Shehnaz Khursheed Hussain, Ph.D., Sc.M.

Professor

Reviews

Specialties

Liver Cancer Surgery

Cancer

Clinical Research

Nutrition

Immunology

Locations and Contact

Additional Numbers

Physician Referrals

800-4-UCDAVIS (800-482-3284)

Research/Academic Interests

Dr. Hussain's research stems from a long-standing interest in the intersection of infections and cancer. As a molecular epidemiologist, she brings together a mindset for maximizing public health impact and scientific curiosity to orchestrate research in cancer etiology, pathogenesis, chemoprevention, and early detection. A common thread of her ongoing research is the identification of biomarkers that relate to, or modulate, the immune response including serum immune markers, intestinal microbiome, and immunogenic microbial components and metabolites.

Currently, she is utilizing this immunoepidemiology lens to lead investigations of the disease continuum from metabolic associated fatty liver disease to liver cancer. Key components of this integrated research program include nutritional interventions in fatty liver, novel biomarker identification for the progression of cirrhosis to HCC, and statin interventions in cirrhosis and HCC. Additionally, her work explores potential biological basis for disparities in liver cancer which disproportionately affects Latinx/Hispanic individuals.

Lastly, aligned with her long-standing interests in infectious causes of cancer, she is actively conducting research on EBV- and HPV-associated cancer etiology and prevention, particularly in the setting of severe immunosuppression (HIV and solid organ transplantation). 

Division

Public Health Sciences

Center/Program Affiliation

UC Davis Comprehensive Cancer Center

Undergraduate School

B.A., Colorado College, Colorado Springs CO 1999

Other School

Sc.M., Epidemiology, Johns Hopkins University, Baltimore MD 2002

Other School

Ph.D., Epidemiology, University of Washington, Seattle, Seattle WA 2006

Fellowship

Cancer Epidemiology, Karolinska Institute, Stockholm, Sweden 2006-2007

Fellowship

Cancer Prevention, Division of Cancer Prevention & Control Research, UCLA, Los Angeles CA 2007-2008

Plenary Speaker, Colorado College Biology Day, 2012

Award Recipient at Fashion for the Cure, Susan G. Komen, Los Angeles Chapter, Recognition of Research, 2008

Selected Participant, American Association for Cancer Research (AACR) and National Cancer Institute, Pathobiology of Cancer Workshop, Aspen CO, 2008

Selected Participant, American Society for Preventive Oncology (ASPO) New Investigator Workshop, Bethesda MD, 2008

R25 Career Development Post-Doctoral Fellowship in Cancer Prevention and Control Research (R25 CA 87949), School of Public Health, UCLA, 2007, 2008

Scholar-in-Training Award, Molecular Epidemiology Working Group (MEG) of the American Association for Cancer Research (AACR), Anaheim CA, 2005

Selected Participant, Society for Epidemiologic Research (SER) Student Workshop on Epidemiological Methods, Salt Lake City UT, 2004

R25 Cancer Prevention Training Pre-Doctoral Fellowship (R25 CA 094880), School of Public Health and Community Medicine, University of Washington, Seattle WA, 2002, 2003, 2004, 2005, 2006

Carol Eliasberg Martin Scholarship in Cancer Prevention, Johns Hopkins Bloomberg School of Public Health, Baltimore MD, 2002

Special Training Award, International Agency for Research on Cancer (IARC), Lyon (France), 2001

Complete List of Published Work in MyBibliography:

http://www.ncbi.nlm.nih.gov/sites/myncbi/shehnaz.hussain.1/bibliograpahy/42203900/public/?sort=date&direction=ascending

Benhammou JN, Aby EE, Shirvanian G, Manansala K, Hussain SK, Tong MJ. Improved survival after treatments of patients with nonalcoholic fatty liver disease associated hepatocellular carcinoma. Sci Rep. 2020 Jun;10(1). doi:10.1038/s41598-020-66507-7.

Hussain SK, Dong TS, Agopian V, Pisegna JR, Durazo FA, Enayati P, Sundaram V, Benhammou JN, Noureddin M, Choi G, Ayoub WS, Lagishetty V, Elashoff D, Goodman MT, Jacobs JP. Dietary Protein, Fiber and Coffee Are Associated with Small Intestine Microbiome Composition and Diversity in Patients with Liver Cirrhosis. Nutrients. 2020 May 13;12(5):1395. doi:10.3390/nu12051395. PMID:32414035.

Dong TS, Jacobs JP, Hussain SK. Microbial Profiles of Cirrhosis in the Human Small Intestine. Curr Gastroenterol Rep. 2019 Aug 23;21:50. doi:10.1007/s11894-019-0717-2.

Halec G, Waterboer T, Brenner N, Butt J, Hardy WD, D?Souza G, Wolinsky S, Macatangay BJ, Pawlita M, Detels R, Martínez-Maza O, Hussain SK. Serological Assessment of 18 Pathogens and Risk of AIDS-Associated Non-Hodgkin Lymphoma. J Acquir Immune Defic Syndr. 2019 Mar 1;80(3):e53-e63. doi:10.1097/QAI.0000000000001916. PMID:30531297.

Jacobs JP, Dong TS, Agopian V, Lagishetty V, Sundaram V, Noureddin M, Ayoub WS, Durazo F, Benhammou J, Enayati P, Elashoff D, Goodman MT, Pisegna J, Hussain S. Microbiome and bile acid profiles in duodenal aspirates from patients with liver cirrhosis: The Microbiome, Microbial Markers and Liver Disease Study. Hepatol Res. 2018 Dec;48(13):1108-1117. doi:10.1111/hepr.13207. Epub 2018 Jul 30. PMID:29923681.

Makgoeng SB, Bolanos RS, Jeon CY, Weiss RE, Arah OA, Breen EC, Martínez-Maza O, Hussain SK. Markers of Immune Activation and Inflammation, and Non-Hodgkin Lymphoma: A Meta-Analysis of Prospective Studies. JNCI Cancer Spectr. 2018 Dec;2(4):pky082. doi:10.1093/jncics/pky082. Epub 2019 Mar 5. PMID:30873511.

Epeldegui M, Magpantay L, Guo Y, Halec G, Cumberland WG, Yen PK, Macatangay B, Margolick JB, Rositch AF, Wolinsky S, Martinez-Maza O, Hussain SK. A prospective study of serum microbial translocation biomarkers and risk of AIDS-related non-Hodgkin lymphoma. AIDS. 2018 Apr 24;32(7):945-954. doi:10.1097/QAD.0000000000001771. PMID:29424776.

Fulcher JA, Hussain SK, Cook R, Li F, Tobin NH, Ragsdale A, Shoptaw S, Gorbach PM, Aldrovandi GM. Effects of Substance Use and Sex Practices on the Intestinal Microbiome During HIV-1 Infection. J Infect Dis. 2018 Oct 5;218(10):1560-1570. doi:10.1093/infdis/jiy349. PMID:29982500.

Peckham-Gregory EC, Thapa DR, Martinson J, Duggal P, Penugonda S, Bream JH, Chang PY, Dandekar S, Chang SC, Detels R, Martínez-Maza O, Zhang ZF, Hussain SK. MicroRNA-related polymorphisms and non-Hodgkin lymphoma susceptibility in the Multicenter AIDS Cohort Study. Cancer Epidemiol. 2016 Dec;45:47-57. doi:10.1016/j.canep.2016.09.007. Epub 2016 Oct 1. PMID:27701053.

Hussain SK, Makgoeng SB, Everly MJ, Goodman MT, Martínez-Maza O, Morton LM, Clarke CA, Lynch CF, Snyder J, Israni A, Kasiske BL, Engels EA. HLA and Risk of Diffuse Large B cell Lymphoma After Solid Organ Transplantation. Transplantation. 2016 Nov;100(11):2453-2460. doi:10.1097/TP.0000000000001025. PMID:26636741.