Su Hao Lo, Ph.D.

Fan W, Adebowale K, Váncza L, Li Y, Rabbi MF, Kunimoto K, Chen D, Mozes G, Chiu DK, Li Y, Tao J, Wei Y, Adeniji N, Brunsing RL, Dhanasekaran R, Singhi A, Geller D, Lo SH, Hodgson L, Engleman EG, Charville GW, Charu V, Monga SP, Kim T, Wells RG, Chaudhuri O, Török NJ. "Matrix viscoelasticity promotes liver cancer progression in the pre-cirrhotic liver". Nature. 2024 Feb;626(7999):635-642. doi: 10.1038/s41586-023-06991-9. Epub 2024 Jan 31. PMID: 38297127; PMCID: PMC10866704.

Lee YJ, Yamada S, Lo SH. “Phase transition of tensin-1 during the focal adhesion disassembly and cell division”,. Proc Natl Acad Sci U S A. 2023 120(15):e2303037120. doi: 10.1073/pnas.2303037120. Epub 2023 Apr 3. PMID: 37011205

Huang, CW., and Lo, SH. "Tensins in Kidney Function and Diseases". Life (Basel) 2023 24;13(6):1244. doi: 10.3390/life13061244.

Merour E, Hmidan H, Marie C, Helou PH, Lu H, Potel A, Hure JB, Clavairoly A, Shih YP, Goudarzi S, Dussaud S, Ravassard P, Hafizi S, Lo SH, Hassan BA, Parras C. "Transient regulation of focal adhesion via Tensin3 is required for nascent oligodendrocyte differentiation". Elife. 2022 Oct 10;11:e80273. doi: 10.7554/eLife.80273. PMID: 36214451; PMCID: PMC9596163.

Chun-Lung Chiu, Shiao-Ya Hong, Ying Tan, Yuh-Ru Julie Lee, Yi-Ping Shih, Clifford G. Tepper, Su Hao Lo, "C-terminal tensin-like (CTEN) knockin alleviates cystic kidney defects in Tensin-1 knockout mice", Genes & Diseases, 2022, ISSN 2352-3042, https://doi.org/10.1016/j.gendis.2022.05.035.

Liao YC, Lo SH. "Tensins - emerging insights into their domain functions, biological roles and disease relevance". J Cell Sci. 2021 Feb 17;134(4):jcs254029. doi: 10.1242/jcs.254029. PMID: 33597154.

Tan Y, Lo SH. "Endothelial DLC1 is dispensable for liver and kidney function in mice". Genes Dis. 2020 Nov 28;9(3):814-819. doi: 10.1016/j.gendis.2020.11.012. PMID: 35782987; PMCID: PMC9243348.

Ogorodnik E, Karsai A, Wang KH, Liu FT, Lo SH, Pinkerton KE, Gilbert B, Haudenschild DR, Liu GY. "Direct Observations of Silver Nanowire-Induced Frustrated Phagocytosis among NR8383 Lung Alveolar Macrophages". J Phys Chem B. 2020 Dec 24;124(51):11584-11592. doi: 10.1021/acs.jpcb.0c08132. Epub 2020 Dec 11. PMID: 33306381; PMCID: PMC7869824.

Bruns A and Lo SH. "TNS1 regulates Pharyngeal pumping in Caenorhabditis elegans". 2019 pii: S0006-291X(19)32281-8. doi: 10.1016/j.bbrc.2019.11.153. [Epub ahead of print]

Wu, Z. Y., Chiu, C. L., Lo, E., Lee, Y. R., Yamada, S., and Lo, S. H.*. "Hyperactivity of Mek in TNS1 knockouts leads to potential treatments for cystic kidney diseases". Cell Death & Disease. 2019 10:871 doi: 10.1038/s41419-019-2119-7. PMID:31740667 PMCID: PMC6861224

Cheah, J. S., Jacobs, K. A., Heinrich, V., Lo, S. H., and Yamada, S. "Force-induced recruitment of cten along keratin network in epithelial cells". 2019 Proc. Natl. Acad. Sci 116:19799-19801

Hong, S. Y., Shih, Y. P., Lo, A., Lo, S. H. "Identification of subcellular targeting sequences of Cten reveals its role in cell proliferation". BBA Molecular Cell Research 2019 Mar;1866(3):450-458.

Shih, Y. P., Yuan, S. Y., Lo, S. H. "Down-regulation of DLC1 in endothelial cells compromises the angiogenesis process". Cancer Letters 2017 398:46-51.

Lo, S. H. "Quick guide: Tensins". Current Biology 2017 27(9):R331-R332.

Hong, S. Y., Shih, Y.P., Sun, P., Hsieh, W. J., Lin, W. C. and Lo, S. H., "Down-regulation of tensin2 enhances tumorigenicity and is associated with a variety of cancers". Oncotarget 2016 Jun 21;7(25):38143-38153.

Yang, K., Wu, W. M., Chen, Y. C., Lo, S. H., and Liao Y.C. "ΔNp63α Transcriptionally Regulates the Expression of CTEN that Is Associated with Prostate Cell Adhesion". PLoS ONE 2016 11(1):e0147542.

Shih YP, Sun P, Wang A, Lo SH., "Tensin1 positively regulates RhoA activity through its interaction with DLC1.", Biochim Biophys Acta. 2015 Sep 28;1853(12):3258-3265.

Dina C, Bouatia-Naji N, Tucker N, Delling FN, Toomer K, Durst R, Perrocheau M, Fernandez-Friera L, Solis J; PROMESA investigators, Le Tourneau T, Chen MH, Probst V, Bosse Y, Pibarot P, Zelenika D, Lathrop M, Hercberg S, Roussel R, Benjamin EJ, Bonnet F, Lo SH., Dolmatova E, Simonet F, Lecointe S, Kyndt F, Redon R, Le Marec H, Froguel P, Ellinor PT, Vasan RS, Bruneval P, Markwald RR, Norris RA, Milan DJ, Slaugenhaupt SA, Levine RA, Schott JJ, Hagege AA, Mvp-France, Jeunemaitre X; Leducq Transatlantic MITRAL Network., "Genetic association analyses highlight biological pathways underlying mitral valve prolapse"., Nat Genet. 2015 Oct;47(10):1206-11.

Lo. S.H. "C-terminal tensin-like (CTEN): a promising biomarker and target for cancer". J Biochem Cell Biol. 2014, 51:150-4.

Hong, S. Y., Shih, Y. P., Li, T., Carraway, K., Lo, S.H. "CTEN Prolongs Signaling by EGFR through Reducing Its Ligand-Induced Degradation". Cancer Res. 2013, 73(16):5266-76.

Shi L, Li, J.R., Shih, Y.P., Lo, S. H., Liu, G. Y., "Nanogratings of Fibronectin Provide an Effective Biochemical Cue for Regulating Focal Adhesion and Cellular Structure". Nano Res 2012, 8): 565–575

Upper Division Courses

• 192 Internship in Biological Chemistry
• 198 Group Study
• 199 Special Study for Advanced Undergraduates

Graduate Courses

• 209 Prostaglandins/Leukotrienes and Related Lipids (offered even years)
• 214 Molecular Medicine
• 217 Molecular Genetics of Fungi (odd years)
• 222 Mechanisms of Translational Control (even years)
• 230 Practical NMR
• 231 Biomedical NMR (same as BPH 231)
• 291 Human Genetics Seminar
• 298 Group Study
• 299 Research

Professional Courses for Medical Students

• 410A Molecular and Cell Biology
• 410B Cell Biology and Metabolism
• 414 Molecular Medicine
• 491 Human Genetics Seminar
• 497 Tutoring in Biological Chemistry
• 498 Group Study
• 499 Research

Current Lab Members

• Dr. Ying Tan
• Dr. Chien-Wei Huang
• MS. Wen-Hui Chiang

Previous Lab Members

• Dr. Chun-Lung (Jason) Chiu
• Dr. Gauri Khandekar
• Dr. Ngoc-Uyen-Nhi Nguyen
• Dr. Irene (Yi-Ping) Shih
• Dr. Minmin Song
• Dr. Zong Ye Wu
• Dr. Arron Bruns
• Dr. Shiao-Ya Hong
• Dr. Peng Sun
• Dr. Aifeng Wang