September 2019 - Presented by Dr. Miao Tian (Mentored by Dr. Karen Matsukuma)

Clinical History

A 65-year-old man presented with one week of non-radiating right lower quadrant abdominal pain associated with nausea, vomiting, and anorexia. CT on admission showed acute non-perforated appendicitis.  He was subsequently taken to the OR for laparoscopic appendectomy. Intraoperatively he was found to have perforated appendicitis with murky, purulent fluid throughout the abdomen.

Histology

Figure 1.

Figure 2.

Figure 3.

Figure 4. CDX2

Figure 5. Synaptophysin

What is most likely the diagnosis?

Choose one answer and submit.




Low-grade appendiceal goblet cell adenocarcinoma
High-grade appendiceal goblet cell adenocarcinoma

 

The correct answer is:

D.) Low-grade appendiceal goblet cell adenocarcinoma

Low-grade appendiceal goblet cell adenocarcinoma (LG-GCAC) (formerly typical goblet cell carcinoid) is a mixed endocrine-exocrine neoplasm almost exclusively seen in the appendix.

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