Traumatic Injury Clinical Trial Evaluating Tranexamic Acid in Children

What is TXA?
Tranexamic Acid (TXA) is a medicine that helps stop bleeding. The purpose of this research study is to collect information on how well TXA works in severely injured children who are bleeding.
Who will be included?
Children younger than 18 years old with bleeding in inside their bodies or their brains will be included.
How will it affect me or my child?
If you or your child experiences a traumatic injury to the body or brain, he/she may receive TXA or placebo.
Where can I learn more about the study?
Visit our website at to learn more about the trial and ways to opt out.

TIC TOC Study Flyer (PDF)

Established Status Epilepticus Treatment Trial- Public Disclosure

A medical research study to learn how to treat patients with a type of prolonged seizures in the emergency department was recently performed in this community.

Before the study, doctors didn't know what medicine worked best. The study showed that three medicines commonly used to treat prolonged seizures all work similarly well, stopping seizures about half the time in both children and adults. The medicines were also similar in safety. These results give doctors more flexibility and confidence when treating patients with prolonged seizures.

The researchers thank the community for their support of this emergency research conducted with exception from consent. The study, called the Established Status Epilepticus Treatment Trial, or ESETT, was published in the November 28, 2019 issue of the New England Journal of
Medicine. The study was funded by the National Institutes of Health.

To learn more about the research and the results visit the ESETT website at:

ESETT End of Study (PDF)

ESETT New England Journal of Medicine (PDF)

Local ESETT Contact Information
UC Davis Medical Center
Phone: 916‐734‐8847 / E‐mail: