Anupam Mitra, M.B.B.S., M.D.

GI/ Liver Fellow, PGY-5

Medical School:

R.G. Kar Medical College, Kolkata, India

Personal Interests:
Traveling, playing and watching cricket, photography, following global news

Reason for selecting UC Davis for Residency:
I felt the friendly atmosphere with supportive residents and faculty when I visited for interview. On top of that, it is a major academic center with the opportunity to see good number of cases as well complex cases, great location in northern California- access to nature and big cities, and affordable living.

Clinical Interests

• Transfusion Medicine
• Dermatopathology
• GI Pathology
• Molecular Genetics

Research Interests

• Identify novel molecular target(s) in different cancers
• Develop and validate new point-of-care testing
• CART cell therapy in cancers/autoimmune diseases

CV Highlights/Brief Biography:

Anupam grew up in a big city (Kolkata) in India and finished his graduate medical education from R.G. Kar Medical College and Hospital, the first non-governmental medical college established in Asia (1886). After M.B.B.S., he did a specialization (equivalent to fellowship) in clinical pharmacology (M.D.) and worked as a co-investigator in several phase III clinical trials in diabetes. To better understand the pathogenesis of human autoimmune skin and joint diseases, after finishing M.D. he joined UC Davis as a postdoctoral fellow and worked for few years before joining residency. His translational research work established the pathological role of IL-22 and mTOR signaling pathway in psoriatic disease, rheumatoid arthritis and scleroderma.

