James Littlejohn, M.D., Ph.D.

James Eliot Littlejohn, M.D., Ph.D.



Critical Care Medicine


  • Assistant Clinical Professor
James Eliot Littlejohn is not currently accepting new patients. For assistance finding a UC Davis doctor, please call 800-2-UCDAVIS (800-282-3284).

Patient Support Services Building

4150 V St., Suite 1200
Sacramento, CA 95817
Driving Directions

Primary Phone:

Additional Phone Numbers

Department Fax: 916-734-7980

Research/Academic Interests

Dr. Littlejohn's research interests include: Acquired Coagulopathies and Hemorrhagic Shock.


General Anesthesiology

Center/Program Affiliation

Trauma Program


M.D., Ph.D., Texas A&M University College of Medicine, Bryan TX 2010

B.A., UC Berkeley, Berkeley CA 2002


Anesthesiology, New York Presbyterian Hospital - Weill Cornell Medical Center, New York NY 2011-2014


Critical Care Medicine, University of Pennsylvania Medical Center, Philadelphia PA 2014-2015

Board Certifications

American Board of Anesthesiology, 2015

American Board of Anesthesiology - Critical Care Medicine, 2015

Professional Memberships

American Medical Association

American Society of Anesthesiologists and California Society of Anesthesiologists

California Medical Association

Society of Critical Care Anesthesiology

Society of Critical Care Medicine

Honors and Awards

Keynote Speaker, Anesthesiology Resident and Fellows Graduation, Department of Anesthesiology and Pain Medicine, UC Davis Medical Center, Walter Buehler Alumni Center, Davis, CA, 2016

Outstanding Teacher of the Year, Department of Anesthesiology and Pain Medicine, UC Davis Medical Center, 2015

New York Presbyterian-Weill Cornell Medical Center: Translation Research Grant ($50,000) for "Utility of Fibrinogen Concentrate vs. Cryoprecipitate in Bleeding Cardiovascular Surgery Patients Exhibiting Hypofibrinogenemia", 2014

Joseph F. Atrusio Outstanding Resident Award, , Department of Anesthesia Weill Cornell Medical Center, 2014

American-Austria Foundation Fellow, Perioperative Bleeding Seminar, 2013

Weill-Cornell Department of Anesthesiology- Chief Resident, 2013

Select Recent Publications

Raiten JM, Wong ZZ, Spelde A, Littlejohn JE, Augoustides JGT, and Gutsche JT. Anticoagulation and Transfusion Therapy in Patients Requiring Extracorporeal Membrane Oxygenation. Journal of Cardiothoracic and Vascular Anesthesia. 2017;31(3): 1051-1059.

Rascoe PA,Jupiter D, Cao X, Littlejohn JE, Smythe WR. Molecular pathogenesis of malignant mesothelioma. Expert Reviews in Molecular Medicine. 2012;14(e12): 1-14.

Zhang L, Littlejohn JE, Cui Y, Cao X, Peddabonia C, Smythe WR. Characterization of bortezomib-adapted I-45 mesothelioma cells, Molecular Cancer. 2010 May 18; 9:110.

Cao, X., Littlejohn, J.E., Zhang, L., Martino, B., Rascoe, P., Rodarte, C., Smythe, WR. The Upregulation of Bcl-xL by Hepatocyte Growth Factor in Human Mesothelioma Cells Involves ETS Transcription Factors. Am J of Pathology, 2009;175(5):2201-2211.

Littlejohn, J.E., Cao, X., Miller, S.D., Ozvaran M.K., Jupiter, D., Zhang, L., Rodarte, C., Smythe W.R. BclxL antisense oligonucleotide and cisplatin combination therapy extends survival in SCID mice with established mesothelioma xenografts. International J of Cancer, 2008;123(1): 202-8.

Bumbaca, D., Littlejohn, J.E., Nayakanti, H., Lucas, A.H., Rigden, D.J., Galperin, M.Y., Jedrzejas, M.J. Genome based identification and characterization of a putative mucin-binding protein from the surface of Streptococcus pneumoniae. Proteins-Structure Function and Bioinformatics, 2007;66 (3): 547-558.

Cao, X., Rodarte,C., Zhang,L., Morgan,C.D., Littlejohn, J., and Smythe,W.R. Bcl2/bcl-x(L) Inhibitor Engenders Apoptosis and Increases Chemosensitivity in Mesothelioma. Cancer Biology and Therapy, 2007;6:246-252.

Nukui, M., Mello, L.V., Littlejohn, J.E., Setlow, B., Setlow, P., Kim, K., Leighton, T., Jedrzejas, M.J. Structure and molecular mechanism of Bacillus anthrasis cofactor-independent phosphoglycerate mutase: A crucial enzyme for spores and growing cells of Bacillus species. Biophysical Journal, 2007;92 (3): 977-988.

Rigden, D.J., Littlejohn, J.E., Joshi, H.V., de Groot, B.L., Jedrzejas, M.J. Alternate Structural Conformations of Streptococcus pneumoniae Hyaluronan Lyase: Insights into the Enzyme Flexibility and Underlying Molecular Mechanism of Action. J of Molecular Biology, 2006;358 (4): 1165-1178.

Bumbaca, D., Littlejohn, J.E., Nayakanti, H., Rigden, D.J., Galperin, M.Y., Jedrzejas, M.J. Sequence analysis and characterization of a novel fibronectin-binding repeat domain from the surface of Streptococcus pneumoniae. OMICS Winter, 2004;8(4):341-56.