David Pleasure, M.D.

David Elliott Pleasure, M.D.







  • Director, Institute for Pediatric Regenerative Medicine
  • Distinguished Professor


To see if David Elliott Pleasure is accepting new patients, or for assistance finding a UC Davis doctor, please call 800-2-UCDAVIS (800-282-3284).

UC Davis Medical Center

2315 Stockton Blvd.
Sacramento, CA 95817
Driving Directions

Primary Phone:
800-2-UCDAVIS (800-282-3284)

Additional Phone Numbers

Physician Referrals: 800-4-UCDAVIS (800-482-3284)

Philosophy of Care

My goal is to deliver the most up-to-date and most appropriate care to my patients.

Clinical Interests

Dr. Pleasure's principal clinical interests include: Multiple sclerosis, Leukodystrophies, and Demyelinating Neuropathies.

Research/Academic Interests

My research centers on development and diseases of the nervous system, with a particular focus on disorders of glial cells.


Pediatric Neurology

Center/Program Affiliation

UC Davis Comprehensive Cancer Center
UC Davis Children's Hospital


M.D., Columbia University, College of Physicians and Surgeons, New York NY 1963

B.A., Yale University, New Haven CT 1959

Internship: University of Vermont, Burlington VT 1963-1964


Neurology, Neurological Institute-Columbia Univeristy, New York NY 1964-1966


Medical Neurology, National Institutes of Health, Bethesda MD 1966-1968

Board Certifications

American Board of Psychiatry and Neurology,

Professional Memberships

American Academy of Neurology - Fellow

American Association for the Advancement of Science

American Neurological Association - Honorary Member

Royal Society of Medicine

Honors and Awards

Javits Neuroscience Award, 1992

Associate Editor, JAMA Neurology, 2013

Associate Editor, Journal of Neuroscience, 2013

American Neurological Association - Honorary Memeber, 2016

AAAS - Fellow, 2016

Select Recent Publications

To view Dr. Pleasure's publications, please click here.

Wang YZ, Fan H, Ji Y, Reynolds K, Gu R, Gan Q, Yamagami T, Zhao T, Hamad S, Bizen N, Takebayashi H, Chen Y, Wu S, Pleasure D, Lam K, Zhou CJ. Olig2 regulates terminal differentiation and maturation of peripheral olfactory sensory neurons. Cell Mol Life Sci. 2020 Sep;77(18):3597-3609. doi:10.1007/s00018-019-03385-x. Epub 2019 Nov 22. PMID:31758234.

Pleasure D, Guo F, Chechneva O, Bannerman P, McDonough J, Burns T, Wang Y, Hull V. Pathophysiology and Treatment of Canavan Disease. Neurochem Res. 2020 Mar;45(3):561-565. doi:10.1007/s11064-018-2693-6. Epub 2018 Dec 8. PMID:30535831.

Hull V, Wang Y, Burns T, Zhang S, Sternbach S, McDonough J, Guo F, Pleasure D. Antisense Oligonucleotide Reverses Leukodystrophy in Canavan Disease Mice. Ann Neurol. 2020 Mar;87(3):480-485. doi:10.1002/ana.25674. Epub 2020 Jan 22. PMID:31925837.

Bannerman P, Guo F, Chechneva O, Burns T, Zhu X, Wang Y, Kim B, Singhal NK, McDonough JA, Pleasure D. Brain Nat8l Knockdown Suppresses Spongiform Leukodystrophy in an Aspartoacylase-Deficient Canavan Disease Mouse Model. Mol Ther. 2018 Mar 7;26(3):793-800. doi:10.1016/j.ymthe.2018.01.002. Epub 2018 Jan 10. PMID:29456021.

Yamagami T, Pleasure DE, Lam KS, Zhou CJ. Transient activation of Wnt/β-catenin signaling reporter in fibrotic scar formation after compression spinal cord injury in adult mice. Biochem Biophys Res Commun. 2018 Feb 19;496(4):1302-1307. doi:10.1016/j.bbrc.2018.02.004. Epub 2018 Feb 3. PMID:29410176.

Horiuchi M, Suzuki-Horiuchi Y, Akiyama T, Itoh A, Pleasure D, Carstens E, Itoh T. Differing intrinsic biological properties between forebrain and spinal oligodendroglial lineage cells. J Neurochem. 2017 Aug;142(3):378-391. doi:10.1111/jnc.14074. Epub 2017 Jun 9. PMID:28512742.

Pleasure D. New hearts for Friedreich patients. J Neurol Sci. 2017 Apr 15;375:474-475. doi:10.1016/j.jns.2017.01.035. Epub 2017 Jan 12. PMID:28131391.