Publications, Abstracts and/or Posters

• Mitra A, Dwyre DM, Schivo M, Thompson GR 3rd, Cohen SH, Ku N, Graff JP. "Leukoerythroblastic reaction in a patient with COVID-19 infection". Am J Hematol. 2020 Mar 25. doi: 10.1002/ajh.25793. 
• Holland L, Wei D, Olson KA, Mitra A, Graff JP et al. "Effect of training set size on deep learning classification accuracy, a proof of concept of machine learning models for colon histology". Journal of Pathology Informatics. 2020 Feb 21;11:5. doi: 10.4103/jpi.jpi_49_19. eCollection 2020.
• Raychaudhuri SK, Abria C, Mitra A, Raychaudhuri SP. "Functional significance of MAIT cells in psoriatic arthritis". Cytokine. 2020 Jan;125:154855. doi: 10.1016/j.cyto.2019.154855. Epub 2019 Sep 18.
• Mitra A, Ghosh RK, Bandyopadhyay D, Ghosh GC, Kalra A, Lavie CJ. "Significance of Pulmonary Hypertension in Hypertrophic Cardiomyopathy". Curr Probl Cardiol. 2018 Oct 17. pii: S0146-2806(18)30157-9. doi: 10.1016/j.cpcardiol.2018.10.002.
• Mitra A, Tripathi S, Bhattacharya G, Majumder P. "Somnambulism associated with the use of clonidine: A case report and review of the literature". Indian J Psychiatry. 2018 Jul-Sep;60(3):372-373. doi: 10.4103/psychiatry.IndianJPsychiatry_463_17.
• Mitra A, Datta Mitra A, Graff JP. "A 42-year old woman with a cervical mass: a rare diagnosis to decipher". American Society for Clinical Pathology Case Reports.
• Mitra A, Kundu-Raychaudhuri S, Abria C, et al. "In vivo quantitative assessment of the therapeutic response in a mouse model of collagen induced arthritis using 18F-fluorodeoxyglucose positron emission tomography". Clin Exp Immunol. 2017 Jan 16. doi: 10.1111/cei.12926. Epub 2017 Feb 24.
• Mitra A, Luna JI, Marusina AI, et al. "Dual mTOR Inhibition is Required to Prevent TGF-β-Mediated Fibrosis: Implications for Scleroderma". J Invest Dermatol. 2015 Jul 2. doi: 10.1038/jid.2015.252.
• Datta-Mitra A*, Mitra A* (*joint first author), Ray R, Raychaudhuri SP, Kundu-Raychaudhuri S. "1,25-Dihydroxyvitamin D3-3-bromoacetate, a novel vitamin D analog induces immunosuppression through PI3K/Akt/mTOR signaling cascade". Int Immunopharmacol. 2013 Nov;17(3):744-51.
• Mitra A, Raychaudhuri SK, Raychaudhuri SP. "IL-22 induced cell proliferation is regulated by PI3K/Akt/mTOR signaling cascade". Cytokine. 2012 Oct;60(1):38-42.
• Mitra A, Fallen RS, Lima HC. "Cytokine-based therapy in psoriasis". Clin Rev Allergy Immunol. 2013 Apr;44(2):173-82.
• Mitra A, Raychaudhuri SK, Raychaudhuri SP. "Functional role of IL-22 in psoriatic arthritis". Arthritis Res Ther. 2012 Mar 14;14(2): R65.
• Wang EA, Steel A, Luxardi G, Mitra A et al. "Classic Ulcerative Pyoderma Gangrenosum Is a T Cell-Mediated Disease Targeting Follicular Adnexal Structures: A Hypothesis Based on Molecular and Clinicopathologic Studies". Front Immunol. 2018 Jan 15;8: 1980. doi: 10.3389/fimmu.2017.01980.
• Bustos-Villalobos I, Bergstrom JW, Haigh NE, Luna JI, Mitra A, et al. "ITK inhibition for the targeted treatment of CTCL". J Dermatol Sci. 2017 Jul; 87(1):88-91. doi: 10.1016/j.jdermsci.2017.04.001.
• Park D, Arabyan N, Williams CC, Song T, Mitra A, et al. "Salmonella Typhimurium Enzymatically Landscapes the Host Intestinal Epithelial Cell (IEC) Surface Glycome to Increase Invasion". Mol Cell Proteomics. 2016 Dec;15(12):3653-3664.
• Safra N, Hitchens PL, Maverakis E, Mitra A, et al. "Serum levels of innate immunity cytokines are elevated in dogs with metaphyseal osteopathy (hypertrophic osteodytrophy) during active disease and remission". Vet Immunol Immunopathol. 2016 Oct 15; 179:32-5. doi: 10.1016/j.vetimm.2016.08.003.
• Tran KA, Cheng MY, Mitra A, et al. "MEK inhibitors and their potential in the treatment of advanced melanoma: the advantages of combination therapy". Drug Des Devel Ther. 2015 Dec 21; 10:43-52. doi: 10.2147/DDDT.S93545.
• Park D, Brune KA, Mitra A, et al. "Characteristic Changes in Cell Surface Glycosylation Accompany Intestinal Epithelial Cell (IEC) Differentiation: High Mannose Structures Dominate the Cell Surface Glycome of Undifferentiated Enterocytes". Mol Cell Proteomics. 2015 Nov;14(11):2910-21. doi: 10.1074/mcp.M115.053983.
• He Y, Shimoda M, Ono Y, Villalobos IB, Mitra A, et. al. "Persistence of Autoreactive IgA-Secreting B Cells Despite Multiple Immunosuppressive Medications Including Rituximab". JAMA Dermatol. 2015 Apr 22. doi: 10.1001/jamadermatol.2015.59.
• Datta-Mitra A, Kundu-Raychaudhuri S, Mitra A, et al. "Cross Talk between Neuroregulatory Molecule and Monocyte: Nerve Growth Factor Activates the Inflammasome". Plos One. 2015 Apr 15;10(4): e0121626. doi: 10.1371/journal.pone.0121626.
• Kundu-Raychaudhuri S, Mitra A, Datta-Mitra A, et al. "In vivo quantification of mouse autoimmune arthritis by PET/CT". Int J Rheum Dis. 2014 Jun 26.
• Raychaudhuri S, Mitra A, Datta Mitra A. "Immunomodulatory Mechanisms of Action of Calcitriol in Psoriasis". Indian J Dermatol. 2014 Mar;59(2):116-22.
• Mitra AD, Raychaudhuri SP, Abria CJ, Mitra A et al. "1α,25-Dihydroxyvitamin-D3-3-Bromoacetate Regulates AKT/mTOR Signaling Cascades: A Therapeutic Agent for Psoriasis". J Invest Dermatol. 2013 Jun;133(6):1556-64.
• Raychaudhuri SP, Mitra A. "Polymyositis and dermatomyositis: Disease spectrum and classification". Indian J Dermatol. 2012 Sep;57(5):366-70.
• Siegel D, Devaraj S, Mitra A et al. "Inflammation, atherosclerosis, and psoriasis". Clin Rev Allergy Immunol. 2013 Apr;44(2):194-204.
• Kundu S, Bala A, Ghosh P, Mukhopadhyay D, Mitra A et al. "Attenuation of oxidative stress by allylpyrocatechol in synovial cellular infiltrate of patients with Rheumatoid Arthritis". Free Radic Res. 2011 May;45(5):518-26.
• Chatterjee S, Biswas T, Dutta A, Sengupta G, Mitra A, et al. "Clinical effectiveness and safety of gemifloxacin versus cefpodoxime in acute exacerbation of chronic bronchitis: A randomized, controlled trial". Indian J Pharmacol. 2011 Feb;43(1):40-4.

Book Chapters

• Datta Mitra A and Mitra A. "Clinical Presentation of Psoriasis". In Psoriasis - Types, Causes and Medication. Edited by: Lima H. 2013. ISBN 978-953-51-1065-1. InTech, Croatia
• Fallen RS, Mitra A, Morrisey L and Lima H. "Treatment of Psoriasis with Topical Agents". In Psoriasis - Types, Causes and Medication. Edited by: Lima H. 2013. ISBN 978-953-51-1065-1. InTech, Croatia
• Fallen RS, Mitra A, Morrisey L and Lima H. "Psoriasis at Chess Board — An Update of Psoriasis Pathophysiology". In Psoriasis - Types, Causes and Medication. Edited by: Lima H. 2013. ISBN 978-953-51-1065-1. InTech, Croatia
• Mitra A, Raychaudhuri SK and Raychaudhuri SP. "NGF and Its Receptor System in Inflammatory Diseases". In Chronic Inflammation: Molecular Pathophysiology, Nutritional and therapeutic Interventions. Edited by: Roy S, Bagchi D & Raychaudhuri SP. CRC press, Taylor & Francis Group, New York. 2013. ISBN: 978-1-4398-7211-6.

Link to PubMed:

• https://www.ncbi.nlm.nih.gov/pubmed/?term=anupam+Mitra