Mary Jacena S. Leigh, M.D.

Associate Physician Diplomate

Volunteer Assistant Clinical Professor

To see if Mary Jacena S. Leigh is accepting new patients, or for assistance finding a UC Davis doctor, please call 800-2-UCDAVIS (800-282-3284).



Pediatric Child Development & Behavior



Locations and Contact

2825 50th St.
Sacramento, CA 95817

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Additional Numbers



Clinic Fax


Physician Referrals

800-4-UCDAVIS (800-482-3284)

Philosophy of Care

Dr. Leigh works with children and their caregivers to identify developmental delays and/or neurodevelopmental disorders and to provide best practice treatments and recommendations. She strives to provide patient-centered care incorporating a child's strengths and challenges in the context of the family, school and community environment, to help optimize each child's potential. 

Clinical Interests

Dr. Leigh is developmental-behavioral pediatrician interested in general child development, both typical and atypical, and in neurodevelopmental disorders, including autism spectrum disorder and attention deficit hyperactivity disorder. She has particular interest and experience providing developmental evaluations for young children who are at high risk for developmental delays and neurodevelopmental disorders. 

Research/Academic Interests

Dr. Leigh is involved in research aimed at developing targeted treatments for genetic and neurodevelopmental disorders. She is currently a clinician in clinical trials and research studies for individuals with fragile X syndrome, Down syndrome and autism spectrum disorder.


Child Development and Behavior

Center/Program Affiliation

UC Davis MIND Institute
UC Davis Children's Hospital

Undergraduate School

B.A., UC Berkeley, Berkeley CA 2011

Medical School

M.D., Geffen School of Medicine-UCLA, Los Angeles CA 2006


Pediatrics, UC Davis Medical Center, Sacramento CA 2006-2007


Pediatrics, UC Davis Medical Center, Sacramento CA 2007-2009


Developmental and Behavioral Pediatrics, UC Davis MIND Institute, Sacramento CA 2009-2012

Conquer Fragile X Young Investigator Award, National Fragile X Foundation, 2012

Annual Meeting Travel Award, Pediatric Academic Society, 2012

Abbott Nutrition David W. Smith Pediatric Trainee Research Award, Western Society of Pediatric Research, 2012

Jeanne Spurlock Clinical Fellowship, American Academy of Child and Adolescent, 2003

I.L. Chaikoff Memorial Award for Outstanding Achievement and Excellence in Molecular & Cell Biology/Cell & Developmental Biology, UC Berkeley, 2001

Leigh MJ, Hagerman RJ. Fragile X - Clinical and Neurobiology. Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease, Sixth Edition Vols 1 and 2, eds. R Rosenberg & J Pascual, Oxford: Elsevier. 2020.

Schneider A, Leigh MJ, Adams P, Nanakul R, Chechi T, Olichney J, Hagerman RJ, Hessl D. Electrocortical Changes Associated with Minocycline Treatment in Fragile X Syndrome. J Psychopharmacol. 2013 Oct;27(10):956-63. Epub 2013 Aug 27.

Dziembowska M, Pretto DI, Janusz A, Kaczmarek L, Leigh MJ, Gabriel N, Durbin-Johnson B, Hagerman RJ, Tassone F. High MMP-9 activity levels in fragile X syndrome are lowered by minocycline. Am J Med Genet A. 2013 Aug;161A(8):1897-903. Epub 2013 Jul 3.

Leigh MJ, Nguyen DV, Mu Y, Winarni TI, Schneider A, Chechi T, Polussa J, Doucet P, Tassone F, Rivera SM, Hessl D, Hagerman RJ. A randomized double-blind, placebo-controlled trial of minocycline in children and adolescents with fragile x syndrome. J Dev Behav Pediatr. 2013 Apr;34(3):147-55. 

Gianoukakis AG, Leigh MJ, Richards P, Christenson PD, Hakimian A, Fu P, Niihara Y, Smith TJ. Characterization of the anemia associated with Graves' disease. Clinical Endocrinology. 2009 May;70(5):781-7.

Machen TE, Leigh MJ, Taylor C, Kimura T, Asano S, Moore HP.  pH of TGN and recycling endosomes of H+/K+-ATPase-transfected HEK-293 cells: implications for pH regulation in the secretory pathway. Am J of Physiology- Cell Physiology. 2003 Jul;285 (1):C205-14. 

Leigh MJ, Partington L, Weeber E. Angelman Syndrome. Treatment of Neurodevelopmental Disorders-Targeting Neurobiological Mechanisms, eds. B Moghaddam, R Hagerman, and R Hendren, Oxford: Elsevier. 2014.

Leigh MJ, Hagerman RJ, Hessl, DR. Fragile X. Clinical Manual of Neurodevelopmental Disorders, eds. S. Rogers and R. Hansen, Arlington: American Psychiatric Publishing. 2012.

Hendrickson DJ, Knisely AS, Coulter K, Telander DG, Quan R, Ruebner BH, Leigh MJ. An inborn error of bile salt transport with features mimicking abusive head trauma. Child Abuse & Neglect. 2010 Jul;34(7):472-6. doi:10.1016/j.chiabu.2009.11.008. Epub 2010 Jun 2.