Eleonora Grandi, Ph.D.
Associate Professor
Locations and Contact
Additional Numbers
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Research/Academic Interests
Dr. Grandi's research aims at understanding the molecular, cellular, and tissue-level mechanisms of complex cardiovascular diseases, such as heart failure, atrial fibrillation, and hypertension. This is achieved by developing biophysically detailed, mechanistic computational models, based on bioengineering principles. These frameworks serve as platforms for accurate prediction of disease mechanism, and testing of pharmacological interventions to guide therapeutic strategies.
Division
Pharmacology
Undergraduate School
B.S./M.S., University of Bologna, Bologna, Italy 2003
Other School
Ph.D., Bioengineering, University of Bologna, Bologna, Italy 2007
Chancellor�s fellow, UC Davis, 2019
Journal of Physiology Editorial Board Fellowship, 2019
Fellow of the Heart Rhythm Society, 2019
Deans' Team Award for Excellence in Research (SPARC Team: Clancy, Grandi, Santana, Ripplinger, Vorobyov, Lewis, McCulloch), 2018
Dean�s fellow in Precision Medicine, UC Davis School of Medicine, 2018
Dean�s Award for Excellence in Mentoring at Early or Mid-Career Level, School of Medicine, UC Davis, 2015
To view Grandi's publications, please click here.
Fogli Iseppe A, Ni H, Zhu S, Zhang X, Coppini R, Yang PC, Srivatsa U, Clancy CE, Edwards AG, Morotti S, Grandi E. Sex-Specific Classification of Drug-Induced Torsade de Pointes Susceptibility Using Cardiac Simulations and Machine Learning. Clin Pharmacol Ther. 2021 Mar 26. doi:10.1002/cpt.2240. Online ahead of print. PMID:33772748.
McCulloch AD, Grandi E, Saucerman JJ. Computational models of cardiovascular regulatory mechanisms. J Mol Cell Cardiol. 2021 Feb 26;155:111. doi:10.1016/j.yjmcc.2021.01.009. Online ahead of print. PMID:33647311.
Ni H, Fogli Iseppe A, Giles WR, Narayan SM, Zhang H, Edwards AG, Morotti S, Grandi E. Populations of in silico myocytes and tissues reveal synergy of multiatrial-predominant K+ -current block in atrial fibrillation. Br J Pharmacol. 2020 Oct;177(19):4497-4515. doi:10.1111/bph.15198. Epub 2020 Aug 9. PMID:32667679.
Zaza A, Grandi E. Mechanisms of Cav3-associated arrhythmia: Protein or microdomain dysfunction? Int J Cardiol. 2020 Dec 1;320:97-99. doi:10.1016/j.ijcard.2020.06.051. Epub 2020 Jul 4. PMID:32634502.
Xu B, Li M, Wang Y, Zhao M, Morotti S, Shi Q, Wang Q, Barbagallo F, Teoh JP, Reddy GR, Bayne EF, Liu Y, Shen A, Puglisi JL, Ge Y, Li J, Grandi E, Nieves-Cintron M, Xiang YK. GRK5 Controls SAP97-Dependent Cardiotoxic β1 Adrenergic Receptor-CaMKII Signaling in Heart Failure. Circ Res. 2020 Aug 28;127(6):796-810. doi:10.1161/CIRCRESAHA.119.316319. Epub 2020 Jun 8. PMID:32507058.
Tazmini K, Frisk M, Lewalle A, Laasmaa M, Morotti S, Lipsett DB, Manfra O, Skogestad J, Aronsen JM, Sejersted OM, Sjaastad I, Edwards AG, Grandi E, Niederer SA, Øie E, Louch WE. Hypokalemia Promotes Arrhythmia by Distinct Mechanisms in Atrial and Ventricular Myocytes. Circ Res. 2020 Mar 27;126(7):889-906. doi:10.1161/CIRCRESAHA.119.315641. Epub 2020 Feb 19. PMID:32070187.
Grandi E, Dobrev D. Atrial fibrillation in a dish: insights into atrial arrhythmogenesis from induced pluripotent stem cell-derived cardiomyocytes. Cardiovasc Res. 2020 May 1;116(6):1089-1091. doi:10.1093/cvr/cvz342. PMID:31860074.
Li Z, Mirams GR, Yoshinaga T, Ridder BJ, Han X, Chen JE, Stockbridge NL, Wisialowski TA, Damiano B, Severi S, Morissette P, Kowey PR, Holbrook M, Smith G, Rasmusson RL, Liu M, Song Z, Qu Z, Leishman DJ, Steidl-Nichols J, Rodriguez B, Bueno-Orovio A, Zhou X, Passini E, Edwards AG, Morotti S, Ni H, Grandi E, Clancy CE, Vandenberg J, Hill A, Nakamura M, Singer T, Polonchuk L, Greiter-Wilke A, Wang K, Nave S, Fullerton A, Sobie EA, Paci M, Musuamba Tshinanu F, Strauss DG. General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy. Clin Pharmacol Ther. 2020 Jan;107(1):102-111. doi:10.1002/cpt.1647. Epub 2019 Nov 10. PMID:31709525.
Zhang J, Grandi E, Fu H, Saravanan T, Bothof L, Tepper PG, Thunnissen AWH, Poelarends GJ. Engineered C-N Lyase: Enantioselective Synthesis of Chiral Synthons for Artificial Dipeptide Sweeteners. Angew Chem Int Ed Engl. 2020 Jan 2;59(1):429-435. doi:10.1002/anie.201910704. Epub 2019 Nov 19. PMID:31625664.