Eleonora Grandi, Ph.D.
Chair, Biophysics Graduate Group
Professor, Department of Pharmacology
Specialties
Cardiac Electrophysiology
Mathematical Modeling and Simulation
Department
Locations and Contact
Research/Academic Interests
Dr. Grandi's research aims at understanding the molecular, cellular, and tissue-level mechanisms of complex cardiovascular diseases, such as heart failure, atrial fibrillation, and hypertension. This is achieved by developing biophysically detailed, mechanistic computational models, based on bioengineering principles. These frameworks serve as platforms for accurate prediction of disease mechanism, and testing of pharmacological interventions to guide therapeutic strategies.
Division
Pharmacology
Undergraduate School
B.S., Electronics Engineering, University of Bologna, Bologna, Italy 2003
Other School
Ph.D., Bioengineering, University of Bologna, Bologna, Italy 2007
Other School
M.S., Electronics Engineering, University of Bologna, Bologna, Italy 2003
Graduate Program Advising and Mentoring Award, 2022
Graduate Studies Distinguished Graduate and Postdoctoral Mentoring Award, 2021
Chancellor’s fellow, UC Davis, 2019
Fellow of the Heart Rhythm Society, 2019
Dean’s fellow in Precision Medicine, UC Davis School of Medicine, 2018
To view Grandi's publications, please click here.
Zhang X, Ni H, Morotti S, Smith CER, Sato D, Louch WE, Edwards AG, Grandi E. Mechanisms of spontaneous Ca2+ release-mediated arrhythmia in a novel 3D human atrial myocyte model: I. Transverse-axial tubule variation. J Physiol. 2022 Sep 12. doi:10.1113/JP283363. Epub ahead of print. PMID:36094888.
Zhang X, Smith CER, Morotti S, Edwards AG, Sato D, Louch WE, Ni H, Grandi E. Mechanisms of spontaneous Ca2+ release-mediated arrhythmia in a novel 3D human atrial myocyte model: II Ca2+ -handling protein variation. J Physiol. 2022 Sep 16. doi:10.1113/JP283602. Epub ahead of print. PMID:36114707.
Morotti S, Liu C, Hegyi B, Ni H, Fogli Iseppe A, Wang L, Pritoni M, Ripplinger CM, Bers DM, Edwards AG, Grandi E. Quantitative cross-species translators of cardiac myocyte electrophysiology: Model training, experimental validation, and applications. Sci Adv. 2021 Nov 19;7(47):eabg0927. doi:10.1126/sciadv.abg0927. Epub 2021 Nov 17. PMID:34788089.
Fogli Iseppe A, Ni H, Zhu S, Zhang X, Coppini R, Yang PC, Srivatsa U, Clancy CE, Edwards AG, Morotti S, Grandi E. Sex-Specific Classification of Drug-Induced Torsade de Pointes Susceptibility Using Cardiac Simulations and Machine Learning. Clin Pharmacol Ther. 2021 Mar 26. doi:10.1002/cpt.2240. Online ahead of print. PMID:33772748.
Ni H, Fogli Iseppe A, Giles WR, Narayan SM, Zhang H, Edwards AG, Morotti S, Grandi E. Populations of in silico myocytes and tissues reveal synergy of multiatrial-predominant K+ -current block in atrial fibrillation. Br J Pharmacol. 2020 Oct;177(19):4497-4515. doi:10.1111/bph.15198. Epub 2020 Aug 9. PMID:32667679.
Kernik DC, Morotti S, Wu H, Garg P, Duff HJ, Kurokawa J, Jalife J, Wu JC, Grandi E, Clancy CE. A computational model of induced pluripotent stem-cell derived cardiomyocytes incorporating experimental variability from multiple data sources. J Physiol. 2019 Sep;597(17):4533-4564. doi:10.1113/JP277724. Epub 2019 Jul 27. PMID:31278749.
Morotti S, McCulloch AD, Bers DM, Edwards AG, Grandi E. Atrial-selective targeting of arrhythmogenic phase-3 early afterdepolarizations in human myocytes. J Mol Cell Cardiol. 2016 Jul;96:63-71. doi:10.1016/j.yjmcc.2015.07.030. Epub 2015 Aug 1. PMID:26241847.
Grandi E, Pandit SV, Voigt N, Workman AJ, Dobrev D, Jalife J, Bers DM. Human atrial action potential and Ca2+ model: sinus rhythm and chronic atrial fibrillation. Circ Res. 2011 Oct 14;109(9):1055-66. doi:10.1161/CIRCRESAHA.111.253955. Epub 2011 Sep 15. PMID:21921263.
Grandi E, Pasqualini FS, Bers DM. A novel computational model of the human ventricular action potential and Ca transient. J Mol Cell Cardiol. 2010 Jan;48(1):112-21. doi:10.1016/j.yjmcc.2009.09.019. Epub 2009 Oct 14. PMID:19835882.