Resident Program - Case of the Month

Clinical History

Patient is a 71-year-old woman with persistent lower left quadrant pain and a CT scan that showed a solid 4 cm right ovarian mass.  No extraovarian masses, ascites, or pleural effusion were noted.  Family history was concerning for multiple relatives with breast cancer and a daughter who died in her early 30s from metastatic colon cancer.

Pathology Review:

Gross examination showed a circumscribed, ovoid, firm, rubbery yellow-tan mass with a pale-tan cut surface (3.9 x 2.6 x 1.4 cm) in the right ovary, which was submitted for frozen section analysis.  Microscopic examination revealed a hypocellular spindle cell tumor growing in storiform and fascicular patterns.  The cells contained bland, ovoid, tapered fusiform nuclei with eosinophilic cytoplasm that blended with a variable amounts of extracellular collagen.  A diagnosis of fibroma was rendered.  The patient underwent bilateral salpingo-oophorectomy; the contralateral ovary contained a similar mass (1.7 x 1.7 x 1.3 cm).  No calcifications were observed in either ovarian mass.

Images:

(Click image to enlarge)

Figure 1: Right ovarian mass and fallopian tube

Figure 2: Left ovarian mass and multicystic ovarian parenchyma

Figure 3: Ovarian fibroma, 4x

Figure 4: Ovarian fibroma, 10x

Figure 5: Ovarian fibroma, 40x

What syndrome is most often associated with bilateral fibromas?

Choose one answer and submit.