April 2017 - Presented by Dr. Guofeng Gao & Dr. Regina Gandour-Edwards

Clinical History

A 74-year-old man has a 1.5 year history of a right inferior pole renal mass seen incidentally on CT scan. He has been asymptomatic and under observation with imaging studies. Surveillance CT revealed a slight increase in mass size from 1.8 cm to 2.2 cm. PET/CT scan demonstrated a FDG avid lesion. He is referred for biopsy and radiofrequency ablation of this right renal mass.

Microscopic Description

The CT guided core biopsy showed bland and uniform, oval or spindle cells arranged in parallel bundles, cuboidal cells in tightly packed tubules, and prominent vacuoles in a myxoid/mucinous stroma (Figure 1 and 2). The nuclei are round and uniform with evenly dispersed chromatin and prominent small single nucleoli. Mitoses are rare and no necrosis is present. IHC results: Tumor cells were Positive for CK7 (Figure 3), AMACR (Figure 4), RCC (Figure 5), PAX8 (Figure 6) and PAX2 (Figure 7); and Negative for CD10 (Figure 8).

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Figure 1 Figure 2 Figure 3
Figure 4 Figure 5 Figure 6
Figure 7 Figure 8



What is the diagnosis?

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The correct answer is

E. Mucinous Tubular and Spindle Renal Cell Carcinoma (the name in the CAP protocol)

> Learn more about this diagnosis.