December 2023 | Case of the Month for Residency Program

A 52-year-old, postmenopausal G1P1 female with a family history of breast carcinoma presents for routine mammogram and is found to have multiple left breast lesions. Menarche was at 14 years old. Imaging finds a 1.6 x 1.6 cm high density, partially circumscribed mass with microcalcifications located at 3:00, 6cm posterior to the nipple and a 1.4 cm mass at 12:00, 9cm posterior to the nipple line. Core needle biopsy is shown below. What is the most likely diagnosis?

H&E

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A.) Atypical lobular hyperplasia (ALH)

B.) Ductal carcinoma in situ (DCIS)

C.) Lobular carcinoma in situ (LCIS)

D.) Usual ductal hyperplasia (UDH)

E.) Invasive lobular carcinoma (ILC)

E-Cadherin

A.) Atypical lobular hyperplasia (ALH)

B.) Ductal carcinoma in situ (DCIS)

C.) Lobular carcinoma in situ (LCIS)

D.) Usual ductal hyperplasia (UDH)

E.) Invasive lobular carcinoma (ILC)