. Identification of subcellular targeting sequences of Cten reveals its role in cell proliferation. BBA Molecular Cell Research 2019 Mar;1866(3):450-458.

Shih, Y. P., Yuan, S. Y., Lo, S. H. Down-regulation of DLC1 in endothelial cells compromises the angiogenesis process. Cancer Letters 2017 398:46-51.

Lo, S. H. Quick guide: Tensins. Current Biology 2017 27(9):R331-R332.

Hong, S. Y., Shih, Y.P., Sun, P., Hsieh, W. J., Lin, W. C. and Lo, S. H., Down-regulation of tensin2 enhances tumorigenicity and is associated with a variety of cancers. Oncotarget 2016 Jun 21;7(25):38143-38153.

Yang, K., Wu, W. M., Chen, Y. C., Lo, S. H., and Liao Y.C. ΔNp63α Transcriptionally Regulates the Expression of CTEN that Is Associated with Prostate Cell Adhesion. PLoS ONE 2016 11(1):e0147542.

Shih YP, Sun P, Wang A, Lo SH., Tensin1 positively regulates RhoA activity through its interaction with DLC1., Biochim Biophys Acta. 2015 Sep 28;1853(12):3258-3265.

Dina C, Bouatia-Naji N, Tucker N, Delling FN, Toomer K, Durst R, Perrocheau M, Fernandez-Friera L, Solis J; PROMESA investigators, Le Tourneau T, Chen MH, Probst V, Bosse Y, Pibarot P, Zelenika D, Lathrop M, Hercberg S, Roussel R, Benjamin EJ, Bonnet F, Lo SH., Dolmatova E, Simonet F, Lecointe S, Kyndt F, Redon R, Le Marec H, Froguel P, Ellinor PT, Vasan RS, Bruneval P, Markwald RR, Norris RA, Milan DJ, Slaugenhaupt SA, Levine RA, Schott JJ, Hagege AA, Mvp-France, Jeunemaitre X; Leducq Transatlantic MITRAL Network., Genetic association analyses highlight biological pathways underlying mitral valve prolapse., Nat Genet. 2015 Oct;47(10):1206-11.

Lo. S.H. C-terminal tensin-like (CTEN): a promising biomarker and target for cancer. J Biochem Cell Biol. 2014, 51:150-4.

Hong, S. Y., Shih, Y. P., Li, T., Carraway, K., Lo, S.H. CTEN Prolongs Signaling by EGFR through Reducing Its Ligand-Induced Degradation. Cancer Res. 2013, 73(16):5266-76.

Shi L, Li, J.R., Shih, Y.P., Lo, S. H., Liu, G. Y., Nanogratings of Fibronectin Provide an Effective Biochemical Cue for Regulating Focal Adhesion and Cellular Structure. Nano Res 2012, 8): 565–575

Li, J.R., Shi, L., Deng, Z., Lo, S. H., Liu, G.Y. Nanostructures of Designed Geometry and Functionality Enable Regulation of Cellular Signaling Processes. Biochemistry 2012, 51, 5876–5893

Shih Y.P., Takada, Y., Lo, S.H. Silencing of DLC1 promotes PAI-1 expression and reduces normal cell migration. Mol Cancer Res. 2012, 10:34-39.

Shih, Y.P., Liao, YC., Lin, Y., Lo, S. H. DLC1 negatively regulates angiogenesis in a paracrine fashion. Cancer Res 2010, 70:8270-8275.

Lin, Y., Chen, N. T., Shih,Y. P., Liao, Y. C., Xue, L., and Lo, S. H, DLC2 modulates angiogenic responses in vascular endothelial cells by regulating cell attachment and migration. Oncogene 2010, 29:3010-3016

Liao, Y. C., Chen, N. T., Shih Y. P., Dong, Y., Lo, S. H. Up-regulation of C-terminal tensin-like molecule promotes the tumorigenicity of colon cancer cells through b-catenin. Cancer Res 2009, 69:4563- 4566.

Upper division courses

  • 192 Internship in Biological Chemistry
  • 198 Group Study
  • 199 Special Study for Advanced Undergraduates

Graduate courses

  • 209 Prostaglandins/Leukotrienes and Related Lipids (offered even years)
  • 214 Molecular Medicine
  • 217 Molecular Genetics of Fungi (odd years)
  • 222 Mechanisms of Translational Control (even years)
  • 230 Practical NMR
  • 231 Biomedical NMR (same as BPH 231)
  • 291 Human Genetics Seminar
  • 298 Group Study
  • 299 Research

Professional courses for medical students

  • 410A Molecular and Cell Biology
  • 410B Cell Biology and Metabolism
  • 414 Molecular Medicine
  • 491 Human Genetics Seminar
  • 497 Tutoring in Biological Chemistry
  • 498 Group Study
  • 499 Research

Current Lab Members

  • Dr. Ying Tan
  • Dr. Chun-Lung (Jason) Chiu

Previous Lab Members