Browse
All Articles
Cancer

Introduction to Molecular Pathways & Routine DNA MMR Deficiency Testing in Colorectal Adenocarcinoma

Colorectal cancer is the third most common cause of cancer death in both men and women in the United States [1]. The vast majority of colorectal cancers are adenocarcinomas, which are malignancies arising from the

Read More
Coronavirus

Debunking Common Misconceptions of COVID-19 Related Testing and Transfusion Practices

The 2019 novel coronavirus infectious disease (COVID-19) pandemic resulted in a constant and massive surge of information. Over 100,000 scientific articles related to COVID-19 were published in 2020 alone.

Read More

Flow Cytometric Immunophenotypic Analysis of Hematolymphoid Neoplasms

Flow cytometry (FCM) by immunophenotypic analysis has a prominent role in the diagnosis and classification of hematolymphoid neoplasms, and in monitoring response to therapy. There have been tremendous advances for

Read More

Reconstituted Whole Blood Transfusion Exchange in Neonatal Hyperbilirubinemia

The blood bank occasionally will receive requests for a transfusion exchange in a neonate with hyperbilirubinemia. Neonates with hyperbilirubinemia may necessitate hospital admissions with approximately 5-10% of all

Read More
Infectious Diseases

Comparison of SARS-CoV-2 Specimen Types: Nasal Swabs, Nasopharyngeal Swabs and Beyond

The nasopharyngeal (NP) swab serves as the primary specimen type for respiratory molecular pathogen detection. During the novel coronavirus infectious disease (COVID) pandemic of 2019, the NP swab became the

Read More
Coronavirus

Role of Quantitative Serology Testing for COVID-19

The current pandemic has led to considerable interest in COVID-19 related laboratory testing. The widespread distribution of the various vaccines, the emerging genetic variants of SARS-CoV-2 circulating around the

Read More

An Overview of Prosthetic Joint Infection (PJI) Definition and Diagnosis

The numbers of primary total hip and knee arthroplasties have been increasing over time, with 332,000 total hip and 719,000 total knee arthroplasties performed in 2010 in the United States.

Read More
Infectious Diseases

Hepatitis B Serologic Testing Methods

Hepatitis B virus (HBV) was first discovered in 1965. Briefly, HBV is a DNA virus from the Hepadnaviridae family which is spread via contaminated body fluids. After exposure, the virus enters hepatocytes and .....

Read More

Plasma Exchange with Albumin Replacement for Alzheimer’s Disease

The guidelines on the use of therapeutic Apheresis in clinical practice published in JCP 2019 has showed strong consideration for the addition of a new fact sheet on Alzheimer’s disease (AD) based on the ....

Read More

Fine Needle Aspiration (FNA)

FNA is a simple, safe, and Cost-effective procedure for patient with a mass. FNA is a biopsy procedure and should be considered in the same light as a surgical biopsy.

Read More

Race and eGFR: Addressing Health Disparities in Chronic Kidney Disease

Starting on May 4, 2021, UC Davis Health will calculate estimated glomerular filtration (eGFR) rate without a parameter for race. African Americans are at high risk for chronic kidney disease (CKD).

Read More
Infectious Diseases

Acid Fast Bacilli (AFB) Smear and Culture Testing

It is a foundational principle for any laboratory test procedure that the value of the test heavily relies on using specimens that have been properly collected, labelled, handled or stored prior to....

Read More

The Importance of Trephine Biopsy and Aspirate in Bone Marrow Analysis

The morphologic analysis of bone marrow specimen is an essential part of comprehensive evaluation in the diagnosis of hematologic and certain non-hematologic disorders.

Read More
Coronavirus

The SARS-CoV-2 Variant and its Impact on Diagnostic Testing

The new SARS-CoV-2 mutant (VOC 202012/01) has become the dominant variant in the United Kingdom (UK) with the first known case in the United States identified on December 29, 2020.

Read More