Assistant Professor, Department of Pediatrics, Division of Genomic Medicine and Department of Physiology and Membrane Biology
To see if Daniah Thompson Beleford is accepting new patients, or for assistance finding a UC Davis doctor, please call 800-2-UCDAVIS (800-282-3284).
Rare genetic conditions have profound impacts on patients and their families. Dr. Beleford's philosophy of care is that the needs of the patient come first. Dr. Beleford strives to help patients and their families make informed medical decisions about their care, including decisions about pursuing genetic testing, based on their unique needs and desired outcomes.
Dr. Beleford is a clinical geneticist and physician scientist who provides care for children, adults, and families with rare, complex genetic disorders including chromosome disorders, single-gene disorders, and multifactorial disorders with complex inheritance. She has a special clinical interest in vascular anomalies - conditions that cause arterial, venous, and lymphatic malformations. She is also interested in rare genetic conditions that occur in adults and in disorders of sexual development in adults.
Dr. Beleford's research program within the Department of Pediatrics and Department of Physiology and Membrane Biology studies the molecular genetic causes of vascular anomalies - disorders of arterial, venous, and lymphatic development. Dr. Beleford's group is interested in genetic modifiers of rare vascular conditions such as Hereditary Hemorrhagic Telangiectasia and in clarifying molecular signals and interactions that cause vascular disease. The lab utilizes mouse disease modeling and basic molecular biology techniques.
B.A., Genetics and Development, Cornell University, Ithaca NY 1996
M.D., Mayo Clinic College of Medicine Medical Scientist Training Program (MSTP), Rochester MN 2014
Ph.D, Biochemistry and Molecular Biology, Mayo Clinic College of Medicine Medical Scientist Training Program (MSTP), Rochester MN 2013
Internal Medicine, University of Minnesota, Minneapolis MN 2013-2016
Medical Genetics and Genomics, UC an Francisco School of Medicine, San Francisco CA 2016-2018
Medical Genetics and Genomics, UC San Francisco School of Medicine, San Francisco CA 2018-2019
NIH T32 Postdoctoral Fellow/Lung Biology, UC San Francisco School of Medicine, San Francisco CA 2018-2019
UC President's Postdoctoral Research Fellowship/Vascular Biology, UC San Francisco School of Medicine, San Francisco CA 2021-2023
NIH Training Grant T32, UCSF Lung Biology Program 2018-,, 2019
NIH Diversity Supplement to NCI Award R01CA210561 2019-,, 2021
Travel Award, Poster presentation at the 22nd International Vascular Biology Meeting, Oakland, California, 2022
UC President’s Postdoctoral Fellowship, University of California, San Francisco 2021-,, 2023
Thompson, DA, Cormier, EG, Dragic, T (2002). CCR5 and CXCR4 Usage by Non Clade B Human Immunodeficiency Virus Type 1 Primary Isolates. Journal of Virology March; 76(6): 3059-3064. PMID: 11861874.
Beleford, D, Liu, Z, Rattan, R, Quagliuolo, L, Boccellino, M, Baldi, A, Maguire, J, Staub, J, Molina, J, Shridhar, V (2010). Methylation-induced gene silencing of HtrA3 in smoking-related lung cancer. Clini-cal Cancer Research January 15;16(2):398-409. PMID: 20068077.
Beleford, D, Rattan, R, Chien, J, Shridhar, V (2010). High-temperature requirement A3 (HtrA3) pro-motes etoposide- and cisplatin-induced cytotoxicity in lung cancer cell lines. Journal of Biological Chem-istry April 16;285(16):12011-12027. PMID: 20154083.
Beleford, D and Shridhar, V. (2013). HtrA3 Peptidase. In Handbook of Proteolytic Enzymes (Vol. 3, pp. 2584-2590). Elsevier Ltd. https://doi.org/10.1016/B978-0-12-382219-2.00572-X
Kumar A, Zastrow DB, Kravets EJ, Beleford D, Ruzhnikov MRZ, Grove ME, Dries AM, Kohler JN, Waggott DM, Yang Y, Huang Y; Undiagnosed Diseases Network, Mackenzie KM, Eng CM, Fisher PG, Ashley EA, Teng JM, Stevenson DA, Shieh JT, Wheeler MT, Bernstein JA. Extracutaneous Manifesta-tions in Phacomatosis Cesioflammea and Cesiomarmorata: Case Series and Literature Review (2019) American Journal of Medical Genetics A, Jun;179(6):966-977. PMID: 30920161.
Beleford, DT, Diab, M, Qubty, WF, Malloy, MJ, Long, RK, Shieh, JT. Schimke Immunoosseous Dys-plasia and Management Considerations for Vascular Risks (2019). American Journal of Medical Genetics A, Jul;179(7):1246-1252. PMID: 31039288.
Ha, TK, Mardy, AH, Beleford, D, Spanier, A, Wayman, BV, Penon-Portman, M, Wiita, AP, Shieh, JT. Characterization of a Novel X-Linked Copy Number Variation Associated with Overgrowth (2019) American Journal of Medical Genetics C Semin Med Genet, Dec;181(4):644-64. PMID: 31762227.
Mendelsohn*, B, Beleford*, D, Abu-El-Haija, A, Alsaleh, N, Rahbeeni, Z, Martin, PM, Rego, S, Huang, A, Capodanno, G, Shieh, JT, Van Ziffle, J, Risch, N, Alkuraya, F, Slavotinek, A. *Authors contributed equally. (2020) A novel truncating variant in ring finger protein A (RNF113A) confirms the association of this gene with X-linked trichothiodystrophy. American Journal of Medical Genetics A, Mar;182(3):513-520. PMID: 31880405.
Beleford, DT, Van Ziffle, J, Hodoglugil, U, Slavotinek, A (2020). A missense variant, p.(Ile269Asn), in MC4R as a secondary finding in a child with BCL11A-related intellectual disability. European Journal of Medical Genetics Jun 10; 103969. PMID: 32534219.
Shieh*, JT, Penon-Portmann*, M, Wong*, KHY, Levy-Sakin, M, Verghese, M, Slavotinek, A, Gallagher, R, Mendelsohn, B, Tenney, J, Beleford, D, Perry, H, Chow, SK, Sharo, A, Qi, Z, Yu, J, Klein, O, Mar-tin, P, Kwok, PY, Boffelli, D. *Authors contributed equally (2021). Application of Full Genome Analysis to Diagnose Rare Monogenic Disorders. NPJ Genomic Medicine. 2021 Sep 23;6(1):77.