The purpose of the UC Davis Clinical Research Guidebook is to provide a road map for navigation of the processes and procedures for conducting clinical research at UC Davis. The Clinical Research Guidebook also serves as a reference for investigators and site staff regarding the federal regulations governing clinical research in the United States. The Guidebook is not meant to be all inclusive; more help is available from the UC Davis Clinical and Translational Science Center, the UC Davis Institutional Review Board (IRB), UC Davis Health Compliance and Privacy Services and UC Davis Health Contracts – Clinical Trials Contracts. This Guidebook references materials from other sources with references cited whenever possible. Every effort is made to ensure the information is accurate as of the date of the publication.