Aiming Yu, Ph.D.
Oak Park Research Building
2700 Stockton Blvd.
Sacramento, CA 96817
Dr. Yu’s research interests include noncoding microRNA pharmacoepigenetics and cancer therapy. The ultimate goal of his research is to translate noncoding RNAs to new therapeutics. Current efforts in his laboratory are directed to the investigation of (a) the mechanistic actions of microRNAs in the regulation of cancer cellular processes including drug/xenobiotic disposition and tumor progression, (b) novel RNA bioengineering technology, and (C) recombinant RNAs for research and therapy.
Dr. Yu also directs the PK/PD Bioanalytical Core Facility that provides services in support of the clinical and preclinical drug development programs, and the Molecular Pharmacology Shared Resources that supports high-quality collection, processing and analysis of clinical specimens and conducts preclinical modeling and evaluation of novel anticancer agents or combination.
Yu AM, Jian C, Yu AH, Tu MJ. RNA Therapy: Are we using the right molecules? Pharmacol Ther. (Epub ahead of print).
Tu MJ, Ho PY, Zhang QY, Jian C, Qiu JX, Kim EJ, Bold RJ, Gonzalez FJ, Bi H, Yu AM. Bioengineered miRNA-1291 prodrug therapy in pancreatic cancer cells and patient-derived xenograft mouse models. Cancer Lett. 442:82-90 (2019).
Zhang QY, Ho PH, Tu MJ, Jilek JL, Chen QX, Zeng S, Yu AM. Lipidation of polyethylenimine-based polyplex increases serum stability of bioengineered RNAi agents and offers more consistent tumoral gene knockdown in vivo. J. Pharm. 547(1-2):537-544 (2018).
Ho PH, Duan Z, Batra N, Jilek JL, Tu MJ, Qiu JX, H Z, Wun T, Lara PN, DeVere White RW, Chen HW, Yu AM. Noncoding RNA carrier (nCAR) enables high-success-rate, high-yield production of target RNAi agents in bacterial fermentation to modulate human cell transcriptome. Pharmacol. Exp. Ther. 365(3):494-506 (2018).
Jian C, Tu MJ, Ho PY, Duan Z, Zhang Q, Qiu JX, DeVere White R, Wun T, Lara PN, Lam KS, Yu AX, Yu AM. Co-targeting of DNA, RNA, and protein molecules provides optimal outcomes for treating osteosarcoma and pulmonary metastasis in spontaneous and experimental metastasis mouse models. Oncotarget. 8(19):30742-30755 (2017).
Jilek JL, Tian Y and Yu AM. Effects of MicroRNA-34a on the Pharmacokinetics of Cytochrome P450 Probe Drugs in Mice. Drug Metab Dispos. 45(5):512-522 (2017).
Tu MJ, Pan YZ, Qiu JX, Kim E, Yu AM. MicroRNA-1291 targets the FOXA2-AGR2 pathway to suppress pancreatic cancer cell proliferation and tumorigenesis. Oncotarget. 7(29):45547-45561 (2016).
Zhao Y, Tu MJ, Wang WP, Qiu JX, Yu AX, Yu AM. Genetically engineered miR-34a prodrug suppresses orthotopic osteosarcoma tumor growth via the induction of apoptosis and cell cycle arrest. Sci Rep. 6:26611 (2016).
Wang WP, Ho PY, Li MM, Chen QX, Addepalli B, Tu MJ, Limbach PA, Li MM, Wu WJ, Jilek JL, Qiu JX, Zhang HJ, Li T, Wun T, DeVere White R, Lam KS, Yu AM. Bioengineering novel chimeric microRNA-34a for prodrug cancer therapy: High-yield expression and purification, and structural and functional characterization. Pharmacol. Exp. Ther. 354(2):131-141 (2015).
Chen QX, Wang WP, Zeng S, Uroyama S, Yu AM. A general approach to high-yield biosynthesis of chimeric RNAs bearing various types of functional small RNAs for broad applications. Nucleic Acids Res, 43(7):3857-3869 (2015).
Li MM, Wang WP, Wu WJ, Huang M, and Yu AM. Rapid production of novel pre-microRNA agent hsa-mir-27b in Escherichia coli using recombinant RNA technology for functional studies in mammalian cells. Drug Metab Dispos. 42(11):1791-1795 (2014).
Bi HC, Pan YZ, Qiu JX, Krausz KW, Li F, Johnson CH, Jiang CT, Gonzalez FJ, and Yu AM. N-methylnicotinamide and nicotinamide N-methyltransferase are associated with microRNA-1291 altered pancreatic carcinoma cell metabolome and suppressed tumorigenesis. Carcinogenesis, 35(10):2264-2272 (2014).
See other publications on PubMed ».
- PTX201 Principles of Pharmacology and Toxicology I
- VMB253 Drug Metabolism and Disposition
- BCB299 Research
- PTX299 Research