Anaclet Research | Neurological Surgery Research

Christelle Anaclet received her Ph.D. from Claude Bernard University, Lyon, France, under the supervision of Dr. Jian-Sheng Lin. She completed her postdoctoral training at Beth Israel Deaconess Medical Center and Harvard Medical School, initially under the guidance of Dr. Jun Lu and later under Dr. Patrick Fuller. Anaclet's research is centered on the neurocircuitry that regulates sleep-wake cycles. Her work has led to the discovery of the sleep-promoting parafacial zone, which contains GABAergic neurons responsible for triggering, sustaining, and enhancing slow-wave sleep (SWS), the deepest stage of sleep. Through her studies, she developed a mouse model that allows for the on-demand triggering, sustaining, and enhancement of SWS. With this unique mouse model, she investigates the beneficial role of sleep in physiology and various diseases, with a particular focus on cognition in the context of aging and Alzheimer’s disease